Multiple Littoral Cell Angioma of the Spleen: A Case Report and Review of the Literature

Qu, Zhibo; Liu, Lianxin; Wu, Linfeng; Zhao, Song; Jiang, Hongchi

doi:10.1159/000101010

Cited by 14 publications

(11 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Immunohistocytologically, the tumor cells are positive for vimentin, CD31 CD68, CD21, CD8 and FVIIIrAg, while the Ki-67 index is likely to be very low (~1%), as previously described in the literature [1,3,15,20,21].…”

mentioning

confidence: 57%

See 1 more Smart Citation

Is littoral cell angioma of the spleen as rare as previously believed in the pediatric population?

Matuszczak¹,

Reszeć²,

Dębek³

et al. 2012

Folia Histochem Cytobiol.

View full text Add to dashboard Cite

Littoral cell angioma (LCA) is a rare primary splenic vascular tumor, originating from the littoral cells lining the red pulp sinuses of the spleen. There are only a handful of case reports of LCA in children to be found in the literature. We performed a retrospective analysis of the medical charts of pediatric patients with splenic lesions who were treated between 2005 and 2010 in the Pediatric Surgery Department of the Medical University of Bialystok. Surprisingly, LCA accounted for 37.5% of the splenic lesions found in our series. The majority of LCA tumors are benign, but given their malignant potential, splenectomy and long-term follow-up should be the gold standard for their management. We strongly support the use of further cross-sectional studies to properly elucidate the prevalence of littoral cell angioma of the spleen in the pediatric population. (Folia Histochemica et Cytobiologica 2012, Vol. 50, No. 3, 480-485)

show abstract

mentioning

confidence: 57%

“…Atypical cells are absent, and mitotic activity is usually very low. High-field magnification typically reveals tall and plump sinuslining cells with little mitosis, and no cytologic atypia to suggest malignancy [11,[16][17][18][19][20].…”

mentioning

confidence: 99%

Is littoral cell angioma of the spleen as rare as previously believed in the pediatric population?

Matuszczak¹,

Reszeć²,

Dębek³

et al. 2012

Folia Histochem Cytobiol.

View full text Add to dashboard Cite

show abstract

“…Some cases of hyperechoic littoral cell angioma have been misdiagnosed as hemangioma on sonography. 3,20,21 In our study, 2 of the 3 hypervascular lesions were full of color flow signals when the scale was 0.077 m/s. Intralesional arterial flow signals could be clearly displayed when the scale was high enough (≥0.254 m/s).…”

Section: Discussionmentioning

confidence: 48%

“…Görg et al 16 reported 2 cases and reviewed 5 additional cases of littoral cell angioma in the literature; all cases were hyperechoic, and 6 (86%) were multiple lesions. However, in 20 cases of littoral cell angioma reported in the English literature, [3][4][5][6][7][8][9][10][11][12][17][18][19][20][21][22][23][24] 10 cases (50%) were hyperechoic, 10 (50%) were hypoechoic or isoechoic, and 12 (60%) were multiple lesions. In our study, 2 patients (29%) had multiple hyperechoic lesions, and 5 (71%) had solitary hypoechoic lesions.…”

Section: Discussionmentioning

confidence: 99%

Littoral Cell Angioma of the Spleen

Yunhua

Liu

Wang

et al. 2013

Journal of Ultrasound in Medicine

View full text Add to dashboard Cite

Objectives The purpose of this study was to evaluate the sonographic and pathologic features of littoral cell angioma of the spleen in 7 patients. Methods The sonographic appearance in 7 cases of littoral cell angioma confirmed by surgical pathologic examination was retrospectively reviewed. All underwent color Doppler imaging. Two underwent contrast‐enhanced sonography. The sonographic appearance was compared with pathologic findings. Results Splenic lesions were solitary in 5 cases and multiple in 2 cases. The masses ranged from 10 to 64 mm in maximum diameter. Five hypoechoic and 2 hyperechoic lesions on grayscale sonography corresponded to few and multiple blood‐filled spaces on pathologic examination, respectively. Four hypovascular lesions, 1 hypervascular lesion, and the other 2 hypervascular lesions full of color flow signals on color Doppler imaging corresponded to few, several, and multiple arteries on pathologic examination. On contrast‐enhanced sonography, 1 hypervascular lesion full of color flow signals showed homogeneous hyperenhancement for 8 minutes during the arterial and parenchymal phases. One hypovascular lesion showed inhomogeneous isoenhancement transiently during the arterial phase and became hypoechoic later. Conclusions Littoral cell angioma is a primary vascular splenic neoplasm with variable features on grayscale sonography and color Doppler imaging as well as contrast‐enhanced sonography. The sonographic appearance of littoral cell angioma mainly depends on the type and number of tumor vessels.

show abstract

“…Desde entonces, se han notificado alrededor de 80 casos adicionales. 2,3 La presentación clínica del ACL suele variar desde ser completamente asintomática y descubierta incidentalmente, hasta presentar una constelación de signos y síntomas como distensión abdominal, síntomas constitucionales complejos, esplenomegalia e hiperesplenismo. Aunque la tomografía computarizada (TC) y el ultrasonido (US) característicos de esta neoplasia han sido bien descritos, hay una falta de especificidad en la diferenciación del tumor de otros tumores vasculares primarios esplénicos, entre ellos, hemangiomas y angiosarcomas.…”

Section: Introductionunclassified

Rotura Esplénica Espontánea Secundaria A Angioma de Células Litorales

Pérez-Alonso¹,

Olmo-Rivas²,

Machado-Romero³

et al. 2017

Panamerican Journal of Trauma, Critical Care &Amp; Emergency Surgery

View full text Add to dashboard Cite

Introducción: Presentamos un angioma de células litorales (LCA, por sus siglas en inglés), una rara neoplasia vascular esplé-nica que surge de las células que recubren los senos de la pulpa roja. Se considera una lesión benigna y de hallazgo accidental.Presentación del caso: varón de 50 años acude con una rotura esplénica espontánea. Al principio del proceso, el paciente presentaba fatiga, debilidad y distensión abdominal. Se realizó una ecografía abdominal donde se observaron hemangiomas múltiples en el bazo. La tomografía computarizada reveló esplenomegalia con múltiples lesiones redondas e hiperdensas. El paciente fue sometido posteriormente a cirugía y se realizó una esplenectomía. Los estudios histológicos e immunohistoquímicos confirmaron el diagnóstico de LCA.Discusión: Un LCA es un tumor esplénico poco frecuente diagnosticado en pacientes que pueden o no presentar molestias abdominales. Suele presentarse con síntomas de hiperesplenismo, y debe realizarse el diagnóstico diferencial entre los tumores vasculares esplénicos divididos entre neoplasias benignas, indeterminadas, o neoplasias malignas.Conclusión: Debido a la asociación de LCA a neoplasias de colon, riñón, páncreas, pulmón, ovario, leiomiosarcoma, melanoma y linfoma, se debe descartar el neoplasma visceral en estos pacientes. Pocos informes sobre este tipo de tumor han sido publicados, y de manera inconsistente. Presentamos pues un nuevo caso y revisión de la literatura actual.Palabras Claves: Angioma de células litorales, Cirugía, Inmunohistoquímica e histología, Neoplasia vascular.How to cite this article: Pérez-Alonso AJ, Caballero-Marcos L, del Olmo-Rivas C, Machado-Romero I, Petrone P. Rotura Esplénica Espontánea Secundaria A Angioma de Células Litorales. Panam J Trauma Crit Care Emerg Surg 2017;6(2):131-133. Source of support: Nil Conflict of interest: None ABSTRACTIntroduction: We present a littoral cell angioma (LCA), a rare splenic vascular neoplasm that arises from the cells lining the red pulp sinuses. It is deemed to be a benign and incidental lesion. Case report:A 50-year-old male presented with a spontaneous splenic rupture. At the beginning of this process, the patient had abdominal distension, weakness and fatigue. An abdominal ultrasound was performed and multiple hemangiomas were observed in the spleen. Computed tomography scans revealed splenomegaly with multiple round and hyperdense lesions. The patient subsequently underwent surgery and a splenectomy was performed. Postoperative histological and immunohistochemical studies confirmed the diagnosis of LCA.Discussion: LCA is an uncommon splenic tumor diagnosed in patients presenting with or without abdominal discomfort. It can present with symptoms of hyperesplenism, and the differential diagnosis of splenic vascular tumors can be divided into benigns, indeterminate, or malignant neoplasms. Conclusion:Due to its association with neoplasms of the colon, kidney, pancreas, lung, ovary, leiomyosarcoma, melanoma and lymphoma, becomes mandatory to rule out a visceral neoplasm from the...

show abstract

Multiple Littoral Cell Angioma of the Spleen: A Case Report and Review of the Literature

Cited by 14 publications

References 17 publications

Is littoral cell angioma of the spleen as rare as previously believed in the pediatric population?

Is littoral cell angioma of the spleen as rare as previously believed in the pediatric population?

Littoral Cell Angioma of the Spleen

Rotura Esplénica Espontánea Secundaria A Angioma de Células Litorales

Contact Info

Product

Resources

About