Multiple Measures of Mineral Metabolism Were Associated With Renal Function in Chinese Centenarians: A Cross-Sectional Study

Fu, Shihui; Yu, Haotian; Li, Yulong; Lv, Faqin; Deng, Juelin; Fu, Zhang; Luan, Fuxin; Zhao, Yali; Yao, Yao

doi:10.3389/fmed.2020.00120

Cited by 7 publications

(5 citation statements)

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“…Subcutaneous and visceral concentrations of osteocalcin have been identified to be associated with body mass or abdominal obesity [ 45 ]. However, little is known about the relationships between bone turnover and abdominal obesity in the oldest individuals [ 46 ]. Meanwhile, although substantial relationships between bone turnover and nutritional status have been recognized in postmenopausal women, there has been a scarcity of data regarding nutrition-associated changes in bone turnover in the oldest population.…”

Section: Discussionmentioning

confidence: 99%

Centenarian longevity had inverse relationships with nutritional status and abdominal obesity and positive relationships with sex hormones and bone turnover in the oldest females

Ping

et al. 2021

J Transl Med

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Objective The number of older people is estimated to increase from 524 million in 2010 to 1.5 billion in 2050. The factors and models of human longevity and successful aging are questions that have intrigued individuals for thousands of years. For the first time, the current study was designed to investigate the relationships between sex hormones, bone turnover, abdominal obesity, nutritional status and centenarian longevity in the oldest females. Methods The China Hainan Centenarian Cohort Study was performed in 18 cities and counties of Hainan Province using standard methodology in 500 centenarian females and 237 oldest females aged between 80 and 99 years. Results Centenarians were inversely associated with the geriatric nutritional risk index [Exp(B) (95% CI): 0.901 (0.883–0.919)] and abdominal obesity [Exp(B) (95% CI): 0.719 (0.520–0.996)] and positively associated with prolactin [Exp(B) (95% CI): 1.073 (1.044–1.103)], progesterone [Exp(B) (95% CI): 44.182 (22.036–88.584)], estradiol [Exp(B) (95% CI): 1.094 (1.071–1.119)], osteocalcin [Exp(B) (95% CI): 1.041 (1.028–1.054)], β-crossLaps [Exp(B) (95% CI): 63.141 (24.482–162.848)] and parathyroid [Exp(B) (95% CI): 1.022 (1.013–1.031)] hormone levels (P < 0.05 for all). The geriatric nutritional risk index and abdominal obesity were inversely associated with luteinizing hormone [β coefficient (95% CI): − 0.001 (− 0.002 to 0.001)]; Exp(B) (95% CI): 0.985 (0.974–0.996)], follicle-stimulating hormone [β coefficient (95% CI): 0.000 (− 0.001 to 0.000)]; Exp(B) (95% CI): 0.990 (0.985–0.996)], osteocalcin [β coefficient (95% CI): − 0.001 (− 0.001 to 0.000)]; Exp(B) (95% CI): 0.987(0.977–0.997)] and β-crossLaps [β coefficient (95% CI): − 0.100 (− 0.130 to 0.071)]; Exp(B) (95% CI): 0.338 (0.166–0.689)] levels (P < 0.05 for all). Conclusions Centenarian longevity had inverse relationships with nutritional status and abdominal obesity and positive relationships with sex hormones and bone turnover. Nutritional status and abdominal obesity had inverse relationships with sex hormones and bone turnover. Increased sex hormones and bone turnover may be representative of centenarian longevity. Optimizing nutritional status and avoiding abdominal obesity may increase sex hormones and bone turnover and promote centenarian longevity and successful aging.

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Section: Discussionmentioning

confidence: 99%

Centenarian longevity had inverse relationships with nutritional status and abdominal obesity and positive relationships with sex hormones and bone turnover in the oldest females

Ping

et al. 2021

J Transl Med

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“…Using the list of oldest-old and centenarian adults provided by the Department of Civil Affairs of Hainan Province, China, a household survey was conducted on all centenarians (100 years or older) and oldest-old adults (80–99 years) residing in 16 cities and counties of Hainan province from June 2014 to June 2016 ( Figure 1 ). 9 , 10 The survey sample of 1863 cases included 966 centenarians and 897 oldest-old adults. The inclusion criteria were: 1) aged ≥ 80 years; 2) residing in Hainan province.…”

Section: Methodsmentioning

confidence: 99%

Age Related Cognitive Function Was Positively Associated with Diastolic Pressure and Negatively Associated with Antibody Expression in Chinese Oldest-Old and Centenarian Adults

Feng¹,

Wu²,

Ping³

et al. 2022

JIR

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Purpose Age related cognitive function (ARCF) is of increasing concern in an aging population. Few studies have examined the relationships between ARCF and antibody expression or blood pressure, particularly in older populations. Large sample sizes are needed to elucidate these relationships to inform better strategies for identification and prevention of cognitive decline. The present study was designed to investigate these relationships in Chinese oldest-old and centenarian adults. Patients and Methods A household survey was performed that included 436 centenarians and 520 oldest-old adults (80–99 years) residing in 16 cities and counties of Hainan province, China. ARCF was assessed using the mini-mental state examination. Results The median age of participants in this study was 92 years, with a range of 80 to 116 years. Females accounted for 68.5% (655) of the participant pool. Multivariate linear regression analysis showed that age [Exp(B): −0.220, 95% confidence interval (CI): −0.270–-0.169], female gender [Exp(B): −3.459, 95% CI:-4.458–-2.460], Han ethnicity [Exp(B): −1.732, 95% CI: −2.693–-0.772], serum creatinine [Exp(B): −0.019, 95% CI: −0.037–-0.001], immunoglobulin light chain KAP [Exp(B): −0.008, 95% CI: −0.015–0.000], and anti-ribonucleoprotein antibody [Exp(B): −6.393, 95% CI: −10.898–-1.887] were negatively associated with ARCF (P < 0.05). Coronary artery disease [Exp(B): 1.957, 95% CI: 0.170–3.744] and diastolic pressure [Exp(B): 0.041, 95% CI: 0.002–0.079] were positively associated with ARCF (P < 0.05). Conclusion ARCF was positively associated with diastolic pressure and negatively associated with antibody expression in Chinese oldest-old and centenarian adults.

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“…Hainan Province is an area with high prevalence of longevity; in fact, it has the highest population density of oldest-old females in China. Oldest-old females may represent a prototype of human longevity and should be considered the best representative [ 16 ]. The China Hainan Oldest-old Cohort Study (CHOCS) provides a considerable population-based sample of oldest-old females [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Positive associations between sex hormones, bone metabolism and cognitive impairment in Chinese oldest-old females

et al. 2023

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Purpose With a rapid increase in older adults, progressive impairment in cognitive function has become an increasing concern owing to high social and economic burdens. The current study was designed to investigate the associations of sex hormones and bone metabolism with cognitive impairment (CI) in Chinese oldest-old females. Methods There were 396 oldest-old females from the China Hainan Oldest-old Cohort Study (CHOCS). Following standardized procedures, Mini Mental State Examination was effectively completed, and sex hormones and bone metabolism were assessed in these females. Results The median age of all females was 101 years (range: from 80 to 116). There were 340 females (86%) with CI. Participants with CI had significantly higher levels of age, progesterone, prolactin and estradiol than those without CI (P < 0.05 for all). Total type I collagen N-terminal elongation peptide [hazard ratio (HR): 1.018, 95%CI: 1.001–1.035] and prolactin (HR: 1.065, 95%CI: 1.005–1.129) levels were positively and significantly associated with CI (P < 0.05 for all). Conclusions Prolactin and total type I collagen N-terminal elongation peptide had positive associations with CI in Chinese oldest-old females. Thus, a balance in sex hormones and bone metabolism may have significant effects on cognitive function during the aging process.

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Multiple Measures of Mineral Metabolism Were Associated With Renal Function in Chinese Centenarians: A Cross-Sectional Study

Cited by 7 publications

References 30 publications

Centenarian longevity had inverse relationships with nutritional status and abdominal obesity and positive relationships with sex hormones and bone turnover in the oldest females

Centenarian longevity had inverse relationships with nutritional status and abdominal obesity and positive relationships with sex hormones and bone turnover in the oldest females

Age Related Cognitive Function Was Positively Associated with Diastolic Pressure and Negatively Associated with Antibody Expression in Chinese Oldest-Old and Centenarian Adults

Positive associations between sex hormones, bone metabolism and cognitive impairment in Chinese oldest-old females

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