Multiple mechanisms of curcumin targeting spinal cord injury

Gu, Guangjin; Ren, Jie; Zhu, Bin; Shi, Zhongju; Feng, Shiqing; Wei, Zhijian

doi:10.1016/j.biopha.2023.114224

Cited by 15 publications

(3 citation statements)

References 176 publications

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“…Traditional Chinese medicine (TCM) is a promising supplementary treatment method that has attracted cosiderable attention in recent years. Studies have demonstrated that herbal active extracts, metabolites, and traditional botanical formulas are effective and can play an important role in the prevention and treatment of SCI, especially in reducing pyroptosis [125]. Hu et al [120] showed that Taxifolin significantly reduced oxidative stress mediated by microglial activation, and inhibited the post-SCI expression of pyroptosis-associated proteins (NLRP3, Caspase-1, GSDMD, and ASC) and inflammatory cytokines (IL-1β and IL-18).…”

Section: Traditional Chinese Medicinementioning

confidence: 99%

Pyroptosis in Spinal Cord Injury: Implications for Pathogenesis and Therapeutic Approaches

Gu,

Yu,

Zou

et al. 2024

Front. Biosci. (Landmark Ed)

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Traumatic spinal cord injury (SCI) is a serious disease of the central nervous system. Aside from the limited intrinsic regenerative capacity of neurons, complex microenvironmental disturbances can also lead to further cellular damage and growth inhibition. Programmed cell death regulated by pyroptosis has an important role in the pathogenesis of SCI. While there has been a wealth of new knowledge regarding cellular pyroptosis, a detailed understanding of its role in SCI and possible therapeutic strategies is still lacking. This review summarizes current advances in the regulatory role of pyroptosis-regulated cell death and inflammasome components in the inhibitory microenvironment following SCI, as well as recent therapeutic advances.

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Section: Traditional Chinese Medicinementioning

confidence: 99%

Pyroptosis in Spinal Cord Injury: Implications for Pathogenesis and Therapeutic Approaches

Gu,

Yu,

Zou

et al. 2024

Front. Biosci. (Landmark Ed)

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“…Overall, the engineered modification led to a significant upregulation of CCR2 expression, confirming the successful establishment of RAW 264.7-CCR2 cells. Curcumin (Cur), chosen as the model drug for our study, is known for its potential to enhance neuroprotective efficacy in SCI by suppressing neuroinflammation and oxidative stress, [40] making it a promising candidate for combined therapy. [19,41,42] To address the challenge of low water solubility and bioavailability of Cur, we prepared PLGA nanoparticles (PLGA/NPs) loaded with Cur (PLGA/Cur) using nanoprecipitation.…”

Section: Fabrication and Characterization Of Ccr2-mm@plga/curmentioning

confidence: 99%

Engineered Macrophage Membrane‐Coated Nanoparticles with Enhanced CCR2 Expression Promote Spinal Cord Injury Repair by Suppressing Neuroinflammation and Neuronal death

Gu,

Geng,

et al. 2023

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Spinal cord injury (SCI) is a severe neurological disorder characterized by significant disability and limited treatment options. Mitigating the secondary inflammatory response following the initial injury is the primary focus of current research in the treatment of SCI. CCL2 (C─C motif chemokine ligand 2) serves as the primary regulator responsible for inflammatory chemotaxis of the majority of peripheral immune cells, blocking the CCL2‐CCR2 (C─C chemokine receptor type 2) axis has shown considerable therapeutic potential for inflammatory diseases, including SCI. In this study, it presents a multifunctional biomimetic nanoplatform (CCR2‐MM@PLGA/Cur) specifically designed to target the CCL2‐CCR2 axis, which consisted of an engineered macrophage membrane (MM) coating with enhanced CCR2 expression and a PLGA (poly (lactic‐co‐glycolic acid)) nanoparticle that encapsulated therapeutic drugs. CCR2 overexpression on MM not only enhanced drug‐targeted delivery to the injury site, but also attenuated macrophage infiltration, microglia pro‐inflammatory polarization, and neuronal apoptosis by trapping CCL2. Consequently, it facilitated neural regeneration and motor function recovery in SCI mice, enabling a comprehensive treatment approach for SCI. The feasibility and efficacy of this platform are confirmed through a series of in vitro and in vivo assays, offering new insights and potential avenues for further exploration in the treatment of SCI.

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“…However, studies on the nanoparticles and liposomes of curcumin in drug delivery systems have attempted to significantly improve its solubility, stability, and safety ( Mahmood et al, 2015 ). Based on its pathomechanism, curcumin has been demonstrated to alleviate various acute and chronic neuronal disorders including depression, ischemic stroke, AD, brain injury, and spinal cord injury by regulating neuroprotective pathways and downregulating the inflammatory storm, thereby enhancing neurological functions ( Bhat et al, 2019 ; Ramaholimihaso et al, 2020 ; Saleh et al, 2022 ; Gu et al, 2023 ). In ischemic stroke, curcumin has upregulated the expression of synaptic remodeling proteins, decreased brain infarct size, and enhanced BBB permeability ( Wu et al, 2021 ), as well as the release of neurotransmitters and neurotrophic substances by curcumin-upregulated signal pathways for neuronal regeneration ( Lan et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Pharmacological intervention of curcumin via the NLRP3 inflammasome in ischemic stroke

Du,

Amin,

et al. 2023

Front. Pharmacol.

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Ischemic-induced neuronal injury arises due to low oxygen/nutrient levels and an inflammatory response that exacerbates neuronal loss. NOD-like receptor family pyrin domain-containing 3 (NLRP3) is an important regulator of inflammation after ischemic stroke, with its inhibition being involved in nerve regeneration. Curcumin, a main active ingredient in Chinese herbs, plays a positive role in neuronal repair and neuroprotection by regulating the NLRP3 signaling pathway. Nevertheless, the signaling mechanisms relating to how curcumin regulates NLRP3 inflammasome in inflammation and neural restoration following ischemic stroke are unknown. In this report, we summarize the main biological functions of the NLRP3 inflammasome along with the neuroprotective effects and underlying mechanisms of curcumin via impairment of the NLRP3 pathway in ischemic brain injury. We also discuss the role of medicinal interventions that target the NLRP3 and potential pathways, as well as possible directions for curcumin therapy to penetrate the blood–brain barrier (BBB) and hinder inflammation in ischemic stroke. This report conclusively demonstrates that curcumin has neuroprotective properties that inhibit inflammation and prevent nerve cell loss, thereby delaying the progression of ischemic brain damage.

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Multiple mechanisms of curcumin targeting spinal cord injury

Cited by 15 publications

References 176 publications

Pyroptosis in Spinal Cord Injury: Implications for Pathogenesis and Therapeutic Approaches

Pyroptosis in Spinal Cord Injury: Implications for Pathogenesis and Therapeutic Approaches

Engineered Macrophage Membrane‐Coated Nanoparticles with Enhanced CCR2 Expression Promote Spinal Cord Injury Repair by Suppressing Neuroinflammation and Neuronal death

Pharmacological intervention of curcumin via the NLRP3 inflammasome in ischemic stroke

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