Multiple morphologies of a poly(methyl methacrylate)‐block‐poly(N,N‐dimethyl aminoethyl methacrylate) copolymer with pH‐responsiveness and thermoresponsiveness

Abstract

We successfully prepared a series of pH-responsive and thermoresponsive poly(methyl methacrylate) (PMMA)-block-poly (N,N-dimethyl aminoethyl methacrylate (PDMAEMA) copolymers via reversible addition-fragmentation chain-transfer polymerization with PMMA as a macro chain-transfer agent. Control over the chain length of PDMAEMA allowed the morphological transformation of PMMA-b-PDMAEMA. The critical water content and critical micelle concentration also depended on the length of the PDMAEMA block. UV-visible and fluorescence spectrum analyses indicated that the PMMA-b-PDMAEMA copolymer exhibited a lower critical solution temperature type phase transition in water. The particle size of PMMA-b-PDMAEMA was dominated by the pH value, as evidenced by dynamic light scattering and transmission electron microscopy. In addition, the PMMA-b-PDMAEMA copolymers exhibited good reversible thermoresponsive behavior between 33 and 38 C.

Polymer N-Heterocyclic Carbene (NHC) Ligands for Silver Nanoparticles

“…The C CWC of PMMA–NHC–AgNPs is 18% in DMF. This result is close to the C CWC of PMMA as reported previously . The red shift of UV–vis is indicative of the formation of AgNP aggregates.…”

Synthesis approaches of amphiphilic copolymers for spherical micelle preparation: application in drug delivery

“…The application of reversible thermo-responsivity of copolymers along with the induced pH-sensitivity by the protonation of PDMAEMA in acidic media can be promising to develop novel drug carriers. 80 Yuman and Peng obtained a triblock dual responsive copolymer through the RAFT reaction by creating a disulfide bond between pyridyldisulfide ethyl methacrylate (PDSM) and thiolated doxorubicin (DOX-SH) to obtain MAL-DOX. The reason for introducing disulfide bonds was to provide structural sensitivity to GSH.…”

Playing construction with the monomer toy box for the synthesis of multi‐stimuli responsive copolymers by reversible deactivation radical polymerization protocols

“…In the recent examples herein, responses to external triggers and hydrophilic/hydrophobic balance are covered by materials that are solely based on “common” monomers, for example, OEGMA, HEMA, AA, AN, hydrophobic methacrylates, styryl monomers, NIPAAm, DMAEMA, PDEA, and so forth. PMMA‐ b ‐PDMAEMA with different DMAEMA block lengths exhibit dual and interrelated pH and thermal sensitivity and form aggregates of different morphologies 204 . POEGMA‐ b ‐PBnMA‐ b ‐PDEA are self‐assembling “breathing” terpolymers; 205 miktoarm terpolymers star‐ (PEG‐PSt‐PDEA) forms interesting morphologies and is CO 2 ‐responsive; 206 POEGMA‐ b ‐PHPMA‐ b ‐PDMAEMA exhibits self‐assembly and dual temperature/CO 2 responsivity 207 .…”