Multiple myeloma and chronic myelomonocytic leukaemia developing in a patient with autoimmune disease

Abstract

A 64-year-old lady with a personal and family history of autoimmune disease developed chronic myelomonocytic leukaemia and multiple myeloma simultaneously. Her sister died of acute myelomonocytic leukaemia, but showed no evidence of autoimmune disease. It is possible that chronic immunological stimulation, perhaps by an autoantigen, may predispose toward malignant transformation in both plasma cell and monocyte series. However, the present observations raise the alternative possibility of a primary disorder of monocytes that predisposes toward both autoimmune disease and a clonal disorder of plasma cells.

Chronic myelomonocytic leukemia preceding high‐grade immunoblastic lymphoma

“…To the Editor: Chronic myelomonocytic leukemia (CMML) is a relatively uncommon type of myelodysplastic syndrome. The association of CMML and lymphoid neoplasia has been reported but is extremely rare (1)(2)(3)(4). We report a patient who developed a highgrade immunoblastic lymphoma 6 months after being diagnosed as suffering from CMML.…”

“…This patient presented with typical features of CMML and 6 months later developed stage IV highgrade immunoblastic lymphoma. On reviewing the literature we found some reports showing association of CMML and myeloma or low-grade lymphoid malignancy (1)(2)(3)(4). To our knowledge, an association of CMML and an aggressive lymphoma has not yet been reported.…”