Multiple myeloma presenting as extensive limb gangrene

Abdulla, Mansoor C; Nair, Lekha K; Narayan, Ram; Das, Anitha

doi:10.4103/1658-5127.141999

Cited by 4 publications

(2 citation statements)

References 7 publications

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“…The National Comprehensive Cancer Network (NCCN) recommends maintenance rituximab for patients who have partial or minor response to initial treatment. A randomized phase 3 trial reported that median progression-free survival (PFS) was longer with maintenance rituximab though statistical significance for this difference was not reached [ 10 ]. Furthermore, assessing the clinical response to induction therapy in this patient was difficult as irreversible gangrene occurred prior to chemotherapy administration.…”

Section: Discussionmentioning

confidence: 99%

A Case of Type 1 Cryoglobulinemia With Lymphoplasmacytic Lymphoma and Dry Gangrene

Rao,

Syed,

Garrido

et al. 2024

Cureus

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Lymphoplasmacytic lymphoma (LPL) is an uncommon condition, accounting for only 2% of all non-Hodgkin's lymphoma cases. Individuals with LPL face the risk of vascular blockage when associated with type I cryoglobulinemia, leading to related symptoms. Until now, no instances of LPL with dry gangrene have been documented. However, we present a rare case involving LPL accompanied by dry gangrene in both the right upper extremity (RUE) and left lower extremity (LLE). The patient was effectively managed using a combination of chemotherapy, steroids, plasmapheresis, and salvage surgery.

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Section: Discussionmentioning

confidence: 99%

A Case of Type 1 Cryoglobulinemia With Lymphoplasmacytic Lymphoma and Dry Gangrene

Rao,

Syed,

Garrido

et al. 2024

Cureus

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“…[ 3 4 ] Hematological malignancies including leukemias, lymphomas, and myeloma are reported to be associated with digital ischemia. [ 5 6 7 ] Myeloproliferative disorders including chronic myeloid leukemia and essential thrombocythemia were previously reported to be associated with digital ischemia. [ 8 9 ] The proposed mechanism in these cases of digital gangrene was thrombocytosis.…”

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confidence: 99%

Chronic myelomonocytic leukemia presenting as upper limb gangrene

Priya

Abdulla

Umashankar

2018

South Asian J Cancer

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Digital Necrosis as Initial Manifestation of Multiple Myeloma: An Unusual Case Report

Zrikem¹,

Raissi²,

Idrissi³

et al. 2022

EMJ Hematol

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Clinical manifestations of multiple myeloma are variable. The authors report a 68-year-old female who presented to the hospital with bilateral digital necrosis and dry gangrenous toes in both left and right feet. She was diagnosed with IgA-λ multiple myeloma associated with Type I cryoglobulinaemia. Emergency management consisted in hyperhydration (plasmapheresis was not available) and thromboprophylaxis. Necrotic digits were amputated. Chemotherapy (bortezomib, lenalidomide, and dexamethasone) was started with good initial evolution. This uncommon presentation can easily be missed, and clinicians should be aware of a possible underlying malignancy.

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Multiple myeloma presenting as extensive limb gangrene

Cited by 4 publications

References 7 publications

A Case of Type 1 Cryoglobulinemia With Lymphoplasmacytic Lymphoma and Dry Gangrene

A Case of Type 1 Cryoglobulinemia With Lymphoplasmacytic Lymphoma and Dry Gangrene

Chronic myelomonocytic leukemia presenting as upper limb gangrene

Digital Necrosis as Initial Manifestation of Multiple Myeloma: An Unusual Case Report

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