Multiple myeloma terminating in acute leukemia

Rosner, Fred; Grünwald, Hans

doi:10.1016/0002-9343(74)90171-5

Cited by 171 publications

(19 citation statements)

References 77 publications

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“…The later development of acute leukemia in patients with multiple myeloma (MM) is well recognized [1][2][3][4][5][6] and has ge nerally been attributed to the oncogenic potential of irradia tion and chemotherapeutic agents. However, in the past year, we have observed three patients who developed non-hemato logic malignancies with multiple myeloma; one with simul taneous renal cell neoplasm and the remaining two patients with adenocarcinoma of the colon and the lung, suggesting that perhaps multiple meyloma itself might be a risk factor for the development of other malignancies.…”

Section: Introductionmentioning

confidence: 99%

Second Malignancies in Patients with Multiple Myeloma

Law¹,

Blom²

1977

Oncology

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Seven patients with multiple myeloma who developed a second neoplasm are presented. There were four patients with acute leukemia and three patients with non-hematologic neoplasms. The patients with acute leukemia were among the longest survivors (median duration ≈ 72 months) and the response to anti-leukemic therapy in these patients was generally poor. Of the three patients with non-hematologic neoplasms, one patient was observed with simultaneous renal cell carcinoma and the other two patients developed adenocarcinoma of the colon and lung subsequently. In addition, two patients with mammary carcinoma who subsequently developed multiple myeloma were included. Literature was reviewed and the possibility that multiple myeloma itself might be a risk factor for the development of other malignancies was discussed.

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Section: Introductionmentioning

confidence: 99%

Second Malignancies in Patients with Multiple Myeloma

Law¹,

Blom²

1977

Oncology

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“…The coexistence of plasma cell dyscrasia with leukemia has been widely reviewed [1][2][3]. A relatively large number of cases of acute nonlymphoblastic leukemia have been reported in patients with plasma cell dyscrasias including multiple myeloma and Wal denstrom's macroglobulinemia.…”

Section: Discussionmentioning

confidence: 99%

“…The coexistence of plasma cell dyscrasia with leukemia has usually been described in patients with myeloma receiving long-term cytotoxic therapy [1][2][3][4][5]. The simultaneous occurrence of these two malignancies, unre lated to therapy, is a rare association and points to the possibility of a disorder of the pluripotent malignant stem cell with aber rant differentiation.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Presentation of Plasma Cell and Monocytic Leukemia with a Subacute Clinical Course

Naparstek¹,

Leiserowitz²,

Gamliel³

et al. 1982

Acta Haematol

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A rare case of simultaneous presentation of monocytic and plasma cell leukemia is reported. Cytochemistry, transmission and scanning electron microscopy confirmed the presence of a dual population consisting of monoblasts and plasma cells. Monoblasts contained nonspecific esterases, secreted lysozyme and showed dense bodies and surface ruffles under the scanning electron microscope, while the plasma cells secreted IgG kappa para-protein, contained rough endoplasmic reticulum, and showed surface blebs with microvilli. Another unusual feature of this case was the relatively chronic course of the disease, lasting 15 months after initial diagnosis.

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“…In contrast to Hodgkin's disease [21,24] and multiple myeloma [15,20], there are very few well-documented cases of NHL terminating in AML [3,14,28]. Involvement of the blood, however, is relatively com mon in NHL [9,18,21,27].…”

Section: Discussionmentioning

confidence: 99%