Multiple object tracking and pupillometry reveal deficits in both selective and intensive attention in unilateral spatial neglect

Walle, Kjersti Mæhlum; Nordvik, Jan Egil; Espeseth, Thomas; Becker, Frank; Laeng, Bruno

doi:10.1080/13803395.2018.1536735

Cited by 7 publications

(4 citation statements)

References 66 publications

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“…The age-related gradual loss in the ability of auditory localization has also been studied using fixations [221]. The study of pupillary responses in a multiobject tracking task has revealed stroke-related cognitive deficits in addition to impairments in spatial attention [222].…”

Section: Cognition and Cognitive Ergonomicsmentioning

confidence: 99%

Aging and Eye Tracking: in the Quest for Objective Biomarkers

Marandi

Gazerani

2019

Future Neurol.

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Recent applications of eye tracking for diagnosis, prognosis and follow-up of therapy in age-related neurological or psychological deficits have been reviewed. The review is focused on active aging, neurodegeneration and cognitive impairments. The potential impacts and current limitations of using characterizing features of eye movements and pupillary responses (oculometrics) as objective biomarkers in the context of aging are discussed. A closer look into the findings, especially with respect to cognitive impairments, suggests that eye tracking is an invaluable technique to study hidden aspects of aging that have not been revealed using any other noninvasive tool. Future research should involve a wider variety of oculometrics, in addition to saccadic metrics and pupillary responses, including nonlinear and combinatorial features as well as blink- and fixation-related metrics to develop biomarkers to trace age-related irregularities associated with cognitive and neural deficits.

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Section: Cognition and Cognitive Ergonomicsmentioning

confidence: 99%

Aging and Eye Tracking: in the Quest for Objective Biomarkers

Marandi

Gazerani

2019

Future Neurol.

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“…Specifically, we estimated activation patterns during multiple object tracking (MOT) at baseline, before initiating training (on average 4 weeks after baseline measure), and after a three‐week intervention. The MOT task offers a promising tool for assessing and manipulate converging activation patterns across attention and working memory tasks in both healthy controls and stroke patients (Dørum et al, 2016; Pylyshyn & Strom, 1988; Walle, Nordvik, Espeseth, Becker, & Laeng, 2019). MOT robustly recruit brain areas (Alnæs et al, 2014) comparable with activations associated with Cogmed training (Olesen, Westerberg, & Klingberg, 2004), including canonical task‐positive and task‐negative brain networks.…”

Section: Introductionmentioning

confidence: 99%

Reliability, sensitivity, and predictive value of fMRI during multiple object tracking as a marker of cognitive training gain in combination with tDCS in stroke survivors

Kolskår

Richard

Alnæs

et al. 2020

Human Brain Mapping

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Computerized cognitive training (CCT) combined with transcranial direct current stimulation (tDCS) has showed some promise in alleviating cognitive impairments in patients with brain disorders, but the robustness and possible mechanisms are unclear. In this prospective double‐blind randomized clinical trial, we investigated the feasibility and effectiveness of combining CCT and tDCS, and tested the predictive value of and training‐related changes in fMRI‐based brain activation during attentive performance (multiple object tracking) obtained at inclusion, before initiating training, and after the three‐weeks intervention in chronic stroke patients (>6 months since hospital admission). Patients were randomized to one of two groups, receiving CCT and either (a) tDCS targeting left dorsolateral prefrontal cortex (1 mA), or (b) sham tDCS, with 40s active stimulation (1 mA) before fade out of the current. Of note, 77 patients were enrolled in the study, 54 completed the cognitive training, and 48 completed all training and MRI sessions. We found significant improvement in performance across all trained tasks, but no additional gain of tDCS. fMRI‐based brain activation showed high reliability, and higher cognitive performance was associated with increased tracking‐related activation in the dorsal attention network and default mode network as well as anterior cingulate after compared to before the intervention. We found no significant associations between cognitive gain and brain activation measured before training or in the difference in activation after intervention. Combined, these results show significant training effects on trained cognitive tasks in stroke survivors, with no clear evidence of additional gain of concurrent tDCS.

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“…Specifically, we estimated activation patterns during multiple object tracking (MOT) at baseline, before initiating training (on average 4 weeks after baseline measure), and after a three-week intervention. The multiple object tracking (MOT) task offers a promising tool for assessing and manipulate converging activation patterns across attention and working memory tasks in both healthy controls and stroke patients Pylyshyn and Strom, 1988;Walle et al, 2019). MOT robustly recruit brain areas comparable with activations associated with Cogmed training (Olesen et al, 2004), including canonical task-positive and task-negative brain networks.…”

Section: Introductionmentioning

confidence: 99%

Reliability, sensitivity and predictive value of fMRI during multiple object tracking as a marker of cognitive training gain in combination with tDCS in stroke survivors

Kolskår

Richard

Alnæs

et al. 2019

Preprint

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Computerized cognitive training (CCT) combined with transcranial direct current stimulation (tDCS) has showed some promise in alleviating cognitive impairments in patients with brain disorders, but the robustness and possible mechanisms are unclear. In this prospective doubleblind randomized clinical trial, we investigated the feasibility and effectiveness of combining CCT and tDCS, and tested the predictive value of and training-related changes in fMRI-based brain activation during attentive performance (multiple object tracking) obtained before, during and after the three-weeks intervention. Patients were randomized to one of two groups, receiving CCT and either (1) tDCS targeting left dorsolateral prefrontal cortex (1 mA), or (2) sham tDCS, with 40s active stimulation (1 mA) before fade out of the current. 77 patients were enrolled in the study, 54 completed the cognitive training, and 48 completed all training and MRI sessions. We found significant improvement in performance across all trained tasks, but no additional gain of tDCS. fMRI-based brain activation showed high reliability, and higher cognitive performance was associated with increased tracking-related activation in the dorsal attention network and DMN as well as anterior cingulate after compared to before the intervention. We found no significant associations between cognitive gain and brain activation measured before training or in the difference in activation after intervention.Combined, these results show significant training effects on cognitive tasks in stroke survivors, with no clear evidence of additional gain of concurrent tDCS.

show abstract

Multiple object tracking and pupillometry reveal deficits in both selective and intensive attention in unilateral spatial neglect

Cited by 7 publications

References 66 publications

Aging and Eye Tracking: in the Quest for Objective Biomarkers

Aging and Eye Tracking: in the Quest for Objective Biomarkers

Reliability, sensitivity, and predictive value of fMRI during multiple object tracking as a marker of cognitive training gain in combination with tDCS in stroke survivors

Reliability, sensitivity and predictive value of fMRI during multiple object tracking as a marker of cognitive training gain in combination with tDCS in stroke survivors

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