2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) 2013
DOI: 10.1109/embc.2013.6609485
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Multiple optical stimulation to neuron using Si opto-neural probe with multiple optical waveguides and metal-cover for optogenetics

Abstract: We have developed a Si opt-neural probe with multiple waveguides and metal cover for highly accurate optical stimulation. This neural probe had 16 recording sites, three optical waveguides, and metal cover for suppressing light leakage. We evaluated electrochemical properties of the recording sites, and confirmed that the neural probe had suitable characteristics for neural recording. We also demonstrated the optical stimulation to the neurons expressing ChR2 using our probe. As a result, we succeeded multisit… Show more

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Cited by 9 publications
(8 citation statements)
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“…In neuroscience research, this probe will enable greater stimulation power and stimulation of more sites than conventional probes. (10,(12)(13)(14) Power-limited stimulation may not affect neural circuit function. Studies with limitation of the number of stimulations may not result in a comprehensive study across all layers.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In neuroscience research, this probe will enable greater stimulation power and stimulation of more sites than conventional probes. (10,(12)(13)(14) Power-limited stimulation may not affect neural circuit function. Studies with limitation of the number of stimulations may not result in a comprehensive study across all layers.…”
Section: Discussionmentioning
confidence: 99%
“…(11) Also, recording probes with waveguides have been developed. (12)(13)(14) These probes have multiple recording areas and one or multiple waveguides. When these devices are employed, a high-intensity light source is required because the output power of the tip is diluted by the loss of input coupling.…”
Section: Introductionmentioning
confidence: 99%
“…Among various materials, Parylene-C (PA) is one of the most prevailing packaging materials for biomedical implants [ 14 , 15 , 16 , 17 , 18 ]. SiO 2 [ 19 , 20 , 21 , 22 ], and Si 3 N 4 [ 23 , 24 , 25 ] are usually used as insulating layers in silicon based neural probes as well as an encapsulation protective layer to protect microelectronics from corrosive environments such as body fluids. However, the packaging performances of these films have not been studied systematically.…”
Section: Introductionmentioning
confidence: 99%
“…In the past few decades, various kinds of neural probes have been developed for the recording and stimulation of neurons to study brain functions and to cure brain diseases such as Parkinson's disease and epilepsy. [1][2][3][4][5][6] Particularly, a Si neural probe fabricated with micro-and nanotechnologies is one of the most important tools because of its various functions such as optical stimulation, 5,[7][8][9] drug delivery, 5,[10][11][12] and so forth. [13][14][15][16][17] Meanwhile, the insertion of a Si neural probe may damage brain tissues, and the quality of recording signals is degraded by the formation of glial scar tissues around the Si neural probe and by neuronal cell loss.…”
Section: Introductionmentioning
confidence: 99%