Multiple origin of minute bronchiolargenic carcinomas.Report of a case

Spain, David M.; Parsonnet, Victor

doi:10.1002/1097-0142(195103)4:2<277::aid-cncr2820040212>3.0.co;2-n

Cited by 54 publications

(3 citation statements)

References 4 publications

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“…All the usual positive and negative tissue controls were used, including immunolabelling with aliquots of antiserum preabsorbed by overnight incubation at 4'C with a range of concentrations of its homologous antigen (table 1). In all cases immunolabelling was quenched by addition of [5][6][7][8][9][10][11][12][13][14][15] nmol/ml of antigen.…”

Section: Methodsmentioning

confidence: 99%

Appropriate and inappropriate neuroendocrine products in pulmonary tumourlets.

Gosney

Green

Taylor

1990

Thorax

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Pulmonary tumourlets are focal aggregates of neuroendocrine cells that occur in the periphery of the lung and may be associated with chronic inflammation and scarring. Six such lesions were seen in five lungs from a series of 35 pairs of lungs studied at necropsy. MethodsTumourlets were sought in the lungs of 35 patients coming to necropsy, the only criterion for selection being that the necropsy was performed within 48 hours of death. In each case the left lung was distended with Bouin's solution, allowed to fix for 48 hours, and cut into 1 cm sagittal slices. At least 12 random blocks were then taken from each, a numbered perspex grid being placed over each slice, and a table of random numbers being used to select the blocks, with the proviso that large airways and vessels were avoided. Multiple blocks were taken from the non-distended right lungs at the time of the necropsy and these were also fixed in Bouin's solution for 48 hours. After being embedded in paraffin wax sections were stained with haematoxylin and eosin and the elastic van Gieson method and examined by light microscopy.When a tumourlet was discovered, serial sections of the block in which it was contained were cut and immunochemically labelled for neurone specific enolase and protein gene product 9 5, markers of pulmonary neuroendocrine cells,67 and a series of products of neuroendocrine cells (table 1) by the peroxidase-antiperoxidase technique.8 These substances were chosen for study because either they are found in the neuroendocrine cells of the normal human lung (gastrin releasing peptide, calcitonin, leucineenkephalin, and 5-hydroxytryptamine)9"' or

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Section: Methodsmentioning

confidence: 99%

Appropriate and inappropriate neuroendocrine products in pulmonary tumourlets.

Gosney

Green

Taylor

1990

Thorax

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“…Except for a few reported cases of small, peripherally situated tumours (Gray and Cordonnier, 1929;Stewart and Allison, 1943;James and Pagel, 1944;Petersen, Hunter, and Sneeden, 1949;Spain and Parsonnet, 1951;Prior and Jones, 1952) arnd one describing two minute growths in main bronchi (Aufses and Neuhof, 1952), very little attempt has been made to trace the origin of this very common tumour by looking for the earliest stages in its development. Because the larger bronchi are so frequently involved in the later spread of the disease it is usually assumed that most growths started in the main bronchi.…”

mentioning

confidence: 99%

A Study of the Origin and Development of Lung Cancer

Raeburn¹,

Spencer²

1953

Thorax

108

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“…They are located in the vicinity of the bronchioles, with metastasis being an uncommon feature of pulmonary tumorlets. We are aware of only a few cases of pulmonary tumorlets with metastasis to peribronchial lymph nodes (2)(3)(4)(5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

An Underrated Potential Risk of Bronchiectasis: Lymph Node Metastasis of a Pulmonary Tumorlet

Doğan

Kara²,

Gundogdu

et al. 2009

Acta Chirurgica Belgica

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Pulmonary tumorlets occur as the result of extensive scar caused by bronchiectasis or other inflammatory processes. They are minute lesions found in close association with the bronchioles and may rarely metastasize to lymph nodes. We present a 35-year-old male patient who underwent bilobectomy inferior with a diagnosis of bronchiectasis of 20 years duration. Histologic examination showed cystic bronchiectasis with areas of multiple neuro-endocrine tumor-lets in addition to metastatic peribronchial lymph nodes. We emphasize the significance of early surgical treatment of bronchiectasis showing little to no response to medical therapy as well as peribronchial lymph node dissection.

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Multiple origin of minute bronchiolargenic carcinomas.Report of a case

Cited by 54 publications

References 4 publications

Appropriate and inappropriate neuroendocrine products in pulmonary tumourlets.

Appropriate and inappropriate neuroendocrine products in pulmonary tumourlets.

A Study of the Origin and Development of Lung Cancer

An Underrated Potential Risk of Bronchiectasis: Lymph Node Metastasis of a Pulmonary Tumorlet

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