Multiple palisaded encapsulated neuromas in a child without other associated abnormalities

Moore, Rachael L.; White, Clifton R.

doi:10.1016/j.jaad.2009.01.036

Cited by 17 publications

(20 citation statements)

References 8 publications

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“…reported a 45‐year‐old woman with multiple cutaneous neuromas associated with medullary thyroid carcinoma who had a mutation of RET proto‐oncogene; they first demonstrated the clear clinical association between MEN 2b syndrome and multiple cutaneous neuromas in the absence of mucosal neuroma. On the contrary, a few cases of multiple cutaneous and mucocutaneous neuromas that are apparently not related to MEN 2b syndrome have been reported, as in our present case . Misago et al .…”

Section: Discussioncontrasting

confidence: 68%

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Multiple palisaded encapsulated neuromas in siblings: A case report and review of the published work

Liu

Song

2015

The Journal of Dermatology

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Palisaded encapsulated neuroma (PEN) is an uncommon, typically solitary, cutaneous neural neoplasm. Multiple mucocutaneous neuromas are usually seen in multiple endocrine neoplasia (MEN) 2b syndrome. Multiple cutaneous PEN in adult patients with or without features of MEN 2b are extremely rare, with only a few cases described. We report a case of multiple PEN in siblings of the same family with no apparent systemic abnormalities, and review the relevant published work to explore its clinical and pathogenic features and the relationship between multiple PEN and MEN 2b type neuroma (multiple mucocutaneous neuromas seen in MEN 2b syndrome).

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Section: Discussioncontrasting

confidence: 68%

“…To our knowledge, only 10 such cases have been reported in the English published work. [2][3][4][5][6][7][8][9][10][11] We summarized the age at diagnosis, sex, the number of lesions and the relevant accompanying disease of these cases (Table 1). Patient age at presentation ranged 7-70 years, with the average age of 39.6 years.…”

Section: Case Reportmentioning

confidence: 99%

Multiple palisaded encapsulated neuromas in siblings: A case report and review of the published work

Liu

Song

2015

The Journal of Dermatology

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“…described multiple, chronic cutaneous lesions with the histological appearance of solitary circumscribed neuromas in a 50‐year‐old male. Two paediatric cases, also with multiple solitary circumscribed neuromas, are worthy of note …”

Section: Discussionmentioning

confidence: 95%

Expanding the clinical spectrum of dermal hyperneury: report of nine new cases and a review of the literature

et al. 2019

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Aims Dermal hyperneury is defined as the hypertrophy of small nerves in the dermis. It has been described in a variety of settings. We present a series of nine new cases with a distinctive clinical presentation and review the existing literature. The aim of the study was to summarise the clinical, histopathological and immunohistochemical findings in a case series of dermal hyperneury with unique clinical presentation. Methods and results Nine cases were identified from the referral practice of one of the authors. Clinical characteristics, including demographic details, were collated. The histopathological features and novel immunohistochemical findings were analysed. Four cases presented with multiple skin lesions. Clinical evaluation revealed no associated syndromic stigmata. The histology in all cases was that of dermal hyperneury. Immunohistochemistry for phosphatase and tensin homologue (PTEN) and RET was supportive of the lack of syndromic association. Conclusion The presentation of dermal hyperneury with multiple cutaneous lesions and no syndromic associations is distinctive, and no study with PTEN and RET immunohistochemistry has previously been reported. Comparisons with recent reports of multiple non‐syndromic mucocutaneous neuromas are discussed.

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“…[1] Clinically it presents as non-characteristic, solitary or multiple nontender, skin-colored papule, mostly over the face and neck areas, rarely on the mucosa (oral, nasal or genital), trunk or proximal extremities, and more rarely on the acral parts. [12]…”

Section: Discussionmentioning

confidence: 99%

“…[1] Multiple mucosal neuromas and rarely multiple cutaneous neuromas may be associated with MEN type 2B (mutation in exon 16 in RET-proto-oncogene) or Cowden and Bannayan-Riley-Ruvalcaba syndromes (mutation in tumor suppressor gene PTEN). [21]…”

Section: Discussionmentioning

confidence: 99%

SkIndia Quiz 4 - Asymptomatic sessile skin colored nodule over columella of nose

Gutte

Garg

Doshi

et al. 2011

Indian Dermatol Online J

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Multiple palisaded encapsulated neuromas in a child without other associated abnormalities

Cited by 17 publications

References 8 publications

Multiple palisaded encapsulated neuromas in siblings: A case report and review of the published work

Multiple palisaded encapsulated neuromas in siblings: A case report and review of the published work

Expanding the clinical spectrum of dermal hyperneury: report of nine new cases and a review of the literature

SkIndia Quiz 4 - Asymptomatic sessile skin colored nodule over columella of nose

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