Multiple peptide synthesis using cellulose-based carriers: Synthesis of substance P - diastereoisomers and their histamine-releasing activity

Schmidt, Margit; Eichler, Jutta; Odarjuk, J.; Krause, Eberhard; Beyermann, Michael; Bienert, Michael

doi:10.1016/s0960-894x(01)80228-6

Cited by 16 publications

(9 citation statements)

References 19 publications

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“…Besides the commonly used resin beads9, 10 arranged in various types of reaction vessels such as polypropylene bags,11 syringes,12 microtiter plate wells,13 and synthesizer reactor vessels, a variety of other segmentable carriers have been described for such syntheses 14. These include polymeric pins,15 planar surfaces in the shape of glass slides,16 cellulose,17, 18 and cotton sheets19, 20 as well as polymeric films,21 disks,22, 23 and membranes 24, 25…”

Section: Introductionmentioning

confidence: 99%

Coherent membrane supports for parallel microsynthesis and screening of bioactive peptides

Wenschuh¹,

Volkmer

Schmidt³

et al. 2000

Biopolymers

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196

111

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Since its invention the SPOT‐synthesis methodology has become one of the most efficient strategies for the miniaturized assembly of large numbers of peptides. The combination of a facile synthetic method with high throughput solid‐ and solution‐phase screening assays qualifies the SPOT‐technique as a valuable tool in biomedical research. Recent developments such as the introduction of novel polymeric surfaces, new linker and cleavage strategies as well as automated robot systems extended the scope of practical chemical reactions that can be accommodated as well as the numbers of compounds obtainable by this technique. Thus, highly complex spatially addressed compound arrays have become accessible. Together with the introduction of novel screening assays, the method is excellently suited to elucidate recognition events on the molecular level. © 2000 John Wiley & Sons, Inc. Biopolymers (Pept Sci) 55: 188–206, 2000

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Section: Introductionmentioning

confidence: 99%

Coherent membrane supports for parallel microsynthesis and screening of bioactive peptides

Wenschuh¹,

Volkmer

Schmidt³

et al. 2000

Biopolymers

Self Cite

196

111

View full text Add to dashboard Cite

show abstract

“…Solid carriers capable of convenient compartmentalization and therefore parallel multiple synthesis include functionalized polymeric sheets and disks [128,129], membranes [130], paper, cellulose [61,131], cotton [132,133], or functionalized acrylate-grafted polypropylene fabric [134]. Some of them will be mentioned later since they act as the support of choice for array syntheses.…”

Section: Directed Sortingmentioning

confidence: 99%

Combinatorial/Library Peptide Synthesis

Lebl

2011

Amino Acids, Peptides and Proteins in Organic Chemistry

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“…The purest form of cellulose, cotton, was found to be a convenient solid-phase support, especially for multiple peptide synthesis 51,55,56 and the generation of peptide libraries. 57,58 The cotton strips may be conveniently modified chemically and provide an inexpensive solid support.…”

Section: Multiple Peptide Synthesis On Cotton Stripsmentioning

confidence: 99%

Solid‐phase synthesis on planar supports

Lebl¹

1998

Biopolymers

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Multiple peptide synthesis using cellulose-based carriers: Synthesis of substance P - diastereoisomers and their histamine-releasing activity

Cited by 16 publications

References 19 publications

Coherent membrane supports for parallel microsynthesis and screening of bioactive peptides

Coherent membrane supports for parallel microsynthesis and screening of bioactive peptides

Combinatorial/Library Peptide Synthesis

Solid‐phase synthesis on planar supports

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