Solid‐phase synthesis on planar supports

Solid-Phase Methods for the Microwave-Assisted Synthesis of Heterocycles

“…For use in microwave-mediated SPOS, the resin needs to have good stability under high temperature conditions. Various supports have proven useful for SPOS, and the scope of reaction conditions with which they are compatible has been explored [45][46][47].…”

“…Microwave-assisted solid-phase parallel synthesis has also been reported using multi-well filter-bottom polypropylene plates [45,155]. However, it should be mentioned that the thermal instability of the polypropylene plates is a limitation of this setup.…”

Centrifugation Based Automated Synthesis Technologies

“…Tilted plate centrifugation as a method for high-throughput synthesis was first presented at LabAutomation 98 in San Diego. 16 It was developed as part of the high-throughput synthesis program at Trega Biosciences and was aimed at the synthesis of libraries of small organic molecules, presented as individual compounds in the wells of microtiter plates. Since this methodology was understood by Trega as secondary to the methodology of surface suction [3][4] developed at the same time, centrifugal synthesizer development was pursued by Spyder Instruments, Inc. with the funding provided by the National Institutes of Health.…”

Microwave-Facilitated SPOT-Synthesis of Antibacterial Dipeptoids

“…15 In contrast to the polystyrene resins usually applied in solid-phase synthesis, the hydrophilic cellulosic membranes are easy to manipulate during the synthesis and washing steps and have surprisingly high mechanical stability. 16 In addition, the hydrophilic cellulose is compatible with a range of biological screening methods directly on the carrier. The introduction of heating systems such as drying ovens and the unconventional microwave irradiation have also significantly reduced long reaction times.…”