Multiple primary malignancies involving colorectal cancer—clinical characteristics and prognosis with reference to surveillance

Abstract

The frequent association between colorectal cancer and gastric cancer suggests an inclusion of gastrofiberscope when surveillancing patients with colorectal cancer in Korean population. Second primary cancers may develop even 10 years after the initial operation; thus, a need for lifelong surveillance even more than 5 years may be necessary.

Polymorphisms of cancer-related genes and risk of multipleprimary malignancies involving colorectal cancer

“…The colon and rectum are the most commonly reported organs for multiple primary cancer development, and multiple primary malignancy involving colorectal cancer is the most frequently seen form of multiple primary cancer (17). Patients with multiple primary colorectal cancers have been shown to have a significantly worse prognosis than those with single primary colorectal cancers (18). However, few studies have investigated the cause of multiple primary malignancies involving colorectal cancer.…”

Synchronous Breast and Rectal Cancers in a Man

“…A number of population-based studies evaluated the association between breast and colorectal cancer in the reverse direction, namely the risk of second primary non-colorectal cancer occurring after colorectal adenocarcinoma [10, 11, 12, 13, 14, 15. The incidence of synchronous or metachronous non-colorectal cancer was 2–6%.…”

“…The incidence of synchronous or metachronous non-colorectal cancer was 2–6%. The most common malignancies seen were cancer of the stomach, especially in countries with a high incidence of gastric cancer, intestinal, kidney, prostate, uterine, cervical and ovarian cancer [10, 11, 12, 13, 14, 15. The majority of those secondary malignancies developed within 3 years after the primary colorectal cancer, although some developed 5 years or more after the initial diagnosis of colorectal cancer.…”

Clinical and pathological evaluation of patients with prostate and colorectal cancer five or more years after curative resection

“…1 The colorectum is one of the most common sites of new cancer cases and related deaths in both men and women in Korea. 2,3 During the past two decades, the survival rate of patients with CRC has improved significantly due to both an increased incidence of discovering CRC early and the development of new chemotherapeutic target agents, such as cetuximab and bevacizumab. 2,3 During the past two decades, the survival rate of patients with CRC has improved significantly due to both an increased incidence of discovering CRC early and the development of new chemotherapeutic target agents, such as cetuximab and bevacizumab.…”

“…1 The colon is also another common site for multiple primary malignant tumors. 2,3 During the past two decades, the survival rate of patients with CRC has improved significantly due to both an increased incidence of discovering CRC early and the development of new chemotherapeutic target agents, such as cetuximab and bevacizumab. The improvement in the prognosis for CRC has led to an increased incidence of second primary cancers during routine recurrence work-up screening.…”