Multiple radiolucent areas of the jaw

Arendt, Douglas M.; Schaberg, Siegfried J.; Meadows, J. Thomas.

doi:10.1016/s0002-8177(87)54015-6

Cited by 10 publications

(5 citation statements)

References 13 publications

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“…The reported observations should be considered when assessing facial skeletal findings in patients with NF1 in order to differentiate dysplastic, dystrophic, and neoplastic features of the disease. Assessment of the dysplastic component of the mandible in cases of extensive facial PNFs may help to avoid unnecessary resections (68). In addition, the finding justifies withholding major facial reconstructive skeletal measures in the region of an extensive facial PNF in NF1 patients, because the osseous reconstruction may not remain stable.…”

Section: Resultsmentioning

confidence: 99%

Unilateral Creeping Destruction of Deformed Mandibular Ramus and Angle Associated with Extensive Facial Plexiform Neurofibroma in Neurofibromatosis Type 1: A Case Report with Analysis of the Literature for Diagnosing Osteolytic Events of the Mandible in Tumor-suppressor Gene Syndrome

Friedrich

Scheuer²

2018

Anticancer Res

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Neurofibromatosis type (NF1) is an autosomal dominant inherited tumor-suppressor gene syndrome of significant phenotypic variability with probable complete penetrance of the disease. Skeletal malformations of the skull belong to the phenotype of NF1. In the skull, defects of the calvaria and the sphenoid bone are diagnostically groundbreaking findings in NF1. Malformations of the facial skull are usually diagnosed in patients with NF1 in a topographical context with a plexiform neurofibroma (PNF). This report describes the rare occurrence of slowly advancing, unilateral destruction of proportions of the mandible in NF1, with the affected bone segment completely surrounded by a PNF. A malignant process was ruled out as a cause of partial organ loss. Various hypotheses on the pathogenesis of the rare finding are presented.

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Section: Resultsmentioning

confidence: 99%

Unilateral Creeping Destruction of Deformed Mandibular Ramus and Angle Associated with Extensive Facial Plexiform Neurofibroma in Neurofibromatosis Type 1: A Case Report with Analysis of the Literature for Diagnosing Osteolytic Events of the Mandible in Tumor-suppressor Gene Syndrome

Friedrich

Scheuer²

2018

Anticancer Res

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“…Numerous reports have documented the prevalence of NF in the head and neck areas, including the jaws and oral cavity 3–18 . Studies have confirmed the close association between tongue neurofibromas and NF type 1 2 .…”

Section: Discussionmentioning

confidence: 97%

Unusual presentation of a hypoglossal nerve neurofibroma

Patel

McGurk

2009

Oral Surgery

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Neurofibromatosis type 1 genetic disorder is an inherited autosomal dominant trait with variable penetrance and expressivity and occurs in one of every 2000-3300 live births. Neurofibromatosis type 2, on the other hand, afflicts only one in approximately 50 000 people. Within these patients, the frequency of intra-oral involvement of neurofibromas has been reported in a range of 4-7%. Alternatively, neurofibromas in the oral cavity minus the presence of a neurofibromatosis disease has been documented but the prevalence is even less than stated earlier making a solitary neurofibroma of the tongue a rare occurrence. This article reports an unusual presentation of a neurofibroma masquerading as a lipoma with the tumour occurring at the base of the tongue.

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“…Medial depression of the mandibular ramus was reported in another case of neurofibro- matosis. [22] In a study evaluating the images of 10 patients with neurofibromatosis, it was found that the mandibular angle was reduced in 6 cases. Deformity of the condyles was also observed.…”

Section: Discussionmentioning

confidence: 99%

Unilateral linguofacial trunk

Harre Simsar,

Yıldız,

Erdem

et al. 2023

Anatomy

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Neurofibromatosis is an autosomal dominant neurocutaneous syndrome characterized by skin lesions and central or peripheral nervous system tumors. Although neurofibromatosis is a neurocutaneous disease, it also involves multiple systems. For example, bone lesions have been reported in 40% of patients. As in this case, pathologies associated with the mandible and temporomandibular joint in neurofibromatosis are rarely reported in the literature. In our case, we aimed to emphasize that skeletal malformations may also be present in the rich clinical picture of neurofibromatosis. Maxillofacial computed tomography of a 24-year-old female patient who was followed up at Selçuk University Hospital with a diagnosis of neurofibromatosis revealed an appearance compatible with atrophy in the right half of the mandible. The mandibular ramus was 41.27 mm on the right and 53.44 mm on the left; the diameter of the condyloid process was 10.31 mm on the right and 15.71 mm on the left. The joint distance was increased on the right. Radiologic examinations in neurofibromatosis syndrome should be performed considering the possibility of bone lesions. These examinations are especially important for the prevention of pathologic fractures in bones.

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Multiple radiolucent areas of the jaw

Cited by 10 publications

References 13 publications

Unilateral Creeping Destruction of Deformed Mandibular Ramus and Angle Associated with Extensive Facial Plexiform Neurofibroma in Neurofibromatosis Type 1: A Case Report with Analysis of the Literature for Diagnosing Osteolytic Events of the Mandible in Tumor-suppressor Gene Syndrome

Unilateral Creeping Destruction of Deformed Mandibular Ramus and Angle Associated with Extensive Facial Plexiform Neurofibroma in Neurofibromatosis Type 1: A Case Report with Analysis of the Literature for Diagnosing Osteolytic Events of the Mandible in Tumor-suppressor Gene Syndrome

Unusual presentation of a hypoglossal nerve neurofibroma

Unilateral linguofacial trunk

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