Multiple rectal carcinoids with diffuse ganglioneuromatosis

Haraguchi, Masashi; Kinoshita, Hideki; Koori, Miho; Tsuneoka, Noritsugu; Kosaka, Taiichiro; Ito, Yuji; Furui, Junichiro; Kanematsu, Takashi

doi:10.1186/1477-7819-5-19

Cited by 27 publications

(15 citation statements)

References 6 publications

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“…In the Japanese population, rectal NET is the most frequently reported GI tract NET (1). To date, only a few reports of multiple rectal NETs associated with multiple ECMs have been published (2,3,5,6). ECMs may be regarded as the initial phase or intermediate stage of development of a carcinoid tumor (3).…”

Section: Discussionmentioning

confidence: 99%

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Single Rectal Neuroendocrine Tumor Associated with Multiple Endocrine Cell Micronests

et al. 2020

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Although a few reports of neuroendocrine tumor (NET) in the stomach or appendix with surrounding micronests have been published, cases of rectal NET are rare. We herein report a unique case of a patient with single rectal NET treated endoscopically. A pathological examination revealed multiple endocrine cell micronests (ECMs) in the submucosal layer around the main NET lesion. Neither lymph node metastasis nor distant metastasis in computed tomography was observed six years after the treatment. Because case reports of multiple ECM are very rare, the significance of malignancy is unclear. It therefore appears to be necessary to accumulate similar cases.A 53-year-old man with no remarkable medical history of major illness and family history was referred to our hospital for endoscopic treatment of SMT in the rectum. Colonoscopy revealed a yellowish-white rectal SMT approximately 4 mm in diameter.The lesion did not show any irregularity of the vessels, irregularity of the surface pattern, or depression (Fig. 1). Endoscopic ultrasonography (EUS) (20 MHz, UM-DP20-25R;

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Section: Discussionmentioning

confidence: 99%

“…In the stomach, such micronests are known as endocrine cell micronests (ECM). However, only a few reports of ECMs have been reported in the colorectum (2,3,5,6), and their significance has not been clarified.…”

Section: Introductionmentioning

confidence: 99%

Single Rectal Neuroendocrine Tumor Associated with Multiple Endocrine Cell Micronests

et al. 2020

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“…The growth index, Ki67, of the ganglion cells and nerve fibers was <2%, and no mitotic figures or nuclear pleomorphism were observed, which suggested that DG exhibits an indolent or benign biological behavior. Malignant transformation of DG itself has not been reported, to the best of our knowledge; however, there are a number of case reports of DG coincident with adenocarcinoma (11–14), carcinoid tumor (15) or malignant peripheral nerve sheath tumor (1,16). Kanter et al (17) suggested that DG should be considered as a premalignant condition, but this association is controversial (13,18).…”

Section: Discussionmentioning

confidence: 95%

Synchronous diffuse ganglioneuromatosis and multiple schwannomas of the colon: A case report and literature review

Qiu

et al. 2015

Experimental and Therapeutic Medicine

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Diffuse ganglioneuromatosis (DG) of the gastrointestinal tract is a rare condition that is closely associated with neurofibromatosis type 1 and multiple endocrine neoplasia type 2B. The occurrence of DG with multiple schwannomas, which, of the GI tract, usually affect the stomach, is considerably more rare. The present study describes the case of a 54-year-old male with indolent DG, principally involving the small intestine and colon, associated with multiple schwannomas in the subserosa. The patient was treated with surgery. A brief overview of intestinal ganglioneuromatous lesions and the associated conditions is additionally presented.

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“…As the utility of screening colonoscopy has been increasing, more asymptomatic rectal NETs have been discovered, with most appearing as a single small lesion . The incidence of multiple NETs has been reported to range from 2% to 4.5%; however, multiple rectal NETs with numerous micronests are extremely rare . Treatment options for rectal NET depend on the size of the tumor, the depth of invasion, and the presence or absence of metastasis .…”

Section: Previous Reports Of Multiple Small Rectal Neuroendocrine Tumentioning

confidence: 99%

“…[1][2][3] The incidence of multiple NETs has been reported to range from 2% to 4.5%; however, multiple rectal NETs with numerous micronests are extremely rare. [4][5][6][7][8][9] Treatment options for rectal NET depend on the size of the tumor, the depth of invasion, and the presence or absence of metastasis. 5,10,11 Multicentricity of NET in the small intestine leads to a poor prognosis, but its effects on the prognosis of rectal NET are not fully understood.…”

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confidence: 99%