Multiple Recurrent Atypical Fibroxanthomas/Superficial Malignant Fibrous Histiocytomas of the Forehead Excised with Mohs Micrographic Surgery

Abstract

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Atypical fibroxanthoma: a series of 25 cases

“…4,[16][17][18] The mean time for metastasis to occur is 24 months. 19 A recurrence-free survival of 98.8% and 97.6% has been reported at 1 and 2 years respectively. 4 In the single patient with incomplete excision and radiotherapy, a relapse occurred within 6 months.…”

“…[6][7][8] The treatment of choice is the complete micrographic surgical excision of the tumour with a safety margin of about one cm. 4,11,[15][16][17][18][19][20][21] In patients without micrographic surgery, the relapse Atypical fibroxanthoma rate is about 12%. 4,[16][17][18] The mean time for metastasis to occur is 24 months.…”

The Evolving Conception and Management Challenges of Malignant Fibrous Histiocytoma

“…Several recent studies that have reported characteristic molecular and immunohistochemical features of these tumors, established specific cell lines, and described distinctive patterns of clinical behavior have challenged the notion of MFH as an ambiguous diagnostic endpoint. 10,11,[25][26][27][28][29][30][31][32][33][34] Although even recent dermatologic studies have referred to MFH arising in the soft tissues as a deeper or metastatic variant of AFX, it is now well established that these are different tumors, induced by separate stimuli and carrying unique genetic markers. 10,11,34 Still, similar patient, tumor, and immunohistochemical characteristics would seem to indicate a relationship between cutaneous MFH arising in photodamaged skin and AFX, although no studies have demonstrated tumor progression.…”