The transmission of natural gas is a key element of the Polish energy system. The published data of the Polish distribution system operators and the transmission system operator on the volume of gaseous fuel transmitted indicate a growing trend in the consumption of energy produced from natural gas. In connection with the energy transformation, switching energy generation sources from hard coal to natural gas in Poland, it is important for transmission operators to know the future demand for gaseous fuel. The aim of the article is to attempt to develop an econometric model related to the consumption of gaseous fuel by Polish entrepreneurs. The knowledge therein may be useful for making business decisions related to the possible expansion of the transmission system, and thus investing financial resources for this purpose. This knowledge will also provide quantitative information related to the interest in gaseous fuel among industrial consumers and the analysis of the trend of natural gas consumption in Poland in the aspect of energy transition. The intention of the publication was to determine the macroeconomic indicators that strongly affect natural gas consumption by the Polish industry and the quantitative growth of consumption depending on changes in these indicators. The results showed that the highest correlation of the growth of natural gas consumption is related to the production of chemistry, the chemical industry, and the power industry.