Multiple sclerosis patients have peripheral blood CD45RO+ B cells and increased intestinal permeability

Abstract

Increased intestinal permeability and the CD45RO isoform expression of the leukocyte common antigen on peripheral blood CD20+ B cells are found in Crohn's disease. Others have observed that multiple sclerosis (MS) patients may have an increased risk of coacquisition of Crohn's disease. The aim of this study was to identify an association between these diseases using peripheral blood CD45 isoform expression and intestinal permeability in MS. Lactulose/mannitol permeability and peripheral blood CD20+ B cell CD45RO expression were defined in healthy controls, MS patients, and patients coincidentally affected by MS and Crohn's or MS and ulcerative colitis (UC). Five of 20 MS patients had increased intestinal permeability, a finding not previously reported. High levels of CD45RO were found on circulating CD20+ B cells from patients with MS. This has not been reported previously in MS and is found in very few other conditions. Eight patients with coincident MS and Crohn's disease or MS and UC were studied. Coincident MS and UC patients expressed CD45RO on CD20+ B cells, a finding not identified in UC patients alone. A subgroup of MS patients has increased intestinal permeability. These patients express CD45RO CD20+ B cells, also found in Crohn's disease.

Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila

“…Although the relationship between intestinal homeostasis and mammalian lifespan is less well understood, several age-related changes in the intestinal epithelium of rodents have been reported (9), including intestinal barrier dysfunction (31). The importance of the gut epithelium in human health is demonstrated by the growing number of disorders that have been linked to defects in intestinal barrier function, including intestinal or extraintestinal inflammatory disorders (32,33), multiple sclerosis (34), chronic heart failure (35), cancer (36,37), and Parkinson's disease (38). In terms of mortality in humans, intestinal barrier dysfunction is reportedly common in critically ill patients and linked to development of the multiple organ dysfunction syndrome (39)(40)(41).…”

The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseases

“…Changes in gut barrier function, i.e., increased intestinal permeability in patients, as well as in their relatives, has been reported. 99 Viruses and bacteria have been suggested to participate in the pathogenesis of multiple sclerosis. Based on morphological and immunological findings in the brains of patients, attention has recently been given to the common infection with Epstein-Barr virus.…”

The Role of Intestinal Barrier Function in Early Life in the Development of Colitis

“…There is increasing evidence to suggest intestinal barrier dysfunction results in immune responses that can target any organ or tissue in genetically predisposed individuals (Fasano & Shea-Donohue, 2005;Fasano, 2011), such as the skeletal system (ankylosing spondylitis, rheumatoid arthritis: Edwards, 2008), pancreas (type 1 diabetes: (Carratù et al, 1999), kidney (IgA nephropathy: Davin et al, 1988), liver (nonalcoholic steatohepatitis: Wigg et al, 2001), and brain (multiple sclerosis; Yacyshyn et al, 1996). Barrier dysfunction can also result in an aberrant or exaggerated inflammatory response to the intestinal microbiota.…”