Multiple spatially resolved reflection spectroscopy to monitor cutaneous carotenoids during supplementation of fruit and vegetable extracts in vivo

Meinke, Martina C.; Lohan, Silke B.; Köcher, W.; Magnussen, Björn; Darvin, Maxim E.; Lademann, J.

doi:10.1111/srt.12356

Cited by 18 publications

(13 citation statements)

References 19 publications

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“…This sensor is commercially available under the tradename biozoom (model Biozoom Portable, Kassel, Germany). It uses several differently positioned light sources and light detectors, exhibiting different distances between light source and detector and different angles for irradiation and detection, and has been described in detail elsewhere [ 23 , 46 ]. Briefly, the LED light sources cover a spectral range from approximately 350 nm to 1000 nm in wavelength in 16 steps, providing 118 light emitters.…”

Section: Methodsmentioning

confidence: 99%

“…The second carotenoid sensor was a CaroLED sensor (Laser-und Medizin-Technologie Berlin, LMTB, Germany). The underlying measuring principle of CaroLED is based on SRRS, and was recently described by Meinke et al [ 46 ]. Briefly, five light emitting diodes (LED) of different wavelengths in the visible and near infrared region illuminate the skin through a measurement window.…”

Section: Methodsmentioning

confidence: 99%

“…The hypothesis is that systemically administered carotenoids will increase the collagen I synthesis or at least prevent its decrease, which usually occurs due to oxidative stress during our life, and results in skin aging. In the presented in vivo study, two different cutaneous carotenoid sensors, which were recently developed based on spatially resolved reflectance spectroscopy (SRRS), were applied to monitor the skin carotenoids noninvasively [ 46 ]. To increase the skin carotenoids, a vegetable curly kale extract rich in carotenoids, in comparison to a placebo, was systemically administered over a time period of 10 months.…”

Section: Introductionmentioning

confidence: 99%

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Influences of Orally Taken Carotenoid-Rich Curly Kale Extract on Collagen I/Elastin Index of the Skin

et al. 2017

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Two differently designed, spatially resolved reflectance spectroscopy-based scanners and two-photon tomography were used for noninvasive in vivo determination of cutaneous carotenoids, and collagen I/elastin aging index of dermis, respectively, in the skin of 29 healthy female volunteers between 40 and 56 years of age. The volunteers received a supplement in the form of a carotenoid-rich natural curly kale extract containing 1650 µg of carotenoids in total (three capsules of 550 µg), once a day. Measurements were taken before, after 5 months and after 10 months of daily supplementation. The results showed significantly increased values for the cutaneous carotenoids and the collagen I/elastin aging index of dermis 5 and 10 months after the beginning of the study. The obtained results show that a natural carotenoid-rich extract could prevent the aging-related collagen I degradation in the dermis and improve the extracellular matrix.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Influences of Orally Taken Carotenoid-Rich Curly Kale Extract on Collagen I/Elastin Index of the Skin

et al. 2017

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“…The discovery of the acid mantle of the skin and its importance was confirmed with a gas chain bell electrode [46]. Potentiometric measurements and glass electrodes were then subsequently developed and validated [47]. Gradual changes in the skins surface pH as we age have been reported [48,49].…”

Section: Skin Surface Phmentioning

confidence: 98%

An updated review of clinical methods in the assessment of ageing skin – New perspectives and evaluation for claims support

Bielfeldt¹,

Springmann²,

Seise³

et al. 2018

Intern J of Cosmetic Sci

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With the advancement of skin research, today's consumer has increased access to an informed understanding of ageing skin and its appendages, together with a plethora of targeted products to meet such needs. In recent years, increased legislative demands for quality evidential claims support have led not only to the development and validation of clinical methods to measure and quantify ageing skin, but also a clearer understanding of the skin ageing process-especially the impact of both its internal and external environments-as well as a tougher stance on clearly unjustifiable claims. Traditional testing methods used to research and evaluate anti-ageing products claim to employ sophisticated instruments. Today, however, since the term anti-ageing can be considered a misnomer, intelligent use of combined more advanced clinical methods has enabled the development of technologically improved consumer products providing enhanced efficacy and targeted performance. Non-invasive methods for the assessment and quantification of the causes of ageing skin provide tools to the clinical researcher as defined by key clinically observed ageing parameters. Where evidence requires additional support, a number of clinical procedures evaluating ageing skin and hair products are combined with invasive procedures, thus enabling an added value to product claims. As discussed herein, given the enhanced understanding of ageing, we provide an update to our previous reviews of clinical methods used in the assessment of skin ageing, to include the wider aspects of environmental exposure; skin pigmentation; microbiome disturbance; surface topography; colour, radiance, and pH; and structural integrity-all requiring a disciplined approach to their use in dermatological investigations and product claims evidence.

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“…Resonance Raman spectroscopy was used for the noninvasive quantitative assessment of the concentration of cutaneous carotenoids, which serve as marker substances for the antioxidant status of the F I G U R E 1 Microscopic image of the polyester 3D spacer fabric. The scale bar represents 1 mm epidermis, [35][36][37] on six subjects. Thereby, the measurement volume in the skin was excited at 488 nm, leading to a resonant excitation of carbon double bond vibrations to be detected at 1525 cm -1 that relates to the carotenoid concentration.…”

Section: Cutaneous Carotenoid Concentrationmentioning

confidence: 99%

Influence of polyester spacer fabric, cotton, chloroprene rubber, and silicone on microclimatic and morphologic physiologic skin parameters in vivo

Jung

Schleusener

Knorr

et al. 2019

Skin Research and Technology

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Background Skin diseases can develop upon disadvantageous microclimate in relation to skin contact with textiles of supporting devices. Increased temperature, moisture, mechanical fracture, pressure, and inflammatory processes often occur mutually and enhance each other in their adverse effects. Therefore, the early prevention of skin irritations by improvement of microclimatic properties of skin in contact with supporting devices is important. Materials and Methods In this study, the microclimate under occlusion with polyester, cotton, chloroprene rubber, and silicone textiles, used for supporting devices, was analyzed by determining several characteristic physiologic skin parameters in vivo, including temperature, moisture, and transepidermal water loss (TEWL). This is achieved by comparing a miniaturized in vivo detection device with several established optical and sensory methods in vivo. Results A highly significant TEWL decrease was found after polyester, chloroprene rubber, and silicone application. The application of all materials showed highly significant decrease in skin surface temperature, with chloroprene rubber showing the lowest. Similarly, all materials showed highly significant increase in relative moisture, where the highest increase was found for chloroprene rubber and silicone and the lowest increase for cotton. The cutaneous carotenoid concentration of chloroprene rubber, silicone, and polyester decreased. A manipulation of the surface structure of the stratum corneum was recognized for all materials except for cotton by laser scanning microscopy. Conclusion The skin parameters temperature, relative moisture, antioxidant status, and TEWL can effectively characterize the microclimatic environment during occlusion with medical supporting materials. These parameters could potentially be used to develop standardized testing procedures for material evaluation.

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Multiple spatially resolved reflection spectroscopy to monitor cutaneous carotenoids during supplementation of fruit and vegetable extracts in vivo

Abstract: The results illustrate that a biofeedback by measuring the skin carotenoids could improve the lifestyle of young adults and that a regular consumption of fruit and vegetables directly or as a drink can increase the concentration of cutaneous carotenoids significantly.

Cited by 18 publications

References 19 publications

Influences of Orally Taken Carotenoid-Rich Curly Kale Extract on Collagen I/Elastin Index of the Skin

Influences of Orally Taken Carotenoid-Rich Curly Kale Extract on Collagen I/Elastin Index of the Skin

An updated review of clinical methods in the assessment of ageing skin – New perspectives and evaluation for claims support

Influence of polyester spacer fabric, cotton, chloroprene rubber, and silicone on microclimatic and morphologic physiologic skin parameters in vivo

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