Multiple Species Comparison of Cardiac Troponin T and Dystrophin: Unravelling the DNA behind Dilated Cardiomyopathy

England, Jennifer; Loughna, Siobhan

doi:10.3390/jcdd4030008

Cited by 6 publications

(9 citation statements)

References 149 publications

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“…Exon 8 skipping in affected individuals has been a suggested link in cardiac troponin T and it has also been indicated that wild turkeys have the similarly low molecular weight as exon 8 is spliced out [87]. This is also notable as humans carrying specific mutations in troponin T are also affected by cardiomyopathies [88]. Over 90 mutations have been described in the troponins in humans to date which result in heart disorders including hypertrophic, dilated and restrictive cardiomyopathy in addition to left ventricular non-compaction.…”

Section: Cardiomyopathiesmentioning

confidence: 99%

“…Over 90 mutations have been described in the troponins in humans to date which result in heart disorders including hypertrophic, dilated and restrictive cardiomyopathy in addition to left ventricular non-compaction. It has also been highlighted that despite variable regions of troponin, there are some areas which are highly conserved between species including most mammals, turkeys and chickens [88]. The areas containing the most causative mutations in humans are the T1 terminal and the C-terminal and cardiac troponin T, therefore these regions make excellent candidates for future studies, not only in turkeys but in other birds too.…”

Section: Cardiomyopathiesmentioning

confidence: 99%

See 1 more Smart Citation

Avian Cardiovascular Disease Characteristics, Causes and Genomics

Kubale¹,

Merry²,

Miller³

et al. 2018

Application of Genetics and Genomics in Poultry Science

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Cardiovascular disease is common in avian species and increasing commercial economic losses and demand for healthcare in the household/smallholding veterinary sector has resulted in increased research into these disorders. This in turn has highlighted the importance of breeding, genetic testing and possibilities for future prognostic and diagnostic testing. Research into avian cardiovascular genetics has rapidly accelerated. Previously much work was undertaken in mammals with information extrapolated and transferred to birds. Birds have also been used to model cardiovascular disease and therefore knowledge has become enriched due to this endeavour. Increasingly, the avian genome is being analysed in its own right. This work is assisted by the growing number of avian genomes being published. In 2015, Nature published news on the 'Bird 10K' project, which aims to sequence 10,500 extant bird species. By 2018, the Avian Genomes Consortium had published the sequences of 45 species/34 orders. This review investigates a range of avian cardiovascular disorders in order to highlight their pathologies, epidemiology and genetics in addition to avian models of heart disease. With the availability of more reference genomes, increases in the number and magnitude of avian studies and more advanced technologies, the genetics behind avian cardiovascular disorders is being unravelled.

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Section: Cardiomyopathiesmentioning

confidence: 99%

Section: Cardiomyopathiesmentioning

confidence: 99%

Avian Cardiovascular Disease Characteristics, Causes and Genomics

Kubale¹,

Merry²,

Miller³

et al. 2018

Application of Genetics and Genomics in Poultry Science

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show abstract

“…It is one of several different types of "cardiomyopathy, " heart disorders that are seen in humans and animals. Common types of cardiomyopathy are called: (1) hypertrophy; (2) dilated; and (3) restrictive [1].…”

Section: How Do Hearts Get Broken?mentioning

confidence: 99%

Mending a Broken Heart—The Genetics of Heart Disease

Clark¹,

Alibhai²

2018

Front. Young Minds

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Heart disease is a major cause of health problems worldwide. There are many different types of heart disease, but one that is fairly common and can have lots of negative side effects is called cardiomyopathy. We know that humans and many mammals, including dogs, get cardiomyopathy. In dilated cardiomyopathy the heart changes shape and often the electrical signals within the heart change. Because of these changes, the heart is not able to pump blood around the body very well, which means that oxygen and nutrients are not delivered to the body at the optimal levels. This can affect day-today life, and it can also cause early death. Understanding cardiomyopathy and finding the mutations in genes that cause it are essential, as this information can help us to diagnose, treat, and prevent this heart disorder. We can try to mend the broken hearts that do not work properly. In dogs with cardiomyopathy, we have discovered genetic mutations and found links between these changes in the dogs' hearts. THE HEART The heart pumps blood to the lungs where oxygen goes into the blood, it is then pumped back to the heart and then this blood gets pumped around REVIEWED BY:

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“…Given the rapid development of and stress exposure in broilers and the sudden death syndrome associated with cardiovascular diseases due to lubrication in internal organs, broilers breeding facilities are associated with high mortality. Studies have shown that the mortality rate is doubled in birds fed high-protein diets (Breeding et al, 1994;England et al, 2017). Cardiomyopathies are diseases of the heart muscle that result from heart failure and cause cardiac dysfunction.…”

Section: Introductionmentioning

confidence: 99%

“…Cardiomyopathies are associated with decreased diastolic volume especially in the ventricles, a dilated atrium, limited ventricular filling and rarely, ventricular myocardial fibrosis. In this case, fat accumulation is caused by the prevention of electrical conduction and arrhythmias (Maron et al, 2006;Wieczorek et al, 2008;Wexler et al, 2009;England et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Effects of Varying Essential Oil Mixture Concentrations Applied Underconditions of Different Temperature Stress on Cardiac Markers and Other Blood Parameters

Bayraktar

Tekce

2019

Braz. J. Poult. Sci.

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Cardiac troponin (cTnI) and erythrocyte distribution width (RDW) have been used as specific markers for the evaluation of cardiac arrhythmias and myocardial diseases. In this experimental study, we aimed to determine the dose-dependent administration of an Essential OilMixture (EOM) (Eucalyptus globulusLabill, Thymus vulgaris, Cymbopogon nardus, and Syzygiumaromaticum) on the serum erythrocyte indices and myocardial damage. We used 400 male, oneday-old, Ross-308 chicks. Each group ((n=8) (22°C Control (C), C+250 mL/1,000 L, C+500 mL/1,000 L, C+750 mL/1,000 L), 36°C (stress control (SC), SC+250 mL/1,000 L, SC+500 mL/1,000 L, SC+750 mL/1,000 L) was further divided into eight groups with 50 animals. Each group of 50 chicks was further subdivided into five groups with 10 animals in each compartment. The results showed that the WBC, RBC, HGB, HCT, RDW-SD, RDW-CV, and Lymphocyte decreased in groups without exposure to temperature stress (22ºC) compared to the 22ºC control group; whereas, CnTnI, MCHC, NEUT, and IG (p<0.05) increased compared to the control group. In groups exposed to temperature stress (36ºC), the WBC, HGB, HCT, RDW-SD, and Lymphocyte decreased compared to the control group, but MCH, MCHC, NEUT, and IG increased compared to the control. However, cTnI, CK, creatinine, RBC, and RDW had no effect on CD, MONO, EO, and BASO (p<0.05). EOM mixture had no effect on hematological and biochemical parameters.

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Multiple Species Comparison of Cardiac Troponin T and Dystrophin: Unravelling the DNA behind Dilated Cardiomyopathy

Cited by 6 publications

References 149 publications

Avian Cardiovascular Disease Characteristics, Causes and Genomics

Avian Cardiovascular Disease Characteristics, Causes and Genomics

Mending a Broken Heart—The Genetics of Heart Disease

Effects of Varying Essential Oil Mixture Concentrations Applied Underconditions of Different Temperature Stress on Cardiac Markers and Other Blood Parameters

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