Multiple Stimulus Response 2D Framework Constructed by a Flexible Cyclotriphosphazene-Derived Carboxylic Acid Linker: Synthesis, Characterization, and Fluorescence Sensing to Phenolic Pollutants and Small-Molecule Drugs

Abstract

Hexachlorocyclotriphosphazene is one of the most representative phosphazene compounds which have been proved to have broad application prospects in many fields. However, it is an emerging research perspective to combine cyclotriphosphazene-derived polycarboxylic acid compounds with lanthanides for the construction of Tb-DPCP metal−organic f r a m e w o r k ( M O F ) m a t e r i a l s . H e r e i n , a T b -D P 1), was successfully prepared via the reaction of H 12 HDPCP [hexa(4-carboxyphenoxy) cyclotriphosphazene] and Tb(NO 3 ) 3 •6H 2 O under the solvothermal condition. Through fluorescence sensing experiments, it was found that both nitrophenols and chlorophenols could cause the fluorescence quenching of compound 1. At the same time, the compound also exhibited nice trace detection ability for small-molecule drugs (moxifloxacin hydrochloride, balsalazide disodium, and colchicine); the limits of detection were all lower than 0.2 μM. These experimental results fully demonstrated the potential application value of 1 as a multifunctional fluorescent sensor.

Metal–Organic Framework-Based Fluorescent Sensors for the Detection of Pharmaceutically Active Compounds

“…Like every drug, several side effects (gastrointestinal distress, bone marrow suppression, muscle weakness, disturbances in kidney and liver functions, etc.) are observed by the excessive use of these drugs …”

“…BAL is used to cure ulcerative colitis, which is a kind of inflammatory bowel disease that mostly affects the rectum and colon. 136 On the other hand, COL is principally used to treat and prevent gout attacks, which is a kind of inflammatory arthritis produced by the accumulation of uric acid crystals in the joints. 136 Additionally, it is effective for the treatment of some other inflammatory diseases as well as familiar Mediterranean fever.…”

“…136 On the other hand, COL is principally used to treat and prevent gout attacks, which is a kind of inflammatory arthritis produced by the accumulation of uric acid crystals in the joints. 136 Additionally, it is effective for the treatment of some other inflammatory diseases as well as familiar Mediterranean fever. BAL treats ulcerative colitis.…”

“…are observed by the excessive use of these drugs. 136 A 2D Tb(III)-based MOF (Tb-DPCP) was synthesized by Wang et al for the sensing of BAL and COL. 136 The PL intensity of Tb-DPCP was significantly quenched after adding these two drugs. The measured K sv and LOD values of BAL and COL were 1.86 × 10 5 and 2.04 × 10 5 M −1 , and 0.13 and 0.12 μM, respectively (Figure 14d).…”

Dual-Emitting Mixed-Lanthanide Metal–Organic Framework for Ratiometric and Quantitative Visual Detection of 2,6-Pyridine Dicarboxylic Acid

“…In recent years, various DPA detection methods have been reported, including electrochemistry, high-pressure liquid chromatography, surface-enhanced Raman spectroscopy, and so on. − However, shortcomings such as expensive equipment, time consumption, and complicated sample preparation limit their application. Compared with these methods, fluorescence sensing has attracted enormous interest due to its easy operation, high sensitivity, and fast response. − Previous studies have shown that dual-emitting probes perform better in chemical sensing through self-calibration compared to single-emitting systems. , Some interesting ratiometric fluorescent probes have been reported for DPA detection.…”