Index modulation-aided orthogonal frequency-division multiplexing(IM-OFDM) is a promising modulation technique to achieve high spectral and energy efficiency. In this chapter, the conventional optical OFDM schemes are firstly reviewed, followed by the principles of IM-OFDM. The application of IM-OFDM in visible light communication (VLC) systems is introduced, and its performance is compared with conventional optical OFDM, which verifies its superiority. Finally, the challenges and opportunities of IM-OFDM are discussed for the VLC applications.