Multiple (Subcutaneous) Angiolipomas

Belcher, Richard W.

doi:10.1001/archderm.1974.01630100043010

Cited by 21 publications

(6 citation statements)

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“…Multiple subcutaneous angiolipomas are foci of benign, noninvasive neoplasia of lipomatous and vascular tissue 5,6 . Howard and Helwig 5 studied 288 cases of angiolipomas in 248 patients and determined that the average age of onset was 17 years.…”

Section: Discussionmentioning

confidence: 99%

“…Minimal mitotic activity and well‐differentiated cellular components are the rule 5 . Varying gradations of cellularity, endothelial proliferation, and intercapillary fibrous and collagenous material can be seen 5,6 . Fibrous septa radiate from the outer capsule, and capillary growth tends to occur peripherally 1,5,6,11 .…”

Section: Discussionmentioning

confidence: 99%

“…Small, thin‐walled vessels with prominent pericytic proliferation and a complex branching pattern characterize the vascular component 3,11 . Intravascular fibrin thrombi are commonly observed, as are mast cells 1,3,5–7,11 . Hunt et al 11 .…”

Section: Discussionmentioning

confidence: 99%

“…5 Varying gradations of cellularity, endothelial proliferation, and intercapillary fibrous and collagenous material can be seen. 5,6 Fibrous septa radiate from the outer capsule, and capillary growth tends to occur peripherally. 1,5,6,11 Small, thin-walled vessels with prominent pericytic proliferation and a complex branching pattern characterize the vascular component.…”

Section: Discussionmentioning

confidence: 99%

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Multiple subcutaneous angiolipomas associated with new‐onset diabetes mellitus

2002

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A 44‐year‐old Hispanic man, with a past medical history of diabetes mellitus type 2 and cerebrovascular accident, presented to the Mount Sinai Department of Dermatology with sudden, fast‐growing nodules over both of his shins. Approximately 2 months before the appearance of the nodules, the patient was diagnosed with diabetes mellitus type 2 with hemoglobin A1c (HbA1c) of 8.5%. The patient was taking metformin orally, 500 mg three times daily, at the time of presentation. Six nodules appeared over a period of days. They caused a burning, throbbing pain upon ambulation. Over a period of 6 months, the lumps decreased in size, and two totally disappeared. The resolution of the nodules coincided with the control of the patient's diabetes, as demonstrated by HbA1c of 5.5%. The patient denied trauma to the sites of the nodules. The patient denied any associated purpura or ecchymoses over the nodules. The past medical history was significant for a stroke with residual right hemiparesis at 42 years of age. The family history was negative for similar lesions, but an aunt did have diabetes mellitus type 2. The patient denied alcohol use, smoking, or intravenous drug use. Physical examination was positive for six soft, tender, freely mobile, symmetrical, well‐demarcated, round masses, 1–2 cm in diameter and skin colored, over the anterior aspects of both legs. The patient was obese (body mass index, 38.5). Laboratory tests (barring the initially elevated HbA1c) were normal. One lesion was excised. Histopathology revealed features typical of an angiolipoma (see Fig. 1a,b). A karyotype of the angiolipoma was not performed. 1 (a) Prominent vessels filled with fibrin thrombi at the periphery of mature fat lobules. (b) At higher magnification Because excision of one angiolipoma produced scarring with a poor cosmetic result, intralesional triamcinolone, 5 mg/mL, was tried without success.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Multiple subcutaneous angiolipomas associated with new‐onset diabetes mellitus

2002

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“…A ngiolipoma is an encapsulated subcutaneous nodule that is found on the trunk or extremities 1–5 . Recently, liposuction surgery has been widely accepted for body contouring as well as other noncosmetic applications including lipoma and angiolipomatosis 6–21 .…”

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confidence: 99%