Multiple (subcutaneous) angiolipomas. Clinical, pathologic, and pharmacologic studies

Belcher, Richard W.

doi:10.1001/archderm.110.4.583

Cited by 15 publications

(11 citation statements)

References 4 publications

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“…More than 2/3rd angolipomas are multiple [6]. Belcher et al [7] reported a patient who developed 204 angiolipomas over a 15-year period. Single cases of angiolipoma in the maxillary sinus [8], parotid [9] and temporalis muscle [10] have been described in the literature.…”

Section: Discussionmentioning

confidence: 99%

Angiolipoma Larynx: A Case Report

Rai

Verma²

2011

Indian J Otolaryngol Head Neck Surg

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We report an extremely rare case of angiolipoma larynx Case report and a review of the world literature concerning angiolipoma are presented. A case of tumour of the larynx in a 72-year-old male who underwent excision by a lateral pharyngotomy approach. Histopathological diagnosis was angiolipoma. 19 cases of angiolipoma have been reported from head and neck region, none from the larynx. To our knowledge this is the first report in the world literature of angiolipoma larynx.

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Section: Discussionmentioning

confidence: 99%

Angiolipoma Larynx: A Case Report

Rai

Verma²

2011

Indian J Otolaryngol Head Neck Surg

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“…Only a few cases have been reported in the literature [3,4]. There is no relationship to adiposis dolorosa (Dercum's disease), with painful diffuse adipose tissue deposits principally in the lower legs of elderly obese women, often associated with psychological phenomena [5,7].…”

Section: Discussionmentioning

confidence: 99%

“…They frequently occur as solitary subcutaneous nodules [4] located close to the dermis in young adults [8]. Characteristically these lipomatous tumors are tender on palpation, and the diameter of these masses rarely exceeds 2 cm [1].…”

Section: Introductionmentioning

confidence: 99%

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Painful angiolipomatosis: evaluation of the extended subcutaneous lipectomy and the immunohistochemical and histological analysis compared to other benign lipomatous tumors

et al. 2003

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Angiolipomas are benign subcutaneous tumors that usually develop in young adults. Few reports describe cases with more than 200 of these extremely painful tumors found in a single patient. We report two cases of adult men suffering from painful angiolipomas with a similar history. Oral salbutamol and lidocaine infusion did not help, and analgesics gave only slight relief. Both patients retired from work early. The two patients were treated by subcutaneous lipectomy; 574 angiolipomas were removed in one case and 215 in the other. Painless lipomas of ten patients (10), painless angiolipomas in two patients (10), and ten painful angiolipomas of each of the described patients were analyzed histologically and by immunohistochemistry (S-100, CD34). We compared the quantity of vessels, nerves, and thrombi. Postoperative complications were hematoma (3/11) and seroma (5/11) formations. Pain relief and low incidence of recurrence were achieved. The highest concentration of vessels was found in angiolipomas (+++), with no difference between painful and painless tumors, less in ordinary lipomas (−/+). In angiolipomas the vessel location was more typically in the subcapsular region. Nerves were found to a slight degree in the painful angiolipomas (−/+), but none were found in the painless angiolipomas and lipomas (−). The quantity of fibrin thrombi was much higher in painful angiolipomas (++) than in painless angiolipomas (−/+). Extended subcutaneous lipectomy is a reliable method for treating severe forms of painful angiolipomatosis. Advantages of the technique are a reduced number of operations, pain relief, and a lower rate of recurrence at the operated sites. The only obvious signs in painful angiolipomas (which rarely appear in painless benign lipomatous tumors) are vascularity and thrombi formation in the vessels located close to the capsule. This pain could be related to ischemia. Treatment options should include special prophylaxis against thrombus formation.Painful angiolipomatosis: evaluation of the extended subcutaneous lipectomy and the immunohistochemical and histological analysis compared to other benign lipomatous tumors

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“…Nerves within angiolipomas or their capsules have not been demonstrated in the majority of tumors examined with Bodian stain^.^^,^^ In addition, myelinated nerves in the connective tissue beneath painful angiolipomas were not compressed by the tumor. 35 In another study, occasional compression of nerve fibers accompanying blood vessels was reported in encapsulated painful angiolipomas by Lin and Lin.36 In a case of a tender infiltrating angiolipoma, the angiomatous component was seen infiltrating the epi-and perineurium of nerve fibers. 36 Intratumoral injections of mast cell degranulators and histamine did not produce pain in one study, so that mast cells were not thought to play a part in pain p r o d u c t i~n .~~ Treatment for angiolipomas is surgical excision.…”

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confidence: 92%