Multiple Trajectories of Successful Aging of Older and Younger Cohorts

Hsu, Hui‐Chun; Jones, Bobby

doi:10.1093/geront/gns005

Cited by 116 publications

(85 citation statements)

References 59 publications

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“…Whılst the trajectory of aging can differ among older people (1), there is general agreement that aging is associated with an accumulation of cellular damage (2). The pathophysiological changes associated with aging can lead to mitochondrial dysfunction, failure of tissue repair mechanisms, accelerated cellular senescence, in addition to a reduction in tissue homeostasis, which may increase the risk of organ failure and mortality (3).…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress and frailty: A systematic review and synthesis of the best evidence

et al. 2017

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Highlights There is a lack of clarity around the relationship between oxidative stress and frailty.  Our review provides some cross sectional evidence of increased oxidative stress among frail older people.  There is some preliminary evidence of lower anti-oxidant parameters (vitamin C, E, α-tocopherol, biological anti-oxidant potential, total thiol levels) in frailty. ABSTRACT (250/250)Objective: Oxidative stress (OS) is associated with accelerated aging. Previous studies have suggested a possible relationship between OS and frailty but this association remains unclear.We conducted a systematic review to investigate potential interactions between OS and frailty.Methods: A systematic literature search of original reports providing data on 'OS and antioxidant' parameters and frailty was carried out across major electronic databases from inception until May 2016. Cross-sectional/case control and longitudinal studies reporting data on the association between frailty and anti-oxidants-OS biomarkers were considered for inclusion. Results were summarized with a best-evidence based synthesis.Results: From 1,856 hits, 8 studies (cross-sectional/case control) were included (N=6,349; mean age of 75±12 years; 56.4% females). Overall, there were 588 (=9.3%) frail, 3,036 prefrail (=47.8%), 40 (=0.6%) pre-frail/robust, and 2,685 (=42.3%) robust subjects. Six crosssectional/case control studies demonstrated that frailty was associated with an increase in peripheral OS biomarkers including lipoprotein phospholipase A2 (studies=1), isoprostanes (studies=2), Malonaldehyde (studies=2), 8-hydroxy-20-deoxyguanosine (studies=2), derivate of reactive oxygen metabolites (studies=2), oxidized Glutathione/ Glutathione (studies=1), 4-hydroxy-2,3-nonenal (studies=1), and protein carbonylation levels (study=1). In addition, preliminary evidence points to lower anti-oxidant parameters (vitamin C, E, α-tocopherol, biological anti-oxidant potential, total thiol levels) in frailty. Conclusion:Frailty and pre-frailty appear to be associated with higher OS and possibly lower anti-oxidant parameters. However, due to the cross sectional design, it is not possible to disentangle the directionality of the relationships observed. Thus, future high quality and in particular longitudinal research is required to confirm/refute these relationships and to further elucidate pathophysiological mechanisms.

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Section: Introductionmentioning

confidence: 99%

Oxidative stress and frailty: A systematic review and synthesis of the best evidence

et al. 2017

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“…To date, the dynamic parallel development of physical and mental health in old age remains relatively unexplored for at least two reasons. First, studies aimed at the description of multidimensional end-of-life health trajectories usually include a relatively large number of health dimensions and rely on growth curve and group-based trajectory models (e.g., Hsu and Jones 2012;Wickrama et al 2013). This approach provides a useful general overview, but is limited to revealing complex nonlinear associations between specific health dimensions as they unfold over time.…”

Section: Introductionmentioning

confidence: 99%

Pathways to death: The co-occurrence of physical and mental health in the last years of life

Raab¹,

Fasang²,

Heß³

2018

DemRes

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“…Moreover, with more availability of longitudinal data, recent studies began exploring trajectories of successful ageing (e.g. Hsu and Jone 2012;Tang 2014). …”

Section: Introductionmentioning

confidence: 99%

Prevalence and correlates of successful ageing: a comparative study between China and South Korea

2014

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Successful ageing is often defined as a later life with less disease and disease-related disability, high level of cognitive and physical functions, and an active life style. Few studies have compared successful ageing across different societies in a non-Western social context. This study aims to compare prevalence and correlates of successful ageing between China and South Korea. The data come from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) and the Korean Longitudinal Study of Ageing (KLoSA). A total of 19,346 community-dwelling elders over 65 years were included, 15,191 from China and 4,155 from Korea. A multidimensional construct of successful ageing was used, with the criteria of no major comorbidity, being free of disability, good mental health, engaging in social or productive activity, and satisfaction on life. Correlates of successful ageing included demographics (gender, age, and rural/urban residence), socioeconomic features (financial status, education, and spouse accompany), and health behaviours (smoking, alcoholdrinking, and exercising). The results showed that 18.6 % of the older adults in China was successful agers, which was less than 25.2 % in Korea. When gender and age were adjusted, older adults were 51 % less likely to be successful agers in China than Korea (p \ 0.001).

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Multiple Trajectories of Successful Aging of Older and Younger Cohorts

Abstract: This study provides empirical findings of the heterogeneity of successful aging trajectories in multidimensional indicators.

Cited by 116 publications

References 59 publications

Oxidative stress and frailty: A systematic review and synthesis of the best evidence

Oxidative stress and frailty: A systematic review and synthesis of the best evidence

Pathways to death: The co-occurrence of physical and mental health in the last years of life

Prevalence and correlates of successful ageing: a comparative study between China and South Korea

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