Multiple uses of Essential Oil and By-Products from Various Parts of the Yakushima Native Cedar (Cryptomeria Japonica)

Nakagawa, Toshinori; Zhu, Qing; Ishikawa, Hiroya; Ohnuki, Koichiro; Kakino, Kenichi; Horiuchi, Naoya; Shinotsuka, Hiroaki; Naito, Terumi; Matsumoto, Tsuyoshi; Minamisawa, Noriko; Yatagai, Mitsuyoshi

doi:10.1080/02773813.2015.1057648

Cited by 22 publications

(8 citation statements)

References 20 publications

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“…The antimelanogenic properties of EO from Pomelo Peel have demonstrated in B16 cells where it blocked the synthesis pathway of melanin through the decrease of expression and activity of intracellular tyrosinase, without affecting cell viability and morphology [68]. Moreover, EOs from Cryptomeria japonica (Yakushima native cedar), Syzygium aromaticum (Clove oil) and Cinnamomum zeylanicum demonstrated antimelanogenesis activity in the same experimental model [33,81,245]. The last two EOs contained a high level of eugenol, which was also found to inhibit tyrosinase and melanogenesis in the same model [81].…”

Section: Antimelanogenic Activitymentioning

confidence: 96%

Essential Oils and Their Main Chemical Components: The Past 20 Years of Preclinical Studies in Melanoma

Martile

Garzoli

Ragno

et al. 2020

Cancers

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The last two decades have seen the development of effective therapies, which have saved the lives of a large number of melanoma patients. However, therapeutic options are still limited for patients without BRAF mutations or in relapse from current treatments, and severe side effects often occur during therapy. Thus, additional insights to improve treatment efficacy with the aim to decrease the likelihood of chemoresistance, as well as reducing side effects of current therapies, are required. Natural products offer great opportunities for the discovery of antineoplastic drugs, and still represent a useful source of novel molecules. Among them, essential oils, representing the volatile fraction of aromatic plants, are always being actively investigated by several research groups and show promising biological activities for their use as complementary or alternative medicine for several diseases, including cancer. In this review, we focused on studies reporting the mechanism through which essential oils exert antitumor action in preclinical wild type or mutant BRAF melanoma models. We also discussed the latest use of essential oils in improving cancer patients’ quality of life. As evidenced by the many studies listed in this review, through their effect on apoptosis and tumor progression-associated properties, essential oils can therefore be considered as potential natural pharmaceutical resources for cancer management.

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Section: Antimelanogenic Activitymentioning

confidence: 96%

Essential Oils and Their Main Chemical Components: The Past 20 Years of Preclinical Studies in Melanoma

Martile

Garzoli

Ragno

et al. 2020

Cancers

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“…Cryptomeria japonica, commonly known as Japanese Sugi pine, is a monotypic genus of pinophyta indigenous to Japan. They are often planted around farms to create shelter lines, which increase pasture productivity by creating favorable microclimates for crop and stock [6]. While Sugi essential oil possess both antibacterial and antifungal properties, there are limited applications that take advantage of its bioactive properties [7,8].…”

Section: Introductionmentioning

confidence: 99%

Leptospermum scoparium (Mānuka) and Cryptomeria japonica (Sugi) Leaf Essential Oil Seasonal Chemical Variation and Their Effect on Antimicrobial Activity

Bang¹,

Lewis²,

Villas‐Bôas³

2020

Preprint

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This study evaluated the antimicrobial activity of Leptospermum scoparium (Mānuka) and Cryptomeria japonica (Sugi) essential oils and assessed the effect of seasonal chemical variation on the oils’ antimicrobial efficacies. Plate based assays were conducted to elucidate the oils’ spectrum of in vitro antimicrobial activity and to determine the oils’ minimum inhibitory concentrations (MIC) as a measure of antimicrobial efficacy. Gas chromatography – mass spectrometry was adopted to chemically profile oils distilled in different seasons. The resultant compositional information in conjunction with MIC data was used to evaluate the effect of seasonal variation on the oils’ antimicrobial efficacy. Both Mānuka and Sugi essential oils were active against all classes of target microorganisms. However, limited activity was observed against Gram-negative bacteria. The oils displayed consistent chemotypic characteristics regardless of the time of distillation. Nonetheless, there were quantitative differences in compound abundance in both essential oils. Significant differences in the MIC of Sugi essential oil was observed against target microorganisms as a result of seasonal variation in constituent abundances while Mānuka essential oil’s antimicrobial efficacy was unaffected. This study demonstrates that seasonal chemical variation is an important quality assurance parameter to consider for future application of essential oils as antimicrobial agents in consumer products.

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“…However, in the peach-fruit production process, many by-products such as unripe fruit and branches are discarded. These discarded parts, especially woody part, may also have some biological activities; woody material contains rich polyphenols and they have some biological activities as reported in Sugi (Cryptomeria japonica) wood extract from many parts [7,8]. However, there is no information about biological activity in peach wood (including pruned branch), thus, this information will contribute to development in functional food industry.…”

mentioning

confidence: 99%

“…Compound 7 showed an extremely high value (8.06 mg TE/mg). Quercetin 3-O-β-D-glucopyranoside (7) has been indicated as one of the predominant contributors to the antioxidant activity [26]. Compounds 3, 4 and 6 showed relatively high values.…”

mentioning

confidence: 99%

Biological Activities of Extracts from Different Parts of two Cultivars of Prunus persica ‘Akatsuki’ and ‘Fastigiata’

Nakagawa

Allam

Ohnuki

2018

Natural Product Communications

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We investigated the antioxidant, anti-lipase and anti-dementia activities of peach (Prunus persica (L.) Batsch) fruit and its by-products. The ethanol extracts of branch showed relatively high activity in all biological activities. Then, the extract was fractionated, and eight compounds were isolated from the ethyl acetate fraction. Results showed 4,2',4'-trihydroxy-6'-methoxychalcone 4'-O-β-D-glucopyranoside (5) and quercetin 3-O-β-D-glucopyranoside (7) as newly identified compounds in P. persica. From the biological investigation, it was considered that quercetin 3-O-β-D-glucopyranoside (7) was the main active compound of antioxidant activity. The main active compound of anti-lipase activity in these was oleanolic acid (1). In addition, (+)-4'-O-methylcatechin (4), 4,2',4'trihydroxy-6'-methoxychalcone 4'-O-β-D-glucopyranoside (5) and ferulic acid (6) were the main active compounds of anti-dementia activity with acetylcholinesterase inhibitory assay. The results obtained suggested that these active compounds from peach branches of P. persica could be exploited as natural antioxidants, anti-lipase and anti-dementia materials in the future.

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Multiple uses of Essential Oil and By-Products from Various Parts of the Yakushima Native Cedar (Cryptomeria Japonica)

Cited by 22 publications

References 20 publications

Essential Oils and Their Main Chemical Components: The Past 20 Years of Preclinical Studies in Melanoma

Essential Oils and Their Main Chemical Components: The Past 20 Years of Preclinical Studies in Melanoma

<em>Leptospermum scoparium</em> (Mānuka) and <em>Cryptomeria japonica</em> (Sugi) Leaf Essential Oil Seasonal Chemical Variation and Their Effect on Antimicrobial Activity

Biological Activities of Extracts from Different Parts of two Cultivars of Prunus persica ‘Akatsuki’ and ‘Fastigiata’

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