Multiple verrucous carcinomas treated with acitretin

Kuan, Yue-Zon; Hsu, Hsiu-Cheng; Kuo, Tseng‐Tong; Huang, Yu‐Huei; Ho, Hung‐Yao

doi:10.1016/j.jaad.2006.01.043

Cited by 29 publications

(21 citation statements)

References 21 publications

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“…Acitretin, the second generation of retinoids, was reported to exhibit anti-tumour activity in actinic keratosis, verrucous carcinomas, SCC without significant side effects or toxicity [2,3,5,6]. However, the mechanism of its anti-carcinogenic effect is not fully understood.…”

Section: Discussionmentioning

confidence: 99%

“…Lebwohl et al [5] described a psoriatic patient developed multiple SCCs after long-term treatment with psoralen plus ultraviolet A and oral acitretin was administered to prevent the recurrence of skin cancer after surgical removal. Kuan et al [6] successfully treated a patient who had multiple, extensive verrucous carcinomas with a single regimen of acitretin. Acitretin have also shown to be effective in controlling and reducing actinic keratosis [3] and preventing the development of SCC in OTR [2, 7].…”

Section: Introductionmentioning

confidence: 99%

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Acitretin induces apoptosis through CD95 signalling pathway in human cutaneous squamous cell carcinoma cell line SCL‐1

Lin¹,

He²,

Tu³

et al. 2009

J Cellular Molecular Medi

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Skin cancers are by far the most common human malignancies. Retinoids have shown promising preventive and therapeutic effects against a variety of human malignancies. The aim of this study was to investigate the apoptosis-inducing effect of acitretin on human skin squamous cell carcinoma (SCC) SCL-1 cells. We found that acitretin preferentially inhibited the growth of SCL-1 cells in a dose- and time-dependent manner, but not of non-malignant keratinocyte HaCaT cells. This inhibition appeared to be due to induction of apoptosis as revealed by enzyme-linked immunosorbent assay. AnnexinV/propidium iodide assay and morphological observation confirmed the pro-apoptotic effect of acitretin on SCL-1 cells. We further demonstrated that apoptosis was induced within 1–2 days and involved activation of caspases-8, -9, -3 and poly (ADP-ribose) polymerase (PARP). Caspase-8 inhibitor effectively suppressed acitretin-induced apoptosis whereas caspase-9 inhibitor did not. Acitretin increased the levels of CD95 (Fas), CD95-ligand and Fas-associated death domain. Neutralizing ZB4 anti-Fas antibody significantly inhibited the apoptosis in SCL-1 cells induced by acitretin. These results suggest that acitretin is able to induce apoptosis in skin cancer cells possibly via death receptor CD95 apoptosis pathway without affecting the viability of normal keratinocyte.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Acitretin induces apoptosis through CD95 signalling pathway in human cutaneous squamous cell carcinoma cell line SCL‐1

Lin¹,

He²,

Tu³

et al. 2009

J Cellular Molecular Medi

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“…Five VCs were recognized in the present case. There are 3 reports of multiple VCs in other organs [7][8][9]. However, there are no reports of multiple VCs in the oral cavity.…”

Section: Discussionmentioning

confidence: 99%

“…All of them are solitary VC, and multiple VCs of the oral cavity have not been reported, to the best of the author's knowledge. Three cases of multiple VCs of other sites have been reported [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Multiple Verrucous Carcinomas of the Oral Cavity

Terada

2014

J. Maxillofac. Oral Surg.

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The author herein reports a case of multiple verrucous carcinomas (VCs) of the left lower gingiva. A 78-year-old man was admitted to our hospital because of gingival tumor. A biopsy revealed severe dysplasia. Surgical resection was performed. Grossly, there were three verrucous lesions (25, 20, 10 mm) in the left lower gingiva. Histologically, 2 tumors (4, 2 mm) were found in addition to the grossly visible 3 tumors. All the 5 tumors were VCs. The tumors showed verrucous and papillary proliferation of squamous epithelium with little cellular atypia. No invasive features were recognized. The dermis showed lymphocytic infiltration. The surrounding mucosa showed many broad foci of squamous cell carcinoma in situ and severe dysplasia (high grade intraepithelial neoplasm). Gradual merges between the VCs and squamous cell carcinoma in situ or severe dysplasia were frequently recognized. Immunohistochemically, the VC tumor cells and squamous lesions were negative for human papilloma virus antigens. P53 protein was expressed in all the VCs and squamous epithelial lesions: it was accentuated in the basal and suprabasal cells of VC. Ki-67 antigen was also expressed in the 5 VCs and in the squamous lesion, and Ki-67 labeling index ranged from 8 to 16 % in VC and from 37 to 62 % in the squamous lesions. These data support the multicentric nature of VC and that the severe dysplasiacarcinoma in situ sequence have been proposed in the etiology of VC.

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“…Reported treatment options for VP include both topical and systemic agents typically used in other forms of psoriasis, with anecdotal evidence supporting response to oral retinoids (2,6,8,9). It appears that this form of psoriasis only partially responds to biologics.…”

Section: Discussionmentioning

confidence: 99%

Erythrodermic verrucous psoriasis

Curtis

Yosipovitch

2011

Journal of Dermatological Treatment

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Verrucous psoriasis is characterized clinically by symmetric hypertrophic verrucous plaques on an erythematous base and histologically by overlapping features of both verrucae and psoriasis with negative human papilloma virus (HPV) studies. A 46-year-old African-American male presented with an 8-year history of extensive malodorous, symmetric, verrucous plaques manifesting as erythroderma. Biopsies showed epidermal hyperplasia and papillomatosis, parakeratosis with neutrophils, and dilated vessels in the dermal papillae. The polymerase chain reaction of lesional skin was negative for HPV DNA, and T-cell gene rearrangement was negative. The patient was diagnosed with erythrodermic verrucous psoriasis. Verrucous psoriasis is a rare presentation of psoriasis and has only been reported as a localized variant. To the authors' knowledge, erythrodermic verrucous psoriasis has not been reported. This presentation was a diagnostic and therapeutic challenge and serves to heighten the awareness of a unique variant of psoriasis.

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Multiple verrucous carcinomas treated with acitretin

Cited by 29 publications

References 21 publications

Acitretin induces apoptosis through CD95 signalling pathway in human cutaneous squamous cell carcinoma cell line SCL‐1

Acitretin induces apoptosis through CD95 signalling pathway in human cutaneous squamous cell carcinoma cell line SCL‐1

Multiple Verrucous Carcinomas of the Oral Cavity

Erythrodermic verrucous psoriasis

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