Multiplex Analysis of the Activation of the Immune System after Transection of the Rat’s Sciatic Nerve

Masgutova, Galina; Martynova, Ekaterina; Масгутов, Р. Ф.; Mukhametova, Liliya; Mullakhmetova, Adelya; Kadyrova, Gulnaz; Khaiboullina, Svetlana F.; Rizvanov, Albert A.

doi:10.1007/s12668-016-0332-8

Cited by 2 publications

(1 citation statement)

References 32 publications

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“…Thanks to the continuous development of technology and economy, people's living standards have also continued to improve, thereby driving the continuous development and upgrading of the transportation industry, automobile manufacturing industry and real estate construction industry. The middle leaf increased the risk of traffic safety accidents, industrial manufacturing production packaging accidents and accidental injuries, which also directly led to the increasing incidence of peripheral nerve injury [4]. In addition, many natural disasters caused by force majeure factors have caused an increase in the number of sciatic nerve injuries.…”

Section: Causes and Classification Of Sciatic Nerve Injurymentioning

confidence: 99%

Ultrasound Pathological Changes under Function and Microscope Observation after Sciatic Nerve in Rats

2021

IJPHPM

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The most common case of contemporary neuro-orthopedics and neurosurgery is sciatic nerve injury, but after the sciatic nerve is severed, it cannot be cured by medical surgery. Objective: To restore the damaged sciatic nerve to normal function. Methods: The rat model of sciatic nerve injury was made by operation after anastomosis of the sciatic nerve. A blank control group, model group and NT-3 treatment group were set up. Compare the recovery of rat sciatic nerve function and the pathological changes under the microscope before and after treatment. Results: The sciatic nerve function index of the rats before injury was all above 9, and the nerve function was completely normal. The SFI value of the high-dose group was close to 0 after the fourth week, which was significantly different from other groups (P <0.05), and its intensity Related to the concentration, the high-dose group had the most significant effect after statistical treatment; the recovery rate of calf triceps wet weight in the NT-3 high-dose group was higher than that of the other experimental groups, and the recovery rate at the sixth week was 77.35 %.The treatment effect is significant (P <0.01), the amplitude of the sciatic nerve action potential of rats before injury is higher than the amplitude of the sciatic nerve action potential of rats after injury, and the NT-3 high-dose group basically recovered to Normal nerve action potential amplitude (11.21). Conclusion: NT-3 can speed up the recovery of sciatic nerve function after sciatic nerve dissection.

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Section: Causes and Classification Of Sciatic Nerve Injurymentioning

confidence: 99%

Ultrasound Pathological Changes under Function and Microscope Observation after Sciatic Nerve in Rats

2021

IJPHPM

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Angiogenesis and nerve regeneration induced by local administration of plasmid pBud-coVEGF165-coFGF2 into the intact rat sciatic nerve

et al. 2021

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Multiplex Analysis of the Activation of the Immune System after Transection of the Rat’s Sciatic Nerve

Cited by 2 publications

References 32 publications

Ultrasound Pathological Changes under Function and Microscope Observation after Sciatic Nerve in Rats

Ultrasound Pathological Changes under Function and Microscope Observation after Sciatic Nerve in Rats

Angiogenesis and nerve regeneration induced by local administration of plasmid pBud-coVEGF165-coFGF2 into the intact rat sciatic nerve

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