Multiplex detection of breast cancer biomarkers using plasmonic molecular sentinel nanoprobes

Wang, Hsin‐Neng; Vo‐Dinh, Tuan

doi:10.1088/0957-4484/20/6/065101

Cited by 133 publications

(108 citation statements)

References 46 publications

Supporting

Mentioning

106

Contrasting

Order By: Relevance

“…GNS are exceptional light 'nano-enhancers' that have led to a wide range of chemical, biological and medical (both diagnostic and therapeutic) applications. For example, GNS exhibit intense surface-enhanced Raman scattering and two-photon luminescence and therefore provide an exceptional platform for nucleic acid biomarker detection [13,17], stem cell tracking [25,26] and tumor bioimaging [18,19].…”

Section: Plasmonic Nano-enhancers Of Lightmentioning

confidence: 99%

“…A special type of metallic nanoparticles, called 'plasmonic' nanoparticles, has received great interest because they exhibit enhanced optical and electromagnetic properties. Our fundamental studies of various plasmonic structures [8][9][10] and applied development of plasmonic nanoplatforms have led to a wide variety of applications ranging from chemical sensing [10][11][12] to cancer diagnostics [13][14][15][16][17] and therapy using nanoparticle-mediated photothermal treatment [15,[18][19][20]. Recently, we demonstrated that the use of plasmonic gold nanostars (GNS) in combination with immunotherapy -a treatment we referred to as Synergistic Immuno Photothermal Nanotherapy (SYMPHONY) -can dramatically enhance the efficacy of immunotherapy.…”

mentioning

confidence: 99%

See 1 more Smart Citation

What Potential Does plasmonics-amplified Synergistic Immuno Photothermal Nanotherapy have for Treatment of cancer?

Vo‐Dinh

Inman

2017

Nanomedicine (Lond.)

Self Cite

View full text Add to dashboard Cite

" Our results have indicated that by using a combination of immune-checkpoint inhibition and gold nanostar (GNS)-mediated photothermal therapy, it is possible to achieve complete eradication of primary treated tumors as well as distant untreated tumors tumors and induce long-term anti-cancer immunity in mice implanted with the MB49 bladder cancer cell line. " The war on cancer was declared almost half a century ago and yet the incidence of cancer is decreasing for only a handful of cancer types and most cancers that have spread beyond their organ of origin remain incurable. In fact, cancer is the most common cause of death in people aged less than 85 years and it is estimated that in 2012 there were more than 14.1 million new cancer cases worldwide and 8.2 million deaths that resulted [1].Nanomedicine has contributed to important advances in healthcare over the past few decades. In particular, the use of nanoparticles in medicine has attracted increased attention for their unique efficacy and specificity in therapy [2]. One exciting new development is nanoparticle-mediated thermal therapy which has demonstrated the potential for precise tumor cell ablation [3], radio-sensitization of hypoxic regions [4], enhancement of drug delivery [5], activation of thermosensitive agents [6] and enhancement of the immune system [7]. A special type of metallic nanoparticles, called 'plasmonic' nanoparticles, has received great interest because they exhibit enhanced optical and electromagnetic properties. Our fundamental studies of various plasmonic structures [8][9][10] and applied development of plasmonic nanoplatforms have led to a wide variety of applications ranging from chemical sensing [10][11][12] to cancer diagnostics [13][14][15][16][17] and therapy using nanoparticle-mediated photothermal treatment [15,[18][19][20]. Recently, we demonstrated that the use of plasmonic gold nanostars (GNS) in combination with immunotherapy -a treatment we referred to as Synergistic Immuno Photothermal Nanotherapy (SYMPHONY) -can dramatically enhance the efficacy of immunotherapy. Remarkably, we have found that SYMPHONY not only eradicates primary 'treated' tumors but also has resulted in the immune-mediated destruction of distant 'untreated' metastatic tumors [21]. This abscopal effect occurred uniquely when nanoparticle-mediated photothermal heating of tumors was used in combination with immunotherapy.Plasmonic nanoparticles have unique properties that allow them to amplify the optical properties of the excitation light and thus increase the effectiveness of light-based photothermal tumor ablation. The unique properties which contribute to plasmonics-amplified immune nanotherapy for cancer, include: plasmonic nano-enhancers of light, nano-targeting of tumor cells, nanosources for heating tumor cells from the inside, nano-activators of the immune system and synergistic amplification of immunomodulation. These elements are discussed in the following sections.

show abstract

Section: Plasmonic Nano-enhancers Of Lightmentioning

confidence: 99%

mentioning

confidence: 99%

What Potential Does plasmonics-amplified Synergistic Immuno Photothermal Nanotherapy have for Treatment of cancer?

Vo‐Dinh

Inman

2017

Nanomedicine (Lond.)

Self Cite

View full text Add to dashboard Cite

show abstract

“…Unique optical and plasmonic properties of metal nanoparticles are utilized as signal transducers for reporting oligonucleotide hybridization events. Multiplexed detection of breast cancer biomarkers in a homogeneous solution using SERS-based Molecular Sentinel (MS) technology was demonstrated recently (Wang and Vo-Dinh, 2009). Two MS nanoprobes, ERBB2-MS and KI67-MS, were designed to respectively target critical biomarkers for breast cancer, e.g., erbB-2 gene and Ki-67 gene.…”

Section: Silver Nanoparticles (Agnps)mentioning

confidence: 99%

Detection of Cancer Biomarkers With Nanotechnology

Zhang

et al. 2013

American Journal of Biochemistry and Biotechnology

View full text Add to dashboard Cite

Early detection of cancer biomarkers with high precision is critically important for cancer therapy. A variety of sensors based on different nanostructured materials have attracted intensive research interest due to their potential for highly sensitive and selective detection of cancer biomarkers. This review covers the use of a variety of nanostructured materials, including carbon nanotubes, silicon nanowires, gold nanoparticles and quantum dots, in the fabrication of sensors. Emphases are placed on how the detection systems work and what detection limits can be achieved. Some assays described in this review outperform established methods for cancer biomarker detection. It is highly promising that these sensors would soon move into commercial-scale production and find routine use in hospitals.

show abstract

“…The combination of SERS and fluorescent dye labelled DNA has been used successfully to detect the cystic fibrosis trans-membrane conductance regulator (CFTCR) gene, 14 sequences coding for methicillin-resistant Staphylococcus aureus (MRSA) 12,15 and furthermore Vo-Dinh et al developed a SERS-based assay using "molecular sentinels" for the multiplex detection of two biomarkers for breast cancer. 16 Meningitis is a result of inflammation of the lining around the spinal cord and brain. The majority of meningitis cases are viral in which case the treatment is directed at limiting the effects of the symptoms.…”

Section: Introductionmentioning

confidence: 99%

Bacterial meningitis pathogens identified in clinical samples using a SERS DNA detection assay

Gracie

Lindsay²,

Graham

et al. 2015

Anal. Methods

View full text Add to dashboard Cite

This version is available at https://strathprints.strath.ac.uk/53814/ Strathprints is designed to allow users to access the research output of the University of Strathclyde. Unless otherwise explicitly stated on the manuscript, Copyright © and Moral Rights for the papers on this site are retained by the individual authors and/or other copyright owners. Please check the manuscript for details of any other licences that may have been applied. You may not engage in further distribution of the material for any profitmaking activities or any commercial gain. You may freely distribute both the url (https://strathprints.strath.ac.uk/) and the content of this paper for research or private study, educational, or not-for-profit purposes without prior permission or charge.Any correspondence concerning this service should be sent to the

show abstract

Multiplex detection of breast cancer biomarkers using plasmonic molecular sentinel nanoprobes

Cited by 133 publications

References 46 publications

What Potential Does plasmonics-amplified Synergistic Immuno Photothermal Nanotherapy have for Treatment of cancer?

What Potential Does plasmonics-amplified Synergistic Immuno Photothermal Nanotherapy have for Treatment of cancer?

Detection of Cancer Biomarkers With Nanotechnology

Bacterial meningitis pathogens identified in clinical samples using a SERS DNA detection assay

Contact Info

Product

Resources

About