Multiplexed optical fiber sensors for dynamic brain monitoring

Zhang, Yuqian; Hu, Yubing; Li, Qiao; Lou, Kai; Wang, Shuhan; Zhang, Naihan; Jiang, Nan; Yetisen, Ali K.

doi:10.1016/j.matt.2022.07.024

Cited by 30 publications

(13 citation statements)

References 70 publications

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“…In contrast, optical fiber sensing method is more miniaturized, sensitive and can directly detect analytes in the target area with inserted fiber. [ 52 ] The integration of CNP‐based optical sensor with optical fiber device is promising to expand in vivo application scenarios, such as brain diseases. On the other hand, for sensing analytes in vitro, CNP‐based optical sensors mainly depend on the devices such as fluorescence spectrophotometer and μStat ECL instrument.…”

Section: Discussionmentioning

confidence: 99%

Cerium Oxide Nanoparticles‐Based Optical Biosensors for Biomedical Applications

Wang

Shi

et al. 2023

Advanced Sensor Research

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Optical sensing methods are especially attractive due to their low cost, rapid detection, and high sensitivity. Due to multiple enzyme‐mimetic activities, fast electron transfer capability, and biological molecules affinity, cerium oxide nanoparticle (CNP) represents a promising candidate to be used as the recognition and/or transducer element in optical biosensors. Despite the significant achievements of CNPs as therapeutic agents, the applications of CNPs as sensing elements are still in their infancy. To deepen the understanding and promote the development of CNP‐based optical biosensing, in this review, the ingenious design and fabrication of CNP‐based optical sensors are introduced, and the underlying sensing mechanisms are in‐depth analyzed. Furthermore, recent advances in CNP‐based optical sensing strategies for biomarker detection, disease diagnosis, and therapy are intensively discussed. Finally, current challenges and potential solutions of CNP‐based optical sensors for effective in vivo sensing are outlined.

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Section: Discussionmentioning

confidence: 99%

Cerium Oxide Nanoparticles‐Based Optical Biosensors for Biomedical Applications

Wang

Shi

et al. 2023

Advanced Sensor Research

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“…91 When packaged with suitable materials, the silicafiber optics is also a popular technique for the dynamic monitoring of the brain targets. Zhang et al developed a multiplexed fiber optic sensor coupling with an artificial intelligence platform, 86 as shown in Figure 5B. The endface of the fiber optic was fixed with the sensing films of the four biomarkers, namely pH, temperature, dissolved oxygen, and glucose levels.…”

Section: Wearable and Implanted Biosensorsmentioning

confidence: 99%

“…(B) Multiplexed fiber optic sensor coupling with artificial intelligence platform. 86 Copyright 2022, Elsevier. (C) A fiber-optic probe embedded with engineering cells and hydrogels enabled for the real-time detection of neurochemicals in the freely moving animals.…”

Section: Photosensitive Materials Off the Fiber Opticmentioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

“…Zhang et al. developed a multiplexed fiber optic sensor coupling with an artificial intelligence platform, 86 as shown in Figure 5B. The end‐face of the fiber optic was fixed with the sensing films of the four biomarkers, namely pH, temperature, dissolved oxygen, and glucose levels.…”

Section: Diagnosismentioning

confidence: 99%

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Advance on fiber optic‐based biosensors for precision medicine: From diagnosis to therapy

Luo,

Li,

Kong

et al. 2023

Interdisciplinary Medicine

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Precision medicine that takes individual variability into account is a new way to minimize the individual variability for precise diagnosis and to establish the certain strategies of efficient therapy. Due to miniaturization sensing area, remoting detection, and flexible operation of light, fiber optics have been successfully used to develop in vitro, wearable, and implanted biosensors, exhibiting high potential in precision medicine from the diagnosis in vitro to therapy in vivo. When modified with the recognition element, the fiber optic‐based biosensor enables the point of care testing for the detection of disease biomarkers. Meanwhile, the fiber optics packaged in a needle/catheter also monitor the medical Internet of things for the continuous assessment of human health. Moreover, the light from the cladding or leaky mode in the fiber optics excites the strong photothermal effect for therapy. The fiber optic‐based biosensor addressed the drawbacks of plasmonic photothermal therapy that limited penetration depths and non‐selectivity therapy. When integrated with a photothermal agent, the fiber optic‐based biosensors provide in situ information for the diagnosis as well as specifically and efficiently kill the tumor cells in deep tissues. In this review, we summarized the advances of fiber optic‐based biosensors in the diagnosis in vitro and therapy in vivo. The challenges and prospection of the fiber optic‐based biosensor application in precision medicine were also explored in depth.

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Soft Bioelectronics for Neuroengineering: New Horizons in the Treatment of Brain Tumor and Epilepsy

Yoo,

Kim,

Choi

et al. 2023

Adv Healthcare Materials

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Soft bioelectronic technologies for neuroengineering have shown remarkable progress, which include novel soft material technologies and device design strategies. Such technological advances that are initiated from fundamental brain science are applied to clinical neuroscience and provided meaningful promises for significant improvement in the diagnosis efficiency and therapeutic efficacy of various brain diseases recently. System‐level integration strategies in consideration of specific disease circumstances can enhance treatment effects further. Here, recent advances in soft implantable bioelectronics for neuroengineering, focusing on materials and device designs optimized for the treatment of intracranial disease environments, are reviewed. Various types of soft bioelectronics for neuroengineering are categorized and exemplified first, and then details for the sensing and stimulating device components are explained. Next, application examples of soft implantable bioelectronics to clinical neuroscience, particularly focusing on the treatment of brain tumor and epilepsy are reviewed. Finally, an ideal system of soft intracranial bioelectronics such as closed‐loop‐type fully‐integrated systems is presented, and the remaining challenges for their clinical translation are discussed.

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Multiplexed optical fiber sensors for dynamic brain monitoring

Cited by 30 publications

References 70 publications

Cerium Oxide Nanoparticles‐Based Optical Biosensors for Biomedical Applications

Cerium Oxide Nanoparticles‐Based Optical Biosensors for Biomedical Applications

Advance on fiber optic‐based biosensors for precision medicine: From diagnosis to therapy

Soft Bioelectronics for Neuroengineering: New Horizons in the Treatment of Brain Tumor and Epilepsy

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