2013
DOI: 10.1007/s00216-013-6963-5
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Multiplexed tyrosine kinase activity detection in cancer cells using a hydrogel immobilized substrate

Abstract: Kinases play a key role in cellular signaling, and the overactivation or overexpression of these kinases has been linked to a variety of cancers. Tyrosine kinase inhibitors treat the mechanism of these cancers by targeting the specific kinases that are overactive. Some patients, however, do not respond to these inhibitors or develop resistance to these inhibitors during treatment. Additionally, even within cancers of the same tissue type, different kinases may be overactive in different patients. For example, … Show more

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