Multipotent Mesenchymal Stromal Cells for Pulmonary Fibrosis?

Purdon, Stefanie; Patete, Carissa L.; Glassberg, Marilyn K.

doi:10.1016/j.amjms.2019.02.007

Cited by 8 publications

(3 citation statements)

References 19 publications

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“…Results using allogeneic telomerase negative MSCs, expressing MHC Class-I on their cell surfaces, demonstrated either stasis of disease progression, slowed disease progression, or no effect on disease progression with MSC transplantation [7,8,50,51,55,60,61,[64][65][66][67][68][69][70][71][72][73][74][75][76]90,92,95,96,99,103,106,107,[149][150][151]. These studies suggested that there was an immunomodulatory rather than a reparative effect of the MSCs with respect to the diseases treated.…”

Section: Resultsmentioning

confidence: 99%

Donor Selection is a Critical Component Using Naïve Endogenous Adult Stem Cells for the Treatment of Chronic Diseases and Traumatic Injuries

Young¹,

Speight²

2020

JRMBR

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Section: Resultsmentioning

confidence: 99%

Donor Selection is a Critical Component Using Naïve Endogenous Adult Stem Cells for the Treatment of Chronic Diseases and Traumatic Injuries

Young¹,

Speight²

2020

JRMBR

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“…Despite this, “stem cell” therapy remains largely unregulated worldwide. Leading countries in the area of regenerative medicine have thus joined forces to establish common regulatory measures to reinforce oversights and guarantee safety in this still rather unexplored scientific territory [104]. In 2017, Japan introduced strict legislation in response to international concerns about the indiscriminate and negligent use of stem cell therapy [105].…”

Section: Mesenchymal Stem Cellsmentioning

confidence: 99%

The Role of Mesenchymal Stem Cells in Radiation-Induced Lung Fibrosis

Zanoni

Cortesi

Zamagni

et al. 2019

IJMS

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Radiation therapy is one of the most important treatment modalities for thoracic tumors. Despite significant advances in radiation techniques, radiation-induced lung injury (RILI) still occurs in up to 30% of patients undergoing thoracic radiotherapy, and therefore remains the main dose-limiting obstacle. RILI is a potentially lethal clinical complication of radiotherapy that has 2 main stages: an acute stage defined as radiation pneumonitis, and a late stage defined as radiation-induced lung fibrosis. Patients who develop lung fibrosis have a reduced quality of life with progressive and irreversible organ malfunction. Currently, the most effective intervention for the treatment of lung fibrosis is lung transplantation, but the lack of available lungs and transplantation-related complications severely limits the success of this procedure. Over the last few decades, advances have been reported in the use of mesenchymal stem cells (MSCs) for lung tissue repair and regeneration. MSCs not only replace damaged lung epithelial cells but also promote tissue repair through the secretion of anti-inflammatory and anti-fibrotic factors. Here, we present an overview of MSC-based therapy for radiation-induced lung fibrosis, focusing in particular on the molecular mechanisms involved and describing the most recent preclinical and clinical studies carried out in the field.

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“…These two types of cells applied to different human tissue parts in transplantation. Although many researches had proved that hAMSCs could be capable of restricting the organ fibrosis and inhibiting the epithelial-to-mesenchymal transition, hAMSCs, as mesenchymal cells, could cause organ fibrosis by themselves in a long term [26-28]. Third, there are a lot of uncertain factors of the safety and reliability of hAMSCs in clinical application.…”

Section: Introductionmentioning

confidence: 99%

Producing Human Amniotic Epithelial Cells-only Membrane for Transplantation

Guo

Ahmed

et al. 2019

Preprint

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Human amniotic epithelial cells (hAECs), as pluripotent stem cells, have characteristics of immune privilege and great clinical potential. Here, we produced hAECs membrane consisting of single-layer hAECs and basal membrane (BM) of human amniotic membrane (hAM). In conventional methods, hAECs were isolated from hAM by repeated trypsin digestion. In this study, collagenase I and cell scraper were used to remove human amniotic mesenchymal stem cells (hAMSCs) from hAM and hAECs-only membranes were produced. These hAECs on the membranes were evaluated by surface biomarkers including epithelial cell adhesion molecule (EpCAM), stage-specific embryonic antigen 4 (SSEA4) and endoglin (CD105), transcriptional level of biomarkers including POU class 5 homeobox 1 (OCT4), sex determining region Y-box 2 (SOX2), fibroblast growth factor 4 (FGF4), immunofluorescence of cytokeratin-8 (CK-8), alpha smooth muscle actin (α-SMA) and collagen type I alpha 1 chain (ColA1). Finally, the hAECs membrane were transplanted on skin-removed mice to evaluate its effect on wound healing. In comparison to the hAECs isolated by the conventional methods, the cells isolated by this proposed method had higher purity of hAECs, expressed higher in pluripotency related genes, and maintained an epithelium construction in a long-term culture. In mice application, the hAECs membrane effectively improved the skin wound healing. An efficient method was successfully established to produce hAECs membrane in this work which not only held promise to obtain hAECs in higher purity and quality, but also showed practical clinical potential.

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Multipotent Mesenchymal Stromal Cells for Pulmonary Fibrosis?

Cited by 8 publications

References 19 publications

Donor Selection is a Critical Component Using Naïve Endogenous Adult Stem Cells for the Treatment of Chronic Diseases and Traumatic Injuries

Donor Selection is a Critical Component Using Naïve Endogenous Adult Stem Cells for the Treatment of Chronic Diseases and Traumatic Injuries

The Role of Mesenchymal Stem Cells in Radiation-Induced Lung Fibrosis

Producing Human Amniotic Epithelial Cells-only Membrane for Transplantation

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