Multipronged diagnostic and therapeutic strategies for Alzheimer's disease

Abstract

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and a major contributor to dementia cases worldwide. AD is clinically characterized by learning, memory, and cognitive deficits. Accumulation of extracellular amyloid...

Pathogenesis of Alzheimer’s Disease and Diversity of 1,2,3-Triazole Scaffold in Drug Development: Design Strategies, Structural Insights, and Therapeutic Potential

“…Apart from being a versatile linker, it is the first choice for development of multitargeting anti-Alzheimer’s hybrid molecules . However, various critically important reports on anti-Alzheimer’s and diagnostic derivatives in general or focused in triazole nucleus are available in the literature but none of them have explained the exclusive potential of 1,2,3-triazole nucleus in Alzheimer drug development. − Thus, a manuscript with sound analysis of the pathophysiology of Alzheimer’s disease and critical pharmacological as well as structural analysis of especially 1,2,3-triazole containing preclinical candidates is urgently needed. A wide range of derivatives containing 1,2,3-triazole nuclei have been reported by various research groups as potential anti-Alzheimer’s agents in preclinical studies.…”

Role of Metal Cations of Copper, Iron, and Aluminum and Multifunctional Ligands in Alzheimer’s Disease: Experimental and Computational Insights

“…AD is a multifactorial disease; the risk factors are both genetic and environmental, and it is still not possible to point out among its characteristics which is a cause or consequence, giving rise to many hypotheses looking forward to clarify the root cause of the disease but without certainty about which of them is the most determinant. A variety of diagnostic imaging methods and therapeutic strategies for many AD targets were reviewed by Ramesh et al 5 The pathological hallmarks involved in AD are extensive, but among the most recognized and studied are those related to the aberrant processing of brain proteins and its consequences. However, throughout the years the research field has been evolving to the design of pharmacological agents able to tackle multiple targets of the disease.…”

“…AD is a multifactorial disease; the risk factors are both genetic and environmental, and it is still not possible to point out among its characteristics which is a cause or consequence, giving rise to many hypotheses looking forward to clarify the root cause of the disease but without certainty about which of them is the most determinant. A variety of diagnostic imaging methods and therapeutic strategies for many AD targets were reviewed by Ramesh et al 5 …”

Multifunctional theranostic carbazole-based cyanine for real-time imaging of amyloid-β and therapeutic treatment of multiple pathologies in Alzheimer's disease

“…Over the years, various smart fluorescent probes have been developed for selective detection and imaging of Ab plaques. [17][18][19][20][21][22][23] Carbazole-based cyanine is an intriguing class of multifunctional fluorophores for AD as it exhibits not only desirable in vivo and ex vivo imaging properties for Ab species, but also attractive in vivo therapeutic potential for the treatment of AD. [24][25][26][27] Importantly, its molecular and biological properties can easily be tuned by modifying the R substituent on the quinolinium ring (Fig.…”