Multiresidue analysis of 22 sulfonamides and their metabolites in animal tissues using quick, easy, cheap, effective, rugged, and safe extraction and high resolution mass spectrometry (hybrid linear ion trap-Orbitrap)

Food Sample Preparation for the Determination of Sulfonamides by High-Performance Liquid Chromatography: State-of-the-Art

“…In the case of animal tissue samples, SLE [31][32][33], ASE [34][35][36], QuEChERS extraction [37,38], SALLE [40,41], and SPE [42] were the most reported methodologies for the extraction of SAs, along with other antibiotic or veterinary drugs, followed by reports of USE [36], DSPE [45], and SBSE [48]. Reports of on-line techniques include a fully automated on-line QuEChERS extraction protocol [39] and an on-line SPME protocol that utilized molecularly imprinted monolithic capillary columns [47].…”

“…The mixture was centrifuged at 3500 rpm for 5 min, the supernatant (6 mL) was collected, mixed with primary secondary amine (PSA) (150 mg) and anhydrous MgSO 4 (900 mg), and the mixture was shaken, vortexed, and centrifuged as described. The supernatant (4 mL) was collected and evaporated to dryness under nitrogen stream at 35 • C. The residue was dissolved in 0.01% formic acid in 5% MeOH aqueous solution (500 µL), passed through a 0.22 µm nylon filter, and centrifuged at 13,500 rpm for 10 min prior to high-performance liquid chromatography-high-resolution mass spectrometry (HPLC-HRMS) analysis [37]. In the second report, a modified QuEChERS extraction protocol was developed for the extraction of eight SAs from chicken muscle and egg sample.…”

Monitoring of twenty-two sulfonamides in edible tissues: Investigation of new metabolites and their potential toxicity

“…Extraction and clean-up were based on QuEChERS extraction as previously described (Abdallah et al, 2014). In brief, a 5 g finely ground sample of meat was weighed and spiked with SMX-D 4 (internal standard) at 100 lg kg À1 .…”

“…In our study SAs were investigated in various meat samples collected in Lebanon in order to obtain data concerning potential contamination of meats with these frequently used drugs in livestock. We aimed at (i) collecting samples of muscle, liver and kidneys from chicken, beef and sheep randomly from animal farms and slaughterhouses in nine different areas in Lebanon; (ii) analyzing samples following our recently reported methodology (Abdallah, Arnaudguilhem, Jaber, & Lobinski, 2014); (iii) investigating the presence of SA metabolites in the most contaminated samples, and (iv) predicting the toxicity of detected SAs and its metabolites using a computer-based model.…”

Quantitative analysis of poly- and perfluoroalkyl compounds in water matrices using high resolution mass spectrometry: Optimization for a laser diode thermal desorption method

“…Although HRMS is traditionally applied for qualitative or semi-quantitative purposes, Henry et al [30] have further suggested that HRMS might emerge as a serious alternative to QqQ mass spectrometry in the field of routine analysis, despite the relatively affordable cost of the latter. Several recently published papers have indeed reported the use of orbitrap technology for quantitative multi-residue methods [31,32].…”