Multiresidue Determination of Pesticides in Lanolin Using Matrix Solid-Phase Dispersion

Pérez, Andrés; González, Gabriel; González, Joaquín; Heinzen, Horacio

doi:10.1093/jaoac/93.2.712

Cited by 9 publications

(2 citation statements)

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“…Modern day lanolin undergoes a complex refinement process in order to obtain a highly purified lanolin ingredient from raw wool wax; this is necessary as the raw material may be contaminated with environmental impurities such as pesticide residues, detergents used in the wool scouring process and salts [ 9 ]. Pesticides are used to prevent fleece damage by sheep ectoparasites and to protect wool during storage; historically, the most commonly used were organochlorine, organophosphorus and pyrethroid insecticides [ 10 ]. Due to the lipophilic nature of these pesticides, they accumulate in wool wax [ 9 ] and their environmental persistence means they are still a common contaminant of wool grease to this day.…”

Section: Introductionmentioning

confidence: 99%

Multi-residue analysis of certain lanolin nipple care products for trace contaminants

Bourdillon¹,

McCausland²,

McCabe³

2023

BMC Chemistry

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Background Topical lanolin is commonly used on nipples to aid breastfeeding success. The raw material undergoes refinement to remove contaminants such as pesticides, which may accumulate from exogenous environmental sources. The level of refinement influences final lanolin purity. For use in nipple creams, a lanolin which complies with a published monograph (either USP or Ph. Eur.) is desirable to ensure a non-toxic product with neutral taste and smell, and low allergenicity. Methods The aim of this study was to determine the residual trace pesticide levels and quantify the Free Lanolin Alcohols (FLA) levels in two commercially available lanolin products (HPA LANOLIN (Lansinoh Laboratories Inc.); PURELAN (Medela AG)) and two lanolin ingredients (PHARMALAN PH EU-SO-(RB) and CORONA-8 SO-(RB) (Croda, Goole, UK)) using established validated methods. Test samples were subjected to Gas-Chromatographic and Liquid-Chromatographic analysis to quantify and identify a panel of 178 pesticide residues. FLA levels and the presence of oxidative metabolites were also determined. Results The purity of the lanolin ingredients was consistent with expectations based on their level of refinement; lanolin in compliance with the Ph. Eur. monograph demonstrated the highest level of purity. Differences were seen between the lanolin nipple creams tested, in terms of FLA levels and pesticide residue levels. Specifically, the HPA LANOLIN contained an extremely low level of FLA (0.61%), which was fourfold less than in the PURELAN (2.76%). Additionally, the HPA LANOLIN did not contain any detectable pesticide residues. The PURELAN was found to contain a number of pesticide residues, however the detected levels were low and within the permitted limits and so despite their presence, the PURELAN was still compliant with the relevant monographs. Conclusions This data reinforces that the purity of monograph compliant Lanolin makes it suitable for use on the nipples of breastfeeding mothers. A higher level of refinement leads to a reduction in pesticide contaminants also reduces FLA levels in the final material, minimizing the risk of allergenicity.

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Section: Introductionmentioning

confidence: 99%

Multi-residue analysis of certain lanolin nipple care products for trace contaminants

Bourdillon¹,

McCausland²,

McCabe³

2023

BMC Chemistry

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“…Lanolin is a lipid secretion from sebaceous glands of wool‐bearing animals like sheep. In terms of composition, it is a complex mixture of fatty acids with fatty alcohols, sterols, diesters, long‐chain alcohols, long‐chain fatty acids, and hydroxy acids 1 . Lanolin is actually nature's way of protecting animal wool and skin from atrocities of extreme climate and the environment.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of multiresidue method for organophosphorus pesticides in lanolin using gas chromatography–tandem mass spectrometry

et al. 2022

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Lanolin, also known as wool wax, is derived from sheep and has diverse applications in food, cosmetic, textile and lubricant industries. Owing to its direct contact with human, there is a need of studying pesticide residues as contaminants in lanolin. The present study describes a single novel hyphenated gas chromatography-tandem mass spectrometry (GC-MS/MS) technique for the quantification of 14 organophosphorus (OP) pesticides (tecnazene, propetamphos, diazinon, dichlofenthion, chlorpyrifos methyl, fenchlorphos, malathion, chlorpyrifos, pirimiphos ethyl, bromophos ethyl, tetrachlorvinphos, ethion, phosalone, and coumaphos) in lanolin using electrospray ionization (EI) with multiple reaction monitoring (MRM) acquisition mode. The method is simple in terms of sample preparation steps based on matrix solid-phase dispersion (MSPD). The method was found to be linear over the analytical range of 0.05-2.0 μg/g, with acceptable coefficient of determination (r 2 ≥ 0.99) for all the 14 pesticides. The limit of detection (LOD) and limit of quantification (LOQ) of the method were found to be less than 0.05 and 0.1 μg/g, respectively, for all the 14 OP pesticide residues. The precision and accuracy of the method were found to be within the acceptable limits, that is, recoveries in the range of 83.5%-104.1% with less than 12.5% of relative standard deviation for all the pesticides. The multiresidue method for estimating pesticide residues employing GC-MS/MS technique will be useful for OP pesticide levels in large number of lanolin samples.

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Multiresidual Determination of 295 Pesticides and Chemical Pollutants in Animal Fat by Gel Permeation Chromatography (GPC) Cleanup Coupled with GC–MS/MS, GC–NCI‐MS, and LC–MS/MS

Cao

Liu

Wang

et al. 2014

High‐Throughput Analysis for Food Safety

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Multiresidue Determination of Pesticides in Lanolin Using Matrix Solid-Phase Dispersion

Cited by 9 publications

References 0 publications

Multi-residue analysis of certain lanolin nipple care products for trace contaminants

Multi-residue analysis of certain lanolin nipple care products for trace contaminants

Development and validation of multiresidue method for organophosphorus pesticides in lanolin using gas chromatography–tandem mass spectrometry

Multiresidual Determination of 295 Pesticides and Chemical Pollutants in Animal Fat by Gel Permeation Chromatography (GPC) Cleanup Coupled with GC–MS/MS, GC–NCI‐MS, and LC–MS/MS

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