Multisite, Randomized Trial of Early Integrated Palliative and Oncology Care in Patients with Advanced Lung and Gastrointestinal Cancer: Alliance A221303

Temel, Jennifer S.; Sloan, Jeff A.; Zemla, Tyler; Greer, Joseph A.; Jackson, Vicki A.; El‐Jawahri, Areej; Kamdar, Mihir; Kamal, Arif H.; Blinderman, Craig D.; Strand, Jacob J.; Zylla, Dylan; Daugherty, Christopher K.; Furqan, Muhammad; Obel, Jennifer; Razaq, Mohammad; Roeland, Eric; Loprinzi, Charles L.

doi:10.1089/jpm.2019.0377

Cited by 40 publications

(49 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, 15% of PC patients received no PC visits, and only 49% of registrants completed the instruments at 12 weeks. 35 Future studies may benefit from having more than two sites and also more rigorously evaluating issues of intervention fidelity. Other study designs may be considered for future trials, such as cluster randomization.…”

Section: Dropoutsmentioning

confidence: 99%

A Palliative Care Intervention for Patients on Phase 1 Studies

Ferrell

Chung

Hughes

et al. 2021

Journal of Palliative Medicine

View full text Add to dashboard Cite

Background: Phase 1 clinical trials remain vital for oncology care. Patients on these trials require supportive care for quality-of-life (QOL) concerns. Objective: To test a Palliative Care Intervention (PCI) for patients with solid tumors enrolled in Phase I therapeutic trials with a priori hypothesis that psychological distress, QOL, satisfaction, symptoms, and resource utilization would be improved in the PCI group. Design: This unblinded randomized trial compared the PCI with usual care in patients accrued to Phase I Clinical Trials. Subjects (n = 479) were followed for 24 weeks, with 12 weeks as the primary outcome. Setting: Two Comprehensive Cancer Centers in the United States. Subjects: A consecutive sample, 21 years or older, English fluency, with solid tumors initiating a Phase 1 trial. Measurements: Psychological Distress (Distress Thermometer), QOL total and subscales (FACT-G), satisfaction (FAM-CARE), survival, and resource utilization (chart audit). Results: PCI subjects showed improved Psychological Distress (-0.47, p = 0.015) and Emotional Well-Being (0.81, p = 0.045), with differences on variables of QOL and distress between sites. High rates of symptommanagement admissions (41.3%) and low rates of Advance Directive completion (39.0%), and hospice enrollment (30.7%), despite a median survival in both groups of 10.1 months from initiating a Phase 1 study. Conclusions: A nurse-delivered PCI can improve some QOL outcomes and distress for patients participating in Phase 1 trials. Greater integration of PC is needed to provide quality care to these patients and to support transitions from treatment to supportive care, especially at the end of life. ClinicalTrials.gov Identifier: NCT01612598.

show abstract

Section: Dropoutsmentioning

confidence: 99%

A Palliative Care Intervention for Patients on Phase 1 Studies

Ferrell

Chung

Hughes

et al. 2021

Journal of Palliative Medicine

View full text Add to dashboard Cite

show abstract

“…Unexpectedly, patients with lung cancer reported an improvement in mood and depression, but patients with gastrointestinal cancer did not. In the most recent randomized cooperative group trial by Temel et al, performed at 18 academic and community sites, there was minimal—if any—effect [22]. There were attempts to use the same standardized methods for fidelity, but this was not verified.…”

Section: Figurementioning

confidence: 99%

The Impact of Palliative Care Dose Intensity on Outcomes for Patients with Cancer

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Previous studies suggest that palliative care—in effect, attempting to palliate any and all symptoms in patients with advanced cancer—results in favorable outcomes, including an improvement in survival. However, in this second publication, Temel and others reported on a multi-site trial from the Alliance for Clinical Trials in Oncology [ 2 ••]. This 391-patient trial tested early integrated palliative care plus oncology care versus usual oncology care.…”

Section: Introductionmentioning

confidence: 99%

Should Loss of Appetite Be Palliated in Patients with Advanced Cancer?

Ehret

Jatoi

2021

Curr. Treat. Options in Oncol.

View full text Add to dashboard Cite

Opinion statement Loss of appetite is common among patients with advanced cancer. However, it remains controversial how, when, and if to palliate this symptom. Here, we provide an update on recent as well as past literature to address the question of whether loss of appetite should be palliated in patients with advanced cancer. In our opinion—and as discussed here—we believe that this symptom should be palliated, although perhaps not always with pharmacologic interventions.

show abstract

Multisite, Randomized Trial of Early Integrated Palliative and Oncology Care in Patients with Advanced Lung and Gastrointestinal Cancer: Alliance A221303

Cited by 40 publications

References 30 publications

A Palliative Care Intervention for Patients on Phase 1 Studies

A Palliative Care Intervention for Patients on Phase 1 Studies

The Impact of Palliative Care Dose Intensity on Outcomes for Patients with Cancer

Should Loss of Appetite Be Palliated in Patients with Advanced Cancer?

Contact Info

Product

Resources

About