Multispectral optoacoustic tomography for in vivo detection of lymph node metastases in oral cancer patients using an EGFR-targeted contrast agent and intrinsic tissue contrast: A proof-of-concept study

Vonk, Jasper; Kukačka, Jan; Steinkamp, Pieter; Wit, Jaron G de; Voskuil, Floris; Hooghiemstra, Wouter T R; Bader, Maximilian; Jüstel, Dominik; Ntziachristos, Vasilis; Dam, Gooitzen M. van; Witjes, Max

doi:10.1016/j.pacs.2022.100362

Cited by 19 publications

(16 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, capturing of dedicated exogenous chromophores by spectral unmixing, such as indocyanine green, opens up completely new areas of applications [20] . However, for better understanding of spectral coloring in human deep tissue, larger clinical datasets are needed, to explore advanced depth correction or to apply blind source spectral unmixing methods [19] , [21] , [22] , [23] . To facilitate the latter analysis in research collaborations, studies should be performed according to guidelines in the field [24] , [25] and adhere to the recommendations of the International Photoacoustic Standardization Consortium (IPASC) [26] .…”

Section: Discussionmentioning

confidence: 99%

Multispectral optoacoustic tomography of the human intestine – temporal precision and the influence of postprandial gastrointestinal blood flow

et al. 2023

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Multispectral optoacoustic tomography of the human intestine – temporal precision and the influence of postprandial gastrointestinal blood flow

et al. 2023

View full text Add to dashboard Cite

“…In comparison to molecular endoscopy [17,40], which uses similar principles, targeted CE-MSOT with oral administration may avoid any invasive imaging procedures. However, prior targeted optoacoustic imaging studies using intravenous application of either cetuximab-800CW [41] or panitumumab-IRDye800CW [42] for detection of cancer metastasis showed heterogeneous results. The amounts of imaging agents given via systematic circulation might not have been su cient to produce enough signal in comparison to background noise.…”

Section: Discussionmentioning

confidence: 99%

Contrast-enhanced Multispectral Optoacoustic Tomography for Functional Assessment of the Gastrointestinal Tract

Knieling

Paulus

Buehler

et al. 2022

Preprint

View full text Add to dashboard Cite

Real-time imaging and functional assessment of the intestinal tract and its transit poses a significant challenge to traditional clinical diagnostic methods. Multispectral optoacoustic tomography (MSOT), a molecular-sensitive imaging technology, offers the potential to visualize endogenous and exogenous chromophores in tissue. Herein we present a novel approach using the orally administered clinical-approved fluorescent dye indocyanine green (ICG) for bed-side, non-ionizing evaluation of gastrointestinal passage. We were able to show the detectability and stability of ICG in phantom experiments. Furthermore, ten healthy subjects underwent MSOT imaging at multiple timepoints over eight hours after ingestion of a standardized meal with and without ICG. ICG signals could be visualized and quantified in different intestinal segments, while its excretion was confirmed by fluorescent imaging of stool samples. These findings indicate that contrast-enhanced MSOT (CE-MSOT) provides a translatable real-time imaging approach for functional assessment of the gastrointestinal tract.

show abstract

“…Because PA signals are delivered in the form of US waves, conventional US transducers and image reconstruction systems can also be used for PA image generation. However, the information in the resulting PA images is the optical absorption characteristics of the biological tissue, which can be converted into molecular functional information, including hemoglobin oxygen saturation [ 46 , 47 , 48 , 49 ], hemodynamic responses [ 50 , 51 , 52 ], and agent uptake [ 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 ]. Therefore, various PA agents have been demonstrated to possess theranostic applications in vivo.…”

Section: Principles Of Photoacoustic-guided Phototherapymentioning

confidence: 99%

Recent Advances in Photoacoustic Agents for Theranostic Applications

et al. 2023

View full text Add to dashboard Cite

Photoacoustic agents are widely used in various theranostic applications. By evaluating the biodistribution obtained from photoacoustic images, the effectiveness of theranostic agents in terms of their delivery efficiency and treatment responses can be analyzed. Through this study, we evaluate and summarize the recent advances in photoacoustic-guided phototherapy, particularly in photothermal and photodynamic therapy. This overview can guide the future directions for theranostic development. Because of the recent applications of photoacoustic imaging in clinical trials, theranostic agents with photoacoustic monitoring have the potential to be translated into the clinical world.

show abstract

Multispectral optoacoustic tomography for in vivo detection of lymph node metastases in oral cancer patients using an EGFR-targeted contrast agent and intrinsic tissue contrast: A proof-of-concept study

Cited by 19 publications

References 61 publications

Multispectral optoacoustic tomography of the human intestine – temporal precision and the influence of postprandial gastrointestinal blood flow

Multispectral optoacoustic tomography of the human intestine – temporal precision and the influence of postprandial gastrointestinal blood flow

Contrast-enhanced Multispectral Optoacoustic Tomography for Functional Assessment of the Gastrointestinal Tract

Recent Advances in Photoacoustic Agents for Theranostic Applications

Contact Info

Product

Resources

About