Multistage adaptive noise reduction technique for optical resolution photoacoustic microscopy

Guezzi, Nizar; Lee, Chang-Ho; Le, Thanh Dat; Seong, Hyojin; Choi, Kang‐Ho; Min, Jung‐Joon; Yu, Jaesok

doi:10.1002/jbio.202200164

Journal of Biophotonics

2022

DOI: 10.1002/jbio.202200164

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Multistage adaptive noise reduction technique for optical resolution photoacoustic microscopy

Nizar Guezzi

Chang-Ho Lee

Thanh Dat Le

et al.

Abstract: Photoacoustic microscopy has received great attention due to the benefits of the optical resolution contrast as well as its superior spatial resolution and relatively deep depth. Like other imaging modalities, photoacoustic images suffer from noise, and filtering techniques are required to remove them. To overcome the

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Cited by 5 publications

References 41 publications

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High‐resolution in vivo imaging of human nailbed microvasculature by using photoacoustic microscopy

Zhao

Tao

et al. 2023

Journal of Biophotonics

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Microcirculation imaging has significantly clinical value in early diagnosis and curative effect judgment of various diseases. The most superficial layer of the nailbed is rich in capillaries, which is suitable as a window on the microcirculation. However, few techniques can noninvasively observe the blood supply distribution of the nailbed, especially for high-resolution imaging of capillaries. In this study, we adapted an opticalresolution photoacoustic microscopy (OR-PAM) to image the nailbed microvasculature. The imaging sensitivity was significantly improved by hydration pretreatment of the nail. In vitro phantom experiments demonstrate that the sensitivity was improved about 3.5 times after hydration. In vivo imaging experiments of the nailbed microvasculature were conducted to further examine the enhanced sensitivity and practicability of OR-PAM. Moreover, the quantitative analysis of capillary loops showed that OR-PAM can extract the detection indicators including vascular morphology, diameter, and length, which provides a basis for clinical microcirculation detection using OR-PAM.

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High‐resolution in vivo imaging of human nailbed microvasculature by using photoacoustic microscopy

Zhao

Tao

et al. 2023

Journal of Biophotonics

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Enhanced resolution and sensitivity acoustic-resolution photoacoustic microscopy with semi/unsupervised GANs

Le,

Min,

Lee

2023

Sci Rep

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Acoustic-resolution photoacoustic microscopy (AR-PAM) enables visualization of biological tissues at depths of several millimeters with superior optical absorption contrast. However, the lateral resolution and sensitivity of AR-PAM are generally lower than those of optical-resolution PAM (OR-PAM) owing to the intrinsic physical acoustic focusing mechanism. Here, we demonstrate a computational strategy with two generative adversarial networks (GANs) to perform semi/unsupervised reconstruction with high resolution and sensitivity in AR-PAM by maintaining its imaging capability at enhanced depths. The b-scan PAM images were prepared as paired (for semi-supervised conditional GAN) and unpaired (for unsupervised CycleGAN) groups for label-free reconstructed AR-PAM b-scan image generation and training. The semi/unsupervised GANs successfully improved resolution and sensitivity in a phantom and in vivo mouse ear test with ground truth. We also confirmed that GANs could enhance resolution and sensitivity of deep tissues without the ground truth.

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Photoacoustic/ultrasound dual-modal imaging of human nails: A pilot study

Wen,

Huang,

Huang

et al. 2024

J. Innov. Opt. Health Sci.

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Traditional diagnostic techniques including visual examination, ultrasound (US), and magnetic resonance imaging (MRI) have limitations of in-depth information for the detection of nail disorders, resolution, and practicality. This pilot study, for the first time, evaluates a dual-modality imaging system that combines photoacoustic tomography (PAT) with the US for the multiparametric quantitative assessment of human nail. The study involved a small cohort of five healthy volunteers who underwent PAT/US imaging for acquiring the nail unit data. The PAT/US dual-modality imaging successfully revealed the fine anatomical structures and microvascular distribution within the nail and nail bed. Moreover, this system utilized multispectral PAT to analyze functional tissue parameters, including oxygenated hemoglobin, deoxyhemoglobin, oxygen saturation, and collagen under tourniquet and cold stimulus tests to evaluate changes in the microcirculation of the nail bed. The quantitative analysis of multispectral PAT reconstructed images demonstrated heightened sensitivity in detecting alterations in blood oxygenation levels and collagen content within the nail bed, under simulated different physiological conditions. This pilot study highlights the potential of PAT/US dual-modality imaging as a real-time, noninvasive diagnostic modality for evaluating human nail health and for early detection of nail bed pathologies.

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Multistage adaptive noise reduction technique for optical resolution photoacoustic microscopy

Cited by 5 publications

References 41 publications

High‐resolution in vivo imaging of human nailbed microvasculature by using photoacoustic microscopy

High‐resolution in vivo imaging of human nailbed microvasculature by using photoacoustic microscopy

Enhanced resolution and sensitivity acoustic-resolution photoacoustic microscopy with semi/unsupervised GANs

Photoacoustic/ultrasound dual-modal imaging of human nails: A pilot study

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