The influence of melting-casting and heat treatment processes on the hardness of 2618 aluminum alloy was investigated by hardness testing. The results show that the hardness of 2618 alloy increases at first and then decreases with the prolongation of melt holding time, and the hardness reaches the peak value when the holding time is 30 min. With the increase of melting-casting temperature, the hardness of the alloy increases rapidly at first and then decreases slightly. The hardness of the alloy first increases and then tends to be stable as the homogenization temperature rises and decreases rapidly, and then tends to be stable with the extension of melt holding time. Moreover, the effect of homogenization temperature on the hardness is more obvious. With the increase of aging temperature, the hardness of 2618 alloy increases first and then decreases, and the hardness of the alloy increases sharply first and then decreases with the increase of aging time. The hardness of the alloy reaches the peak value of 68.88 HRB after aging at 190 °C for 12 h.