Multistage-responsive clustered nanosystem to improve tumor accumulation and penetration for photothermal/enhanced radiation synergistic therapy

Hua, Shiyuan; He, Jian; Zhang, Fengping; Yu, Jianghao; Zhang, Wenxia; LanYing, Gao; Li, Yangyang; Zhou, Min

doi:10.1016/j.biomaterials.2020.120590

Cited by 63 publications

(41 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 15,16 ] The physicochemical properties, including particle size, shape, and surface can primarily influence the behavior of nanoparticle in tumor accumulation and penetrability. Considering that, many researchers attempted to design the nanocarriers rationally by switching particle size and shape, altering surface charge and modifying targeting ligands to improve the penetration efficiency [ 16–18 ] Besides, another strategy is to remodel the internal tumor structure by modulating the tumor vasculature and disrupting dense physical extracellular matrix (ECM) barrier that obstacles the diffusion of nanocarriers. [ 19,20 ] As reported, some external stimuli including ultrasound, radiation and NIR laser were deployed to improve the permeability of tumor vasculature and tissue, thus enhancing nanoparticle accumulation in deep tumor tissue.…”

Section: Introductionmentioning

confidence: 99%

Biocompatible Nanomotors as Active Diagnostic Imaging Agents for Enhanced Magnetic Resonance Imaging of Tumor Tissues In Vivo

Zheng

Wang

Pan

et al. 2021

Adv Funct Materials

View full text Add to dashboard Cite

The limited penetration of imaging agents in solid tumor tissue and cells remains a great challenge to achieve ideal visibility in cancer diagnosis. Herein, a near infrared (NIR) light‐driven Janus mesoporous silica nanomotor (JMS nanomotor) to promote magnetic resonance (MR) imaging in vivo is developed. The JMS nanomotors are prepared by depositing Au on the half‐sphere surface of gadolinium‐doped mesoporous silica nanoparticles. Under NIR irradiation, the nanomotors achieve efficient propulsion through thermophoresis in biological media. To prove the ability of nanomotors as active diagnostic imaging agents, both in vitro and in vivo experiments are carried out. In vitro studies confirm that NIR light can actively propel the JMS nanomotors to effectively seek, adhere to, and mechanically perforate the tumor cells to enhance the cellular uptake and MR imaging. To move a step further, in vivo investigations show that the JMS nanomotors also exhibit improved accumulation and deep penetration in the solid tumor model when exposed to NIR laser, where the MR imaging contrast is significantly enhanced in the majority of tumor tissue. Such JMS nanomotors provide new insight in precise cancer diagnosis and meanwhile MR imaging offers a new tool for real‐time tracking of nanomotors in vivo.

show abstract

Section: Introductionmentioning

confidence: 99%

Biocompatible Nanomotors as Active Diagnostic Imaging Agents for Enhanced Magnetic Resonance Imaging of Tumor Tissues In Vivo

Zheng

Wang

Pan

et al. 2021

Adv Funct Materials

View full text Add to dashboard Cite

show abstract

“…[ 161 ] Compared to PDT and CT, PTT holds many superiorities, such as negligible system side effects, no reliance on the O 2 , and without drug resistance compared with CT. [ 163 ] Furthermore, the PTT increasing permeability and blood circulation contributes to internalization and deep penetration. [ 162 ] Based on the precisely controlled NIR laser in the local tumor, TAAs are released as a powerful support to inefficient antigens in situ. The photo‐responsive IR820−1MT NP was demonstrated with significantly enhanced accumulations of helper T cells and cytotoxic T cells while inhibited amounts of regulatory T cells.…”

Section: Exo‐stimuli‐responsive Nanoparticles (Ex‐srnps) For Smart Dr...mentioning

confidence: 99%

Stimuli‐Responsive Nanoparticles for Controlled Drug Delivery in Synergistic Cancer Immunotherapy

Zhang

Lin

Lin³

et al. 2021

Advanced Science

157

View full text Add to dashboard Cite

Cancer immunotherapy has achieved promising clinical progress over the recent years for its potential to treat metastatic tumors and inhibit their recurrences effectively. However, low patient response rates and dose-limiting toxicity remain as major dilemmas for immunotherapy. Stimuli-responsive nanoparticles (srNPs) combined with immunotherapy offer the possibility to amplify anti-tumor immune responses, where the weak acidity, high concentration of glutathione, overexpressions of enzymes, and reactive oxygen species, and external stimuli in tumors act as triggers for controlled drug release. This review highlights the design of srNPs based on tumor microenvironment and/or external stimuli to combine with different anti-tumor drugs, especially the immunoregulatory agents, which eventually realize synergistic immunotherapy of malignant primary or metastatic tumors and acquire a long-term immune memory to prevent tumor recurrence. The authors hope that this review can provide theoretical guidance for the construction and clinical transformation of smart srNPs for controlled drug delivery in synergistic cancer immunotherapy.

show abstract

“…Hua et al designed a multistage-responsive Au clustered nanosystem that can effectively increase the accumulation of nanomaterials into tumor tissues, improve cellular uptake, and realize the combined therapy of photothermal RT. 93 Once the 50 nm CS-AU-ICG NPs accumulated in the acidic tumor region, large aggregates of approximately 1000 nm were assembled to improve retention in the tumor region. In addition, local NIR irradiation was applied to the tumor region to disrupt the aggregates into Au nanoclusters as small as 5 nm, thus improving cellular uptake and enhancing the radiosensitizing effect of Cs-Au-ICG NPs.…”

Section: Thermo-radiotherapymentioning

confidence: 99%

“…In addition, 131 I-bovine serum albumin (BSA)-liposome nanoparticles have recently been reported for use in immuno-radiotherapy. 93 The researchers selected PEG-modified nanoliposomes encapsulated with BSA as the carrier. 131 I penetrates its lipid bilayer and reacts with BSA to form nanoparticles.…”

Section: Immuno-radiotherapymentioning

confidence: 99%

Multifunctional high-Znanoradiosensitizers for multimodal synergistic cancer therapy

et al. 2022

View full text Add to dashboard Cite

show abstract

Multistage-responsive clustered nanosystem to improve tumor accumulation and penetration for photothermal/enhanced radiation synergistic therapy

Cited by 63 publications

References 48 publications

Biocompatible Nanomotors as Active Diagnostic Imaging Agents for Enhanced Magnetic Resonance Imaging of Tumor Tissues In Vivo

Biocompatible Nanomotors as Active Diagnostic Imaging Agents for Enhanced Magnetic Resonance Imaging of Tumor Tissues In Vivo

Stimuli‐Responsive Nanoparticles for Controlled Drug Delivery in Synergistic Cancer Immunotherapy

Multifunctional high-Znanoradiosensitizers for multimodal synergistic cancer therapy

Contact Info

Product

Resources

About