Multistate Outbreak of Multidrug-Resistant Salmonella Newport Infections Associated with Ground Beef, October to December 2007

Schneider, Jessica L.; White, Patricia L.; Weiss, Joli; Norton, Dawn M.; Lidgard, J.; Gould, L. Hannah; Yee, Bill; Vugia, Duc J.; Mohle-Boetani, Janet C.

doi:10.4315/0362-028x.jfp-11-046

Cited by 43 publications

(22 citation statements)

References 5 publications

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“…Serovars like Newport and Give are often found in animal feces [43,44], and have been linked to several outbreaks of salmonellosis in the recent past (e.g., serovars Give [45,46], Thompson [47][48][49] and Newport [50]). Pathogenicity tests with C. elegans as host resulted in survival curves (Fig.…”

Section: Resultsmentioning

confidence: 99%

Quantifying Salmonella Population Dynamics in Water and Biofilms

et al. 2012

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Members of the bacterial genus Salmonella are recognized worldwide as major zoonotic pathogens often found to persist in non-enteric environments including heterogeneous aquatic biofilms. In this study, Salmonella isolates that had been detected repeatedly over time in aquatic biofilms at different sites in Spring Lake, San Marcos, Texas, were identified as serovars Give, Thompson, Newport and -:z10:z39. Pathogenicity results from feeding studies with the nematode Caenorhabditis elegans as host confirmed that these strains were pathogenic, with Salmonella-fed C. elegans dying faster (mean survival time between 3 and 4 days) than controls, i.e., Escherichia coli-fed C. elegans (mean survival time of 9.5 days). Cells of these isolates inoculated into water at a density of up to 10(6) ml(-1) water declined numerically by 3 orders of magnitude within 2 days, reaching the detection limit of our quantitative polymerase chain reaction (qPCR)-based quantification technique (i.e., 10(3) cells ml(-1)). Similar patterns were obtained for cells in heterogeneous aquatic biofilms developed on tiles and originally free of Salmonella that were kept in the inoculated water. Cell numbers increased during the first days to more than 10(7) cells cm(-2), and then declined over time. Ten-fold higher cell numbers of Salmonella inoculated into water or into biofilm resulted in similar patterns of population dynamics, though cells in biofilms remained detectable with numbers around 10(4) cells cm(-2) after 4 weeks. Independent of detectability by qPCR, samples of all treatments harbored viable salmonellae that resembled the inoculated isolates after 4 weeks of incubation. These results demonstrate that pathogenic salmonellae were isolated from heterogeneous aquatic biofilms and that they could persist and stay viable in such biofilms in high numbers for some time.

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Section: Resultsmentioning

confidence: 99%

Quantifying Salmonella Population Dynamics in Water and Biofilms

et al. 2012

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“…A sporadic case–control study found associations between infection with multidrug-resistant strains of Salmonella serotype Newport and beef and egg consumption, whereas infection with pansusceptible strains was associated with direct or indirect exposure to frogs or lizards ( 23 ). In a similar manner, strains of serotype Newport causing several outbreaks attributed to beef or dairy products have been multidrug resistant ( 24 , 25 ), whereas outbreaks attributed to produce have generally been pansusceptible ( 26 , 27 ). Therefore, pansusceptibility might be a marker for serotype Newport strains with environmental reservoirs and a greater potential for transmission though produce.…”

Section: Discussionmentioning

confidence: 97%

Outbreak-associatedSalmonella entericaSerotypes and Food Commodities, United States, 1998–2008

Jackson¹,

Griffin²,

Cole³

et al. 2013

Emerg. Infect. Dis.

448

299

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Salmonella enterica infections are transmitted not only by animal-derived foods but also by vegetables, fruits, and other plant products. To clarify links between Salmonella serotypes and specific foods, we examined the diversity and predominance of food commodities implicated in outbreaks of salmonellosis during 1998–2008. More than 80% of outbreaks caused by serotypes Enteritidis, Heidelberg, and Hadar were attributed to eggs or poultry, whereas >50% of outbreaks caused by serotypes Javiana, Litchfield, Mbandaka, Muenchen, Poona, and Senftenberg were attributed to plant commodities. Serotypes Typhimurium and Newport were associated with a wide variety of food commodities. Knowledge about these associations can help guide outbreak investigations and control measures.

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“…Variations of antibiotic resistance genes incorporated on MGEs will also develop through point mutations (Muniesa et al, 2013). In addition to this model, antibiotic resistant foodborne pathogens can be transferred from livestock to humans through improperly cooked meat and cross-contamination (Centers for Disease Control and Prevention [CDC], 2002; Schneider et al, 2011). Irrigation water and manure application contaminate crops, which also leads to antibiotic resistant foodborne illnesses.…”

Section: Environmental Factors Associated With Bacteriophage Transducmentioning

confidence: 99%

Bacteriophages Contribute to the Spread of Antibiotic Resistance Genes among Foodborne Pathogens of the Enterobacteriaceae Family – A Review

et al. 2017

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Foodborne illnesses continue to have an economic impact on global health care systems. There is a growing concern regarding the increasing frequency of antibiotic resistance in foodborne bacterial pathogens and how such resistance may affect treatment outcomes. In an effort to better understand how to reduce the spread of resistance, many research studies have been conducted regarding the methods by which antibiotic resistance genes are mobilized and spread between bacteria. Transduction by bacteriophages (phages) is one of many horizontal gene transfer mechanisms, and recent findings have shown phage-mediated transduction to be a significant contributor to dissemination of antibiotic resistance genes. Here, we review the viability of transduction as a contributing factor to the dissemination of antibiotic resistance genes in foodborne pathogens of the Enterobacteriaceae family, including non-typhoidal Salmonella and Shiga toxin-producing Escherichia coli, as well as environmental factors that increase transduction of antibiotic resistance genes.

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Multistate Outbreak of Multidrug-Resistant Salmonella Newport Infections Associated with Ground Beef, October to December 2007

Cited by 43 publications

References 5 publications

Quantifying Salmonella Population Dynamics in Water and Biofilms

Quantifying Salmonella Population Dynamics in Water and Biofilms

Outbreak-associatedSalmonella entericaSerotypes and Food Commodities, United States, 1998–2008

Bacteriophages Contribute to the Spread of Antibiotic Resistance Genes among Foodborne Pathogens of the Enterobacteriaceae Family – A Review

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