Multitracer study on uptake and excretion of trace elements in rats

Yanaga, Makoto; Enomoto, Shuichi; Hirunuma, Rieko; Furuta, Riko; Endo, Kazutoyo; Tanaka, Akira; Ambe, S.; Tozawa, Machiko; Ambe, F.

doi:10.1016/0969-8043(95)00279-0

Cited by 19 publications

(6 citation statements)

References 8 publications

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“…This is straightforward for osmium and platinum atoms because their preceding chain members are also members of the platinum group, and all members of this group have the same model structure. Each compartment in the model for osmium and platinum is identified with the iridium compartment with the same name. (395) Rhenium is a member of Group VIIA of the periodic table and exhibits chemical and biokinetic properties remarkably close to those of the adjacent Group VIIA element technetium (Durbin et al., 1957; Deutsch et al., 1986; Yanaga et al., 1996, Dadachova et al., 2002; Zuckier et al., 2004). Rhenium and technetium presumably become covalently bound with oxide ions to form the structurally similar anions perrhenate (ReO 4 − ) and pertechnetate (TcO 4 − ) in the body and in many environment settings.…”

Section: Iridium (Z = 77)mentioning

confidence: 99%

ICRP Publication 137: Occupational Intakes of Radionuclides: Part 3

Paquet¹,

Bailey²,

Leggett³

et al. 2017

Ann ICRP

234

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The 2007 Recommendations of the International Commission on Radiological Protection (ICRP, 2007) introduced changes that affect the calculation of effective dose, and implied a revision of the dose coefficients for internal exposure, published previously in the Publication 30 series (ICRP, 1979, 1980, 1981, 1988) and Publication 68 (ICRP, 1994). In addition, new data are now available that support an update of the radionuclide-specific information given in Publications 54 and 78 (ICRP, 1988a, 1997b) for the design of monitoring programmes and retrospective assessment of occupational internal doses. Provision of new biokinetic models, dose coefficients, monitoring methods, and bioassay data was performed by Committee 2, Task Group 21 on Internal Dosimetry, and Task Group 4 on Dose Calculations. A new series, the Occupational Intakes of Radionuclides (OIR) series, will replace the Publication 30 series and Publications 54, 68, and 78. OIR Part 1 has been issued (ICRP, 2015), and describes the assessment of internal occupational exposure to radionuclides, biokinetic and dosimetric models, methods of individual and workplace monitoring, and general aspects of retrospective dose assessment. OIR Part 2 (ICRP, 2016), this current publication and upcoming publications in the OIR series (Parts 4 and 5) provide data on individual elements and their radioisotopes, including information on chemical forms encountered in the workplace; a list of principal radioisotopes and their physical half-lives and decay modes; the parameter values of the reference biokinetic model; and data on monitoring techniques for the radioisotopes encountered most commonly in workplaces. Reviews of data on inhalation, ingestion, and systemic biokinetics are also provided for most of the elements. Dosimetric data provided in the printed publications of the OIR series include tables of committed effective dose per intake (Sv Bq−1 intake) for inhalation and ingestion, tables of committed effective dose per content (Sv Bq−1 measurement) for inhalation, and graphs of retention and excretion data per Bq intake for inhalation. These data are provided for all absorption types and for the most common isotope(s) of each element. The electronic annex that accompanies the OIR series of publications contains a comprehensive set of committed effective and equivalent dose coefficients, committed effective dose per content functions, and reference bioassay functions. Data are provided for inhalation, ingestion, and direct input to blood. This third publication in the series provides the above data for the following elements: ruthenium (Ru), antimony (Sb), tellurium (Te), iodine (I), caesium (Cs), barium (Ba), iridium (Ir), lead (Pb), bismuth (Bi), polonium (Po), radon (Rn), radium (Ra), thorium (Th), and uranium (U).

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Section: Iridium (Z = 77)mentioning

confidence: 99%

ICRP Publication 137: Occupational Intakes of Radionuclides: Part 3

Paquet¹,

Bailey²,

Leggett³

et al. 2017

Ann ICRP

234

View full text Add to dashboard Cite

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“…An assessment of the environmental impact of these trace elements requires baseline data. However, few efforts have been made to characterize the accumulation of trace elements in wildlife in the marine environment except for some elements such as Hg, Cd, Zn, and Cu, whereas toxicological studies of other trace elements have gradually increased in recent years [3–6]. Data on the influence of gender, growth, and diet on the accumulation of trace elements in marine animals and their transfer through food chain also are scarce.…”

Section: Introductionmentioning

confidence: 99%

Trace element accumulation in hawksbill turtles (Eretmochelys imbricata) and green turtles (Chelonia mydas) from Yaeyama Islands, Japan

Anan

Kunito

Watanabe

et al. 2001

Enviro Toxic and Chemistry

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Concentrations of 18 trace elements (V, Cr, Mn, Co, Cu, Zn, Se, Rb, Sr, Zr, Mo, Ag, Cd, Sb, Ba, Hg, Tl, and Pb) were determined in the liver, kidney, and muscle of green turtles (Chelonia mydas) and hawksbill turtles (Eretmochelys imbricata) from Yaeyama Islands, Okinawa, Japan. Accumulation features of trace elements in the three tissues were similar between green and hawksbill turtles. No gender differences in trace element accumulation in liver and kidney were found for most of the elements. Significant growth-dependent variations were found in concentrations of some elements in tissues of green and hawksbill turtles. Significant negative correlations (p < 0.05) were found between standard carapace length (SCL) and the concentrations of Cu, Zn, and Se in the kidney and V in muscle of green turtles and Mn in the liver, Rb and Ag in kidney, and Hg in muscle of hawksbill turtles. Concentrations of Sr, Mo, Ag, Sb, and Tl in the liver, Sb in kidney, and Sb and Ba in muscle of green turtles and Se and Hg in the liver and Co, Se, and Hg in kidney of hawksbill turtles increased with an increase in SCL (p < 0.05). Green and hawksbill turtles accumulated extremely high concentrations of Cu in the liver and Cd in kidney, whereas the levels of Hg in liver were low in comparison with those of other higher-trophic-level marine animals. High accumulation of Ag in the liver of green turtles was also observed. To evaluate the trophic transfer of trace elements, concentrations of trace elements were determined in stomach contents of green and hawksbill turtles. A remarkably high trophic transfer coefficient was found for Ag and Cd in green turtles and for Cd and Hg in hawksbill turtles.

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“…6,7) The wide variety of applications can be attributed to the high resolution of detectors for g-ray energies, and allows for the simultaneous use of many tracers under identical conditions. We have applied this technique to study 1) the uptake of trace elements in rat organs, [8][9][10] 2) the affinity of metal ions to blood components, 11,12) and 3) the affinity of metal ions to sub-cellular components. [13][14][15] The multitracer technique itself has some limitations at the present time because of its low quantitative nature among the produced radioactive isotopes and the presence of long lived radioisotopes.…”

mentioning

confidence: 99%

In Vivo Multitracer Analysis Technique: Screening of Radioactive Probes for Noninvasive Measurement of Physiological Functions in Experimental Animals

Matsumoto

Hirunuma

Enomoto

et al. 2005

Biological & Pharmaceutical Bulletin

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A novel screening experiment, to find radioactive probes for non-invasive measurements of physiological functions in experimental animals, was tested using the in vivo multitracer analysis technique. The details of the efficiency of the detector settings used in the in vivo multitracer analysis technique were examined by both computer simulations and practical measurements. Multiple radioactive isotopes, i.e. multitracer, were prepared by irradiating a silver foil target with a heavy ion beam at the RIKEN ring cyclotron. After chemical separation of the silver target, the multitracer was finally dissolved in isotonic citrate buffer. The multitracer solution was intravenously injected into rats. Using a gamma-ray detector equipped with a well-defined slit, the collimated gamma-rays from the upper abdomen of living rats were measured. After correction of detection efficiencies, it was possible to compare the distribution of radioactive elements between two groups of rats different in body weight. The in vivo measurement showed that the tissue substantial volume of the selenium-deficient (SeD) rat liver increased compared to normal rats. The possibility of a functional estimation of tissue/blood volume for living rats was proposed based on the characteristic in vivo distribution of 74As, 83Rb and 103Ru.

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Multitracer study on uptake and excretion of trace elements in rats

Cited by 19 publications

References 8 publications

ICRP Publication 137: Occupational Intakes of Radionuclides: Part 3

ICRP Publication 137: Occupational Intakes of Radionuclides: Part 3

Trace element accumulation in hawksbill turtles (Eretmochelys imbricata) and green turtles (Chelonia mydas) from Yaeyama Islands, Japan

In Vivo Multitracer Analysis Technique: Screening of Radioactive Probes for Noninvasive Measurement of Physiological Functions in Experimental Animals

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