Multivalency in Supramolecular Chemistry and Nanofabrication

Abstract

For Abstract see ChemInform Abstract in Full Text.

Polyvalency: A promising strategy for drug design

“…In recent years, there has also been a tremendous interest in the design of novel polyvalent molecules (Badjic et al, 2005;Kane, 2006;Kiessling et al, 2006;Krishnamurthy et al, 2006;Mammen et al, 1998;Mulder et al, 2004).…”

Investigation of monovalent and bivalent enantioselective molecular recognition by electrospray ionization-mass spectrometry and tandem mass spectrometry

“…The latter points, (3) and (4) above, are consistent with expected results for a well behaved multiple monovalent interaction system. The discrepancies described in the former points, (1) and (2), are most likely due to systematic errors that can be ascribed to the relative response factor variation. In other words, the measurements for the multiple monovalent system are of interest to show the equivalence of binding sites, but the magnitude of the dissociation constants are probably not comparable to that for the monovalent and bivalent systems.…”

“…Related work has included collaborative efforts to incorporate multivalency into the design of nanomachines such as molecular elevators [13]. Reinhoudt and coworkers have also made substantial contributions to the use and understanding of multivalency in nanofabrication processes [2,3,14].…”

Unconventional Approaches Involving Cyclodextrin-Based, Self-Assembly-Driven Processes for the Conversion of Organic Substrates in Aqueous Biphasic Catalysis

“…Multivalency is a powerful self-assembly pathway that confers unique molecular recognition between polytopic hosts and guests [33,34]. Large hosts with extended cavities are then highly desirable to fully accommodate hydrophobic substrates through multivalency.…”