Multivariate calibration techniques applied to the spectrophotometric analysis of one-to-four component systems

Simultaneous Determination of Albendazole and Praziquantel by Second Derivative Spectrophotometry and Multivariated Calibration Methods in Veterinary Pharmaceutical Formulation

“…All the multivariate models utilized cross validation, removing in turn each standard from the training set and then predicting the excluded sample with the calibration, similar to procedures utilized in the literature. 41 The optimal baseline order for CLS was determined by minimizing the model error sum of squares (ESS).…”

“…The prediction residual error sum of squares (PRESS), standard error of cross-validation (SECV) as well as the correlation coefficient (rVal) for the predicted Y values versus known Y values were calculated, considering the cross validation. 40 In the PCR and PLS calibration methods, these parameters were calculated according to Ragno et al 41 and Afkhami et al…”

Simultaneous Spectrophotometric Estimation of Bisoprolol Fumarate and Hydrochlorothiazide in Tablet Formulation using Partial Least-Squares, Principal Component Regression Multivariate Calibrations and RP-HPLC Methods

“…Such methods have been reported to be a valid alternative to HPLC for the analysis of different analytes in pharmaceutical preparations [27]. PCR and PLS are multivariate regression methods which allow to establish a relationship between matrices of chemical data [28] The basic concept of PLS regression was originally developed by Wold [29]. Readers interested in more mathematical principles of the PLS algorithms are encouraged to refer to the book by Vinzi et al [30].…”

Simultaneous Determination of Metamizole, Thiamin and Pyridoxin Using UV-Spectroscopy in Combination with Multivariate Calibration

“…Although low selectivity and sensitivity, the spectrophotometric techniques is the most interesting approach to be applied in pharmaceutical analysis owing to its simplicity. However, in many cases of the multicomponents assay in pharmaceutical preparation, UV-VIS spectrophotometric techniques showed useless results because of a high number of components and the extensive spectral overlapping, 17 therefore, the chemometrics technique is applied to resolve this problem. 18 Currently, the application of chemometric techniques, especially multivariate calibrations are playing a very important role in the multicomponent analysis of pharmaceutical mixtures.…”