In this paper, a model of mumps transmission with quarantine measure is proposed and then the control reproduction number Rc of the model is obtained. This model admits a unique endemic equilibrium P * if and only if Rc > 1, while the disease-free equilibrium P 0 always exists. By using the technique of constructing Lyapunov functions and the generalized Lyapunov-LaSalle theorem, we first show that the equilibrium P 0 is globally asymptotically stable (GAS) if Rc ≤ 1; second, we prove that the equilibrium P * is GAS if Rc > 1.Our results reveal that mumps can be eliminated from the community for Rc ≤ 1 and it will be persistent for Rc > 1, and quarantine measure can also effectively control the mumps transmission.