1968
DOI: 10.1016/0024-3205(68)90325-1
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Muricidal block produced by 5-hydroxytryptophan and various drugs

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Cited by 79 publications
(12 citation statements)
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“…Nevertheless, 50% of the depressants or of 5-hydroxytryptophan (Horovitz, Ragozzino, & Leaf, 1965;Karli, 1959b;Kulkarni, 1968). The supposition has been made that the amygdaloid nuclei playa role in this inhibitory effect of monoamines upon mouse killing (Horovitz, Piala, High, Burke, & Leaf, 1966;Leaf, Lerner, & Horovitz, 1969).…”
Section: Resultsmentioning
confidence: 99%
“…Nevertheless, 50% of the depressants or of 5-hydroxytryptophan (Horovitz, Ragozzino, & Leaf, 1965;Karli, 1959b;Kulkarni, 1968). The supposition has been made that the amygdaloid nuclei playa role in this inhibitory effect of monoamines upon mouse killing (Horovitz, Piala, High, Burke, & Leaf, 1966;Leaf, Lerner, & Horovitz, 1969).…”
Section: Resultsmentioning
confidence: 99%
“…Pharma cological manipulations of the central serotonergic system have been shown to modify aggression in numerous stud ies: reducing 5-HT levels by either /^chlorophenylalanine [3], dihydroxytryptamine [4] or low-tryptophan diet [5] elevated aggression while the application of 5-HT [6] or enhancing its synthesis by 5-hydroxytryptophan [7] sup pressed aggression in animals. Similarly, increasing 5-HT activity in human subjects by either 5-hydroxytryptophan [8] or high-tryptophan diet [9] inhibited aggressive behav ior.…”
Section: Introductionmentioning
confidence: 99%
“…Similarly, lesions of the serotonin-containing cell bodies in the raphe system increase home-cage aggression (Sheard, 1973) and muricide behaviour (Grant et al, 1973;Vergnes, Mack et al, 1974b;Vergnes, Boehrer et al, 1974a) in rats. Conversely, increased serotonergic activity by injection of the 5-HT precursor, dl-SHTP, inhibits isolated-induced fighting in mice (Hodge and Butcher, 1974) and rat muricidal behaviour (DiChiara et al, 1971;Kulkarni, 1968 andMiczek et al, 1975;Vergnes, Mack et al, 1974b).…”
Section: Introductionmentioning
confidence: 99%