2010
DOI: 10.1007/s00428-010-0974-9
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Murine immune response induced by Leishmania major during the implantation of paraffin tablets

Abstract: We carried out a model of chronic inflammation using a subcutaneous paraffin tablet in mice experimentally infected with Leishmania major. It was previously reported that the parasite load following paraffin implantation occurred at a peak of 21 days in both BALB/c and C57BL/6 mice. At the present study, we have investigated what cytokines and chemokines are directly related to the parasite load in C57BL/6 mice. All mice were divided in four groups: mice implanted with paraffin tablets; mice experimentally inf… Show more

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Cited by 3 publications
(1 citation statement)
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“…Increased levels of certain parameters such as parasite load, IL-10, TGF-β, or Leishmania -specific IgG, IgM, IgA, and IgE serum antibodies are indicators of disease progression. By contrast, increased levels of peripheral blood mononuclear cells (PBMC) proliferation after leishmanial antigen stimulation, interferon gamma (IFN-γ) and tumor necrosis factor alpha (TNF-α) expression, proliferation of CD4+, CD8+, and B-cell subsets, or a positive Leishmania skin test (LST) are associated with resistance [ 12 ]. Accordingly, increased levels of IFN-γ in cured cases have been reported [ 13 ].…”
Section: Introductionmentioning
confidence: 99%
“…Increased levels of certain parameters such as parasite load, IL-10, TGF-β, or Leishmania -specific IgG, IgM, IgA, and IgE serum antibodies are indicators of disease progression. By contrast, increased levels of peripheral blood mononuclear cells (PBMC) proliferation after leishmanial antigen stimulation, interferon gamma (IFN-γ) and tumor necrosis factor alpha (TNF-α) expression, proliferation of CD4+, CD8+, and B-cell subsets, or a positive Leishmania skin test (LST) are associated with resistance [ 12 ]. Accordingly, increased levels of IFN-γ in cured cases have been reported [ 13 ].…”
Section: Introductionmentioning
confidence: 99%