Muscarine, imidazole, oxazole, thiazole, Amaryllidaceae and Sceletium alkaloids

Abstract

A review with 136 references covers the literature from July 2000 to June 2001 on the isolation, bioactivities, and synthetic highlights of complex natural products including muscarine, imidazole, oxazole, thiazole, Amaryllidaceae and Sceletium alkaloids.

Chapter 3 Chemical and Biological Aspects of Narcissus Alkaloids

“…The history of the Amaryllidaceae alkaloids, their structural elucidation, and their biological profiles, as well as their synthesis, have been summarized on several occasions (20,33,(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48) which, together with the regular publications in the journal Natural Product Reports (34,(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59)(60)(61)(62)(63)(64)(65)(66), represent a valuable source of information.…”

“…An exhaustive report is beyond the scope of this chapter, and the reader is referred to recent and excellent reviews in the field for a more thorough account (34,(60)(61)(62)(63)(64)(65)(66)210,211). An exhaustive report is beyond the scope of this chapter, and the reader is referred to recent and excellent reviews in the field for a more thorough account (34,(60)(61)(62)(63)(64)(65)(66)210,211).…”

Marine natural products

“…7 A personal perspective on research programs which have been inspired by palytoxin has been given by Kishi. Marine-derived compounds are included in "Natural guanidine derivatives", 15 "Muscarine, imidazole, oxazole, thiazole, Amaryllidaceae and Sceletium alkaloids", 16 "Natural halogenated fatty acids: their analogues and derivatives", 17 "Simple indole alkaloids and those with a nonrearranged monoterpenoid unit", 18 "Indolizidine and quinolizidine alkaloids", 19 "Bromo-and iodo-containing alkaloids from marine microorganisms and sponges", 20 "Natural occurrence of boron-containing compounds in plants, algae and microorganisms", 21 "Sterols in marine invertebrates", 22 and "Structural diversity of marine oxylipins". 9 Ecteinascidins feature in two reviews, "Ecteinascidin 743: a novel anticancer drug with a unique mechanism of action" 10 and "Chemistry and biology of the tetrahydroisoquinoline antitumour antibiotics".…”

Design and synthesis of optically active 2‐phenylimidazolecarboxamides featuring amino acid motive

“…Dimethyl 2-Phenyl-1H-imidazole-4,5-dicarboxylate (9). The title compound was synthesized following the same procedure as described for 5 refluxing the reaction mixture for General Procedure for Method A.…”