Muschel‐inspirierte dendritische Polymere als universelle multifunktionale Beschichtungen

Wei, Qiang; Achazi, Katharina; Liebe, Hendrik; Schulz, Andrea; Noeske, Michael; Grunwald, Ingo; Haag, Rainer

doi:10.1002/ange.201407113

Cited by 31 publications

(6 citation statements)

References 42 publications

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“…It is known that multivalently presented catechol groups alone do not exhibit a robust surface anchoring capability, and the presence of amine groups is important . The ratio of unreacted amine groups remaining on the polymer system to catechol groups (≈2:1) is similar to other reports for stable coatings . Some of the free amine groups can be also further conjugated to introduce new properties to the substrate, e.g., conjugation of AMPs to introduce bactericidal activity as will be seen here subsequently.…”

Section: Resultssupporting

confidence: 79%

“…Some examples are a catechol (dopamine moiety) and zwitterion‐bifunctionalized PEG coating for stainless steel, titanium and silicon wafers, poly(sulfobetaine methacrylate)–catechol conjugates for poly( l ‐lactic) acid films, and poly(ethoxyethyl glycidyl ether) with both vinyl and catechol functional side groups for glass slides . Also, this concept was transferred to dendritic polyglycerols with the success of fast and universal adhesion on material surfaces …”

Section: Introductionmentioning

confidence: 99%

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Development of Antifouling and Bactericidal Coatings for Platelet Storage Bags Using Dopamine Chemistry

Hadjesfandiari

Weinhart

Kizhakkedathu

et al. 2017

Adv Healthcare Materials

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Platelets have a limited shelf life, due to the risk of bacterial contamination and platelet quality loss. Most platelet storage bags are made of a mixture of polyvinyl chloride with a plasticizer, denoted as pPVC. To improve biocompatibility of pPVC with platelets and to inhibit bacterial biofilm formation, an antifouling polymer coating is developed using mussel-inspired chemistry. A copolymer of N,N-dimethylacrylamide and N-(3-aminopropyl)methacrylamide hydrochloride is synthesized and coupled with catechol groups, named DA51-cat. Under mild aqueous conditions, pPVC is first equilibrated with an anchoring polydopamine layer, followed by a DA51-cat layer. Measurements show this coating decreases fibrinogen adsorption to 5% of the control surfaces. One-step coating with DA51-cat does not coat pPVC efficiently although it is sufficient for coating silicon wafers and gold substrates. The dual layer coating on platelet bags resists bacterial biofilm formation and considerably decreases platelet adhesion. A cationic antimicrobial peptide, E6, is conjugated to DA51-cat then coated on silicon wafers and introduces bactericidal activity to these surfaces. Time-of-flight second ion-mass spectroscopy is successfully applied to characterize these surfaces. pPVC is widely used in medical devices; this method provides an approach to controlling biofouling and bacterial growth on it without elaborate surface modification procedures.

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Section: Resultssupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Development of Antifouling and Bactericidal Coatings for Platelet Storage Bags Using Dopamine Chemistry

Hadjesfandiari

Weinhart

Kizhakkedathu

et al. 2017

Adv Healthcare Materials

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“…75 Dopamine molecules can also be introduced into functional polymers such as dendritic polymers or block copolymers to endow them with strong adhesive ability. [76][77][78] Mussel-Inspired Superwetting Materials for Oil/Water Separation Oil spills and petroleum-based pollution are an ongoing global challenge to the marine environment and ecosystem. Traditional membranes and adsorbents cannot meet the growing demand for effective oil/water separation.…”

Section: Adhesion: Interactions Between Pda and Substratesmentioning

confidence: 99%

Mussel-Inspired Surface Engineering for Water-Remediation Materials

Wang

Yang

et al. 2019

Matter

328

177

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Mussel-inspired chemistry, as a powerful tool to manipulate material properties, has been widely studied and implemented in surface engineering of a variety of materials for multipurpose functionalization. With the rapid development of this field, more flexible and efficient modification strategies for surface engineering and application modes have been developed recently. It is therefore critical to update the broader scientific community on the important advances in this interdisciplinary field. Here, we summarize recent progress in musselinspired chemistry and its emerging applications in water remediation. The reaction and adhesion mechanisms of polydopamine, as well as its chemical and physical properties, are discussed. The functionalization strategies are categorized into post-functionalization, co-deposition, and pre-modification, and the roles of mussel-inspired surface coatings are highlighted in filtration, adsorbing, and catalytic materials as well as the burgeoning area of photothermal distillation materials.

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“…20 In addition, catechol groups can be coordinately cross-linked by metal ions 21,22,40 such as Fe, Mn, Ti, Zn, and Ca 41 and covalently cross-linked under basic environment getting oxidized automatically. 15,23,24 However, only the moderate cross-linker Zn forms fluidic and coacervate-like complexes with PAADopa at low pH conditions. 25 This cross-linking structure makes the film become much more compact and significantly increases its mechanical strength.…”

Section: Introductionmentioning

confidence: 99%

Construction of Compact Polyelectrolyte Multilayers Inspired by Marine Mussel: Effects of Salt Concentration and pH As Observed by QCM-D and AFM

Wang

Backes

et al. 2016

Langmuir

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Biomimetic multilayers based on layer-by-layer (LbL) assembly were prepared as functional films with compact structure by incorporating the mussel-inspired catechol cross-linking. Dopamine-modified poly(acrylic acid) (PAADopa) was synthesized as a polyanion to offer electrostatic interaction with the prelayer polyethylenimine (PEI) and consecutively cross-linked by zinc to generate compact multilayers with tunable physicochemical properties. In situ layer-by-layer growth and cross-linking were monitored by a quartz crystal microbalance with dissipation (QCM-D) to reveal the kinetics of the process and the influence of Dopa chemistry. Addition of Dopa enhanced the mass adsorption and led to the formation of a more compact structure. An increase of ionic strength induced an increase in mass adsorption in the Dopa-cross-linked multilayers. This is a universal approach for coating of various surfaces such as Au, SiO2, Ti, and Al2O3. Roughness observed by AFM in both wet and dry conditions was compared to confirm the compact morphology of Dopa-cross-linked multilayers. Because of the pH sensitivity of Dopa moiety, metal-chelated Dopa groups can be turned into softer structure at higher pH as revealed by reduction of Young's modulus determined by MFP-3D AFM. A deeper insight into the growth and mechanical properties of Dopa-cross-linked polyelectrolyte multilayers was addressed in the present study. This allows a better control of these systems for bioapplications.

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Muschel‐inspirierte dendritische Polymere als universelle multifunktionale Beschichtungen

Cited by 31 publications

References 42 publications

Development of Antifouling and Bactericidal Coatings for Platelet Storage Bags Using Dopamine Chemistry

Development of Antifouling and Bactericidal Coatings for Platelet Storage Bags Using Dopamine Chemistry

Mussel-Inspired Surface Engineering for Water-Remediation Materials

Construction of Compact Polyelectrolyte Multilayers Inspired by Marine Mussel: Effects of Salt Concentration and pH As Observed by QCM-D and AFM

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